The contribution of reactive oxygen species to sarcopenia and muscle ageing

Fulle, Stefania; Protasi, Feliciano; Tano, Guglielmo Di; Pietrangelo, Tiziana; Beltramin, Andrea; Boncompagni, Simona; Vecchiet, L; Fanò, Giorgio

doi:10.1016/j.exger.2003.09.012

Cited by 367 publications

(270 citation statements)

References 66 publications

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“…Previously, we reported ROS damage in both mature muscle (Fulle et al, 2004) fibers and muscle resident satellite cells in which some functional parameters are modified (Fulle et al, 2005). In fact, our data revealed an age-dependent increase in lipid peroxidation in cultured myotubes.…”

Section: Introductionsupporting

confidence: 49%

“…Sarcopenia is defined as the age-related loss of muscle mass, strength and function (Vandervoort et al, 2001;Waters et al, 2000) associated with a decline in cell functional capability (Fulle et al, 2004) . This process appears to begin in the fourth decade of life, and accelerates after approximately 75 years of age (Waters et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

“…Cells are exposed to oxidative stress as a result of one or more of three factors: i) increase in oxidant generation, ii) decrease in antioxidant protection, and iii) failure to repair oxidative damage. ROS cause damage to lipids, nucleic acids and proteins (Berlett and Stadtman, 1997;Mecocci et al, 1999), and lead to a functional deficit in the control of Ca 2+ homeostasis in myofibers as a consequence (Eu et al, 2000;Fulle et al, 2004;Fulle et al 2005;Squier and Bigelow, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Pietrangelo¹,

Puglielli²,

Mancinelli³

et al. 2009

Experimental Gerontology

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ular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation. Experimental Gerontology, Elsevier, 2009, 44 (8) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 2 ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT AbstractSarcopenia is the age-related loss of muscle mass, strength and function. Human muscle proteins are synthesized at a slower rate in the elderly than in young adults, leading to atrophy and muscle mass loss with a decline in the functional capability. Additionally, aging is accompanied by a decrease in the ability of muscle tissue to regenerate following injury or overuse due to the impairment of intervening satellite cells, in which we previously reported oxidative damage evidences. The aim of the present study was to determine the effects of aging on myoblasts and myotubes obtained from human skeletal muscle, and characterize the transcriptional profile as molecular expression patterns in relation to age-dependent modifications in their regenerative capacity. Our data show that the failure to differentiate does not depend on reduced myogenic cell number, but difficulty to complete the differentiation program. Data reported here suggested the following findings: i) oxidative damage accumulation in molecular substrates, probably due to impaired antioxidant activity and insufficient repair capability, ii) limited capability of elderly myoblasts to execute a complete differentiation program; restricted fusion, possibly due to altered cytoskeleton turnover and extracellular matrix degradation, and iii) activation of atrophy mechanism by activation of a specific FOXO-dependent program.

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Section: Introductionsupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Pietrangelo¹,

Puglielli²,

Mancinelli³

et al. 2009

Experimental Gerontology

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“…Although the mechanisms are not fully understood, aging may increase connective tissue via higher cytokine levels, oxidative stress, and increased mechanical stress between fibers as they atrophy (Ahmed et al, 2005;Fulle et al, 2004;Kjaer, 2003;Song et al, 2006). Recently, our laboratory found that 3 months of treadmill exercise retarded age-induced fiber atrophy in the tibialis anterior muscle .…”

Section: Discussionmentioning

confidence: 99%

Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat

Kim

Kwak

Leeuwenburgh

et al. 2008

Experimental Gerontology

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Muscle atrophy is a highly prevalent condition among older adults, and results from reduced muscle mass and fiber cross-sectional area. Resistive exercise training and moderate (30-40%) caloric restriction may reduce the rate of sarcopenia in animal models. We tested the hypothesis that lifelong, voluntary exercise combined with mild (8%) caloric restriction would attenuate the reduction of muscle fiber cross-sectional area in the rat plantaris. Fischer-344 rats were divided into: young adults (6 mo.) fed ad libitum (YAL); 24 mo. old fed ad libitum (OAL); 24 mo. old on 8% caloric restriction (OCR); lifelong wheel running with 8% CR (OExCR). Plantaris fiber cross-sectional area was significantly lower in OAL than YAL (−27%), but protected in OCR and OExCR, while mass/body mass ratio was preserved in OExCR only. Furthermore, 8% CR and lifelong wheel running attenuated the age-induced increases in extramyocyte space and connective tissue. Citrate synthase activity decreased with age, but was not significantly protected in OCR and OExCR. Total hydroperoxides were higher in OAL than YAL, but were not elevated in OExCR, with no change in MnSOD. IGF-1 levels were lower in OAL (−57%) than YAL, but partially protected in the OExCR group (+51%).

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“…Of the known selenoproteins, there are three known serum selenium containing proteins: extracellular glutathione peroxidase, selenoprotein P and albumin [21]. Selenium plays an essential role in muscle function [27] and selenoenzymes such as glutathione peroxidase protect myocytes from reactive oxygen species [8]. Selenoprotein W has been shown to contain reduced glutathione, therefore it may also be involved with antioxidant functions [1].…”

Section: Introductionmentioning

confidence: 99%

Low serum selenium concentrations are associated with poor grip strength among older women living in the community

et al. 2007

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Aging is associated with a loss of muscle strength, and, in turn, loss of muscle strength has been associated with increased risk of frailty, disability and mortality. The factors that contribute to loss of muscle strength with aging have not been well characterized. Selenium is important in normal muscle function because of its role in selenoenzymes that protect muscle against oxidative damage. We hypothesized that low serum selenium concentrations were associated with poor grip strength. We examined the association between serum selenium and hand grip strength among 676 moderately to severely disabled community-dwelling women in the Women's Health and Aging Study I in Baltimore, Maryland. After adjusting for age, race, body mass index, Mini-Mental Status Examination score, current smoking, hypertension, congestive heart failure and depression, serum selenium was associated with grip strength (P = 0.04). This study supports the idea that selenium is important to muscle strength in older women.

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The contribution of reactive oxygen species to sarcopenia and muscle ageing

Cited by 367 publications

References 66 publications

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Molecular basis of the myogenic profile of aged human skeletal muscle satellite cells during differentiation

Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat

Low serum selenium concentrations are associated with poor grip strength among older women living in the community

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