The control of beads diameter of bead-on-string electrospun nanofibers and the corresponding release behaviors of embedded drugs

Li, Tingxiao; Ding, Xin; Tian, Lingling; Hu, Jiyong; Yang, Xudong; Ramakrishna, Seeram

doi:10.1016/j.msec.2016.12.050

Cited by 65 publications

(49 citation statements)

References 26 publications

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“…In the context of beaded SF mesh, the electrospun layer on the surface of SF mesh was formed by a large collection of randomly oriented bead‐on‐string fibers without CPT, which had a diameter below 300 nm. Furthermore, the morphology of beads along the electrospun PLGA fibers was spherical, whereas it changed to fusiform with the introduction of CPT, which was in agreement with reported study . These results suggest that the addition of CPT into the spinning solution plays an important role in the formation of beads along the electrospun fibers, which might be ascribed to the variation of viscosity of electrospinning solution in the presence and absence of CPT.…”

Section: Resultssupporting

confidence: 91%

“…Recent report revealed that they were effective to load drugs and showed encouraging benefits in sustained drug release . Nevertheless, beaded structure along the fibers caused a significantly decrease in mechanical properties of fibers . Textile technology is commonly used in textile industry, and can produce 3D meshes with excellent mechanical properties .…”

Section: Introductionmentioning

confidence: 99%

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Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer

Gou

Wang

et al. 2018

Macro Materials & Eng

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Bead‐on‐string electrospun fibers containing camptothecin (CPT) are fabricated on the surface of knitted silk fibroin (SF) meshes. Microscopic characterization reveals that the bead‐on‐string structure is prepared successfully and CPT is mainly located within the beaded structure. Interestingly, the CPT‐loaded beaded SF mesh (CPT‐SF mesh) has excellent mechanical properties. More importantly, it is able to perform a sustained CPT release without burst release. In vitro cytotoxicity tests further indicate that the CPT‐SF mesh shows much stronger anticolon cancer activity in comparison with SF meshes and beaded SF meshes. Hence, the CPT‐SF mesh has great potential as a promising local drug delivery system for colon cancer treatment.

show abstract

Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer

Gou

Wang

et al. 2018

Macro Materials & Eng

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“…The presence of beads is frequently related to the poor mechanical properties of the fibers . Nevertheless, the beads on the fibers are found to be functional in drug release applications in human bodies . The drugs encapsulated in the beads of the fibers are found to have a sustained release which is favorable for cell differentiation in tissue engineering rather than a burst release.…”

Section: Introductionmentioning

confidence: 99%

Design of polyurethane fibers: Relation between the spinning technique and the resulting fiber topology

Joo

Lee

Ang

et al. 2019

J of Applied Polymer Sci

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Properties or characteristics of fibers are affected by their topology. In fact, these topologies are found to have significant impacts in the functionalities of many applications. Hence, in this study, the relations between the spinning techniques and the topology of the resulting fibers are studied with the aim to provide a guideline for future reference where fibers with certain topology can be fabricated to suit specific applications. For this purpose, polyurethane is chosen to be the raw material to fabricate the fibers due to its versatility to be applied in various fields. The surface morphology, structures, and alignments of the fibers are studied. It is found that the polymer solution properties largely influence the mechanisms in the spinning process and can significantly affect the topology of the fibers. For instance, viscous solutions enable the spinning of coiled and smooth fibers, whereas conductive solutions encourage the splaying of the solution jet which results in the spinning of straight fibers.

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“…[ 18b ] Moreover, microbeads with diameter of 3.8 ± 0.5 µm were evenly distributed within the fibrous network in the composite membrane, and the beaded nanofibers have been proven effective for drug encapsulation and sustainable release of bioactive agents (Figure 1E–G). [ 20 ] Thus we used high performance liquid chromatography (HPLC) to assess the release behavior of MLT from multilayered membrane (ML‐M) and single‐layer membrane (SL‐M) electrospun scaffolds. As shown in Figure 1H, almost 80% of MLT released from multilayered scaffold within 7 d, while release of MLT from single‐layer scaffold was only 54% even after 21 d. Following PNI, rapid oxidative stress and inflammatory response may result in worse recovery without effective suppression.…”

Section: Resultsmentioning

confidence: 99%

Electrospinning Multilayered Scaffolds Loaded with Melatonin and Fe₃O₄ Magnetic Nanoparticles for Peripheral Nerve Regeneration

Chen

Qian

et al. 2020

Adv Funct Materials

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Peripheral nerve injury is a common clinical problem bringing heavy burden to patients, due to its high incidence and unsatisfactory treatment. Nerve guidance conduit (NGC) is a promising scaffold for peripheral nerve repair, and bioactive agents are applied for great functional recovery. Melatonin (MLT) and Fe3O4 magnetic nanoparticles (Fe3O4‐MNPs) are proven to inhibit oxidative stress, inflammation, and induce nerve regeneration. Herein, a multilayered composite NGC loaded with MLT and Fe3O4‐MNPs is designed for sequential and sustainable drug release, creating an appropriate microenvironment for nerve regeneration. The composite scaffold shows sufficient mechanical strength and biocompatibility in vitro, and evidently promotes morphological, functional, and electrophysiological recovery of regenerated sciatic nerves in vivo. This work proves that the multilayered conduits show great prospect in the long‐term nerve defects treatment due to easy manufacture and desired efficacy.

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The control of beads diameter of bead-on-string electrospun nanofibers and the corresponding release behaviors of embedded drugs

Cited by 65 publications

References 26 publications

Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer

Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer

Design of polyurethane fibers: Relation between the spinning technique and the resulting fiber topology

Electrospinning Multilayered Scaffolds Loaded with Melatonin and Fe₃O₄ Magnetic Nanoparticles for Peripheral Nerve Regeneration

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The control of beads diameter of bead-on-string electrospun nanofibers and the corresponding release behaviors of embedded drugs

Cited by 65 publications

References 26 publications

Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer

Knitted Silk Fibroin‐Reinforced Bead‐on‐String Electrospun Fibers for Sustained Drug Delivery Against Colon Cancer

Design of polyurethane fibers: Relation between the spinning technique and the resulting fiber topology

Electrospinning Multilayered Scaffolds Loaded with Melatonin and Fe3O4 Magnetic Nanoparticles for Peripheral Nerve Regeneration

Contact Info

Product

Resources

About

Electrospinning Multilayered Scaffolds Loaded with Melatonin and Fe₃O₄ Magnetic Nanoparticles for Peripheral Nerve Regeneration