The Contribution of Nitric Oxide and Endothelium-Derived Hyperpolarizing Factor to Resting and Stimulated Vasodilator Tone in African American and Whites

Ozkor, Muhiddin; Murrow, Jonathan R.; Rahman, Ayaz; Kavtaradze, Nino; Arshad, Shawn; Syed, Hamid; Lin, Ji; Manatunga, Amita K.; Quyyumi, Arshed A

doi:10.1016/s0735-1097(10)61597-5

Cited by 1 publication

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“…In previous studies in hypertensive patients of both ethnicities, we and others found that acetylcholine‐mediated NO release was lower compared with that in normotensive controls . In fact, L‐NMMA did not inhibit acetylcholine responses in untreated hypertensive patients.…”

Section: Discussioncontrasting

confidence: 48%

“…Using these antagonists, we and others have shown that EDHF contributes to resting vasodilator tone and to bradykinin‐mediated vasodilation in healthy patients . Furthermore, we found that NO but not EDHF activity is reduced in the forearm vasculature of AAs compared with whites …”

supporting

confidence: 51%

“…Compared with whites, both healthy and hypertensive AAs have diminished basal NO activity and reduced endothelium‐dependent and ‐independent vasodilation . In this study, we found evidence for NO bioavailability at rest during treatment with both nebivolol and metoprolol succinate in hypertensive AA patients, with a clear trend for a greater contribution of NO during nebivolol therapy.…”

Section: Discussionmentioning

confidence: 49%

“…Exercise‐induced vasodilation is a complex process involving multiple vasodilator mechanisms including a modest contribution of NO and various putative EDHFs . We previously demonstrated that both NO and EDHF contribute individually to and in concert with exercise‐induced microvascular vasodilation in healthy human forearm circulation.…”

Section: Discussionmentioning

confidence: 99%

“…African Americans (AAs) have a higher burden of hypertension and its associated target organ damage, including nephropathy, stroke, myocardial infarction, and cardiovascular mortality . In comparison to their white counterparts, AAs have decreased NO bioavailability and worse endothelial function that has been attributed to both decreased production and increased degradation of NO …”

mentioning

confidence: 99%

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Nitric Oxide Contributes to Vasomotor Tone in Hypertensive African Americans Treated With Nebivolol and Metoprolol

Neuman

Hayek

Poole

et al. 2015

J of Clinical Hypertension

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Endothelial dysfunction is more prevalent in African Americans (AA) compared to whites. We hypothesized that nebivolol, a selective β-1 antagonist that stimulates NO, will improve endothelial function in AA with hypertension when compared to metoprolol. In a double-blind, randomized, cross-over study, 19 AA hypertensive subjects were randomized to a 12-week treatment period with either nebivolol 10mg or metoprolol succinate 100mg daily. Forearm blood flow (FBF) was measured using plethysmography at rest and after intra-arterial infusion of acetylcholine, and sodium nitroprusside to estimate endothelium-dependent and independent vasodilation, respectively. Physiologic vasodilation was assessed during hand-grip exercise. Measurements were repeated after NO blockade with L-NG-monomethylarginine (L-NMMA), and after inhibition of endothelium-derived hyperpolarizing factor (EDHF) with tetraethylammonium chloride (TEA). NO blockade with L-NMMA produced a trend toward greater vasoconstriction during nebivolol compared to metoprolol treatment period (21% vs 12% reduction in FBF, p=0.06, respectively). This difference was more significant after combined administration of L-NMMA and TEA (p<0.001). Similarly, there was a contribution of NO to exercise-induced vasodilation during nebivolol but not during metoprolol treatment. There were significantly greater contributions of NO and EDHF to resting vasodilator tone and of NO to exercise-induced vasodilation with nebivolol compared to metoprolol in AA with hypertension.

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Section: Discussioncontrasting

confidence: 48%

supporting

confidence: 51%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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