The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives

Taofiq, Oludemi; Calhelha, Ricardo C.; Heleno, Sandrina A.; Barros, Lillian; Martins, Anabela; Santos‐Buelga, Celestino; Queiroz, Maria João R. P.; Ferreira, Isabel C.F.R.

doi:10.1016/j.foodres.2015.07.044

Cited by 133 publications

(101 citation statements)

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“…This assay is one of the most common and widely used for evaluation of anti-inflammatory activity as reported by different authors (Moro et al, 2012;Taofiq et al, 2015).…”

Section: Nsaids and Their Mechanism Of Actionmentioning

confidence: 99%

“…Numerous investigations have suggested that several mushroom species can exhibit antiinflammatory potential based on their ability to reduce the production of inflammatory mediators (Kim et al, 2003;Padilha et al, 2009;Wen et al, 2011;Elsayed, Hesham, Mohammad, & Aziz, 2014Taofiq et al, 2015. Their crude extracts (Table 1) have been described to display activity, and attention is now being focused on efforts to discover bioactive compounds capable to suppress the production of inflammatory mediators through gene expression downregulation of different types of inflammatory mediators (Kim et al, 2006, Fangkrathok, Junlatat, & Sripanidkulchai, 2013.…”

Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

“…An immune stimulant causes the pro-inflammatory cells, such as macrophages and monocytes, to start to secrete a number of inflammatory mediators such as interleukins (IL 1β,, tumor necrosis factor (TNF-α), nuclear factor-κB (NF-κB), intercellular adhesion molecule-1 (ICAM-1), inducible type cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), 5-lipoxygenase (5-LOX), and inducible nitric oxide synthase (iNOS) (Moro et al, 2012;Choi et al, 2014a;Taofiq et al, 2015). Uncontrolled production of these inflammatory mediators has been known to cause several cell damage and also initiate the inflammation process (Kanwar, Kanwar, Burrow, & Baratchi, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have been conducted to evidence the bioactive properties of mushroom extracts as well as of their secondary metabolites such as antioxidant (Ferreira, Barros, & Abreu, 2009;Heleno, Martins, Queiroz, & Ferreira, 2015;Puttaraju, Venkateshaiah, Dharmesh, Urs, &Somasundaram, 2006), antitumor (Carocho & Ferreira, 2013;Ferreira, Vaz, Vasconcelos, & Martins, 2010;Moradali, Mostafavi, Ghods, & Hedjaroude, 2007),…”

Section: Introductionmentioning

confidence: 99%

“…antimicrobial (Alves et al, 2012(Alves et al, , 2013a, immunomodulator (Borchers, Krishnamurthy, Keen, Meyers, & Gershwin, 2008), antiatherogenic (Mori, Kobayashi, Tomita, Inatomi, & Ikeda, 2008) hypoglycemic (Hu, Wang, Lien, Liaw, & Lee, 2006) and anti-inflammatory (Moro et al, 2012;Tung et al, 2013;Xu et al, 2013;Choi et al, 2014a;Taofiq et al, 2015) activities.…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

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108

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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“…This assay is one of the most common and widely used for evaluation of anti-inflammatory activity as reported by different authors (Moro et al, 2012;Taofiq et al, 2015).…”

Section: Nsaids and Their Mechanism Of Actionmentioning

confidence: 99%