The control of invasive<i>Candida</i>infection in very low birth weight infants by reduction in the use of 3rd generation cephalosporin

Chang, Yoon Hee; Choi, Il Rak; Shin, Won Sub; Lee, Jang Hoon; Kim, Yun Kyung; Park, Moon Sung

doi:10.3345/kjp.2013.56.2.68

Cited by 9 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Broad-spectrum antibiotic use has also been described as a risk factor for candidemia [2, 9, 10]. In our department, the majority of candidemia cases had received broad-spectrum antibiotics, such as carbapenems (72.5), and 53.6% of patients received multiple antibiotics.…”

Section: Discussionmentioning

confidence: 81%

Epidemiology of and risk factors for neonatal candidemia at a tertiary care hospital in western China

Chen

Jiang

et al. 2016

BMC Infect Dis

View full text Add to dashboard Cite

BackgroundThe prevalence and clinical characteristics of neonatal candidemia are poorly understood in western China. The aim of our study was to evaluate the epidemiological features of neonatal candidemia in the Liuzhou Maternity and Child Healthcare Hospital.MethodsA retrospective case-control study was conducted between January 2012 and November 2015. Electronic databases were reviewed and data on Candida species were isolated from blood cultures and candidemia incidence, risk factors, and mortality were extracted. Univariate and multivariate logistic regression analysis were performed to identify risk factors associated with candidemia.ResultsDuring the 4-year period, candidemia was identified in 69 newborns, for an incidence rate of 13.6 per 1000 admissions. Prolonged antibiotic therapy duration [odds ratio (OR), 95% confidence incidence (95% CI) = 1.06, 1.01–1.10], total parenteral nutrition [OR, 95% CI = 6.03, 2.10–17.30] and neurodevelopmental impairment (OR, 95% CI = 7.34, 1.18–45.80) were all associated with increased odds of candidemia development in infants (P value was 0.010, 0.001, 0.033, respectively). The overall mortality rate was 7.2% in the candidemia group.ConclusionsProlonged duration of antibiotic therapy, presence of total parenteral nutrition and neurodevelopmental impairment were the major risk factors associated with neonatal candidemia. This study highlights the importance of the early detection, diagnosis and treatment of neonatal candidemia.

show abstract

Section: Discussionmentioning

confidence: 81%

Epidemiology of and risk factors for neonatal candidemia at a tertiary care hospital in western China

Chen

Jiang

et al. 2016

BMC Infect Dis

View full text Add to dashboard Cite

show abstract

“…Many risk factors have been implicated in the pathogenesis of candidemia in infants, the most consistent one was prematurity, especially in very low birth weight groups [ 2 , 5 , 7 , 8 ]. The results of the present study indicated that low birth weight was significantly associated with persistent candidemia, as revealed by univariate analysis, although no statistical significance was found by multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The contributing factors in high-risk groups include prematurity, VLBW, catheter and endotracheal tube use, prolonged NICU stay, broad-spectrum antibiotic use and total parenteral nutrition [ 8 – 10 ]. Lack of specific signs or symptoms in the development of candidemia among VLBW infants results were in a high risk of fatality [ 8 ]. Early diagnosis is crucial for infection control and initiating effective treatment.…”

Section: Introductionmentioning

confidence: 99%

Persistent candidemia in very low birth weight neonates: risk factors and clinical significance

Ding

Jiang

et al. 2018

BMC Infect Dis

View full text Add to dashboard Cite

BackgroundThe prevalence and risk factors for persistent candidemia among very low birth weight infants are poorly understood. This study aimed to investigate the epidemiology of persistent candidemia over a 4-year period in a neonatal intensive care unit (NICU) in Liuzhou, China.MethodsWe retrospectively extracted demographic data, risk factors, microbiological results and outcomes of very low birth weight infants with candidemia in our hospital between January 2012 and November 2015. Persistent candidemia was defined as a positive blood culture for > 5 days. Logistic regression was used to identify risk factors associated with persistent candidemia.ResultsOf 48 neonates with candidemia, 28 had persistent candidemia. Both mechanical ventilation and intubation were significantly associated with increased rates of persistent candidemia (P = 0.044 and 0.004, respectively). The case fatality rate for the persistent candidemia group was 14.3%.ConclusionThe rate of persistent candidemia was high among very low birth weight neonates. Mechanical ventilation and intubation were the major factors associated with the development of persistent candidemia. This study highlights the importance of intensive prevention and effective treatment among neonates with persistent candidemia.

show abstract

“…Notably, numerous risk factors including broadspectrum antibiotics have been reported as predisposing factors for candidemia (18). The widespread use of antimicrobial agents can suppress the bacterial microbiota, paving the way for the dominance of Candida colonization (19).…”

Section: Discussionmentioning

confidence: 99%

Candidemia in the Neonatal Intensive Care Unit: Insights on Epidemiology and Antifungal Drug Susceptibility Patterns

Hassan

Yousef

Elhamed

et al. 2018

Arch Pediatr Infect Dis

View full text Add to dashboard Cite

Background: Being the culprit in 9%-13% of neonatal bloodstream infections (BSIs), candidemia has been escalating to worrisome levels in the past few decades. While C. albicans has traditionally been the most common isolate, non-albicans Candida spp. are currently gaining a foothold. Objectives: We endeavored to investigate the epidemiological features of neonatal candidemia with special emphasis on nonalbicans candidemia. Hence, we evaluated the incidence, risk factors, antifungal susceptibility, and case fatality rate of candidemia patients in the NICU. Methods: Blood samples were collected from 1296 neonates admitted to the NICU of a tertiary care hospital. Then, only neonates with positive blood cultures were enrolled. Incidence and risk factors of albicans and non-albicans candidemia were evaluated. The Etest was employed to determine the minimum inhibitory concentrations of fluconazole, itraconazole, voriconazole, amphotericin B, and caspofungin. Results: Out of 214 neonates with BSI, candidemia afflicted 32 neonates (15%). The predominant isolate was C. tropicalis (43.8%), followed by C. albicans (25%). Both antibiotic use and antifungal prophylaxis were contributing factors (P values of 0.02 and < 0.01, respectively). Susceptibility testing revealed that 87.5% of the retrieved Candida isolates were sensitive to amphotericin B, 81.25% to fluconazole, 75% to voriconazole, and 62.5% to itraconazole while 48.75% were sensitive to caspofungin. Conclusions: Neonatal candidemia often carries an ominous prognosis. The worldwide progressive shift towards non-albicans candidemia necessitates regular surveillance and monitoring of laboratory data. An epidemiological knowledge is critical in terms of preemptive management that should encompass disciplined infection control practices and a restrictive policy for antibiotic and antifungal prophylaxis.

show abstract

The control of invasiveCandidainfection in very low birth weight infants by reduction in the use of 3rd generation cephalosporin

Cited by 9 publications

References 35 publications

Epidemiology of and risk factors for neonatal candidemia at a tertiary care hospital in western China

Epidemiology of and risk factors for neonatal candidemia at a tertiary care hospital in western China

Persistent candidemia in very low birth weight neonates: risk factors and clinical significance

Candidemia in the Neonatal Intensive Care Unit: Insights on Epidemiology and Antifungal Drug Susceptibility Patterns

Contact Info

Product

Resources

About