The Copenhagen High-Risk Study Premorbid and Clinical Dimensions of Maternal Schizophrenia

Jørgensen, Anne Juul; Parnas, Josef

doi:10.1097/00005053-199006000-00005

Cited by 28 publications

(20 citation statements)

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“…For this analysis, individual ICD-10 symptoms were rated as: 0 = absent and 1 = present, according to Loftus et al [26]. In order to analyze the relationship between factors and sociodemographic and clinical variables, we used the method of some previous studies in item analysis [27][28][29]. This involved summing up the scores of the items of the questionnaires in each factor, to generate summary scores or symptom scores [27], and using these summary scores to compute t tests, one-way ANOVA and Pearson's correlations.…”

Section: Discussionmentioning

confidence: 99%

“…While we have no clear explanation for the lack of a psychosis factor, this finding has been reported in the literature. In a report of the Copenhagen high risk study [28], using the syndrome checklist of the PSE-9 in a conventional factor analysis, no dominant factor structure emerged. In an Italian study of 96 inpatient schizophrenics, using the SANS and SAPS, hallucinations did not load with delusions or any other symptom, and delusions loaded on 2 factors: on one factor with positive formal thought disorder and on another with anhedonia/asociality [33].…”

Section: Factor Analysismentioning

confidence: 99%

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Subtypes and Factors of Schizophrenia in an Acutely Ill Nigerian Sample

Ohaeri

Otote

2003

Psychopathology

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The objectives of the study were to assess the factors that would emerge from combining the ratings based on the Brief Psychiatric Rating Scale, Scale for Assessment of Negative Symptoms and ICD-10 diagnostic criteria for research, and examine the stability of these factors at the third month of treatment; to highlight the correlates of these factors, and to compare the factors yielded with those of previous reports. Principal component analysis with varimax rotation was performed on the ratings of 65 males and 37 females, aged 33.7 ± 8.4 years (SD), with a duration of illness of 7.3 ± 6.6 years. Five conceptually meaningful factors emerged, accounting for 61% of the variance. The first 2 factors (diminished expression or psychomotor poverty, and social dysfunction or disordered relating) are negative syndromes, followed by disorganization, catatonic and excitement syndromes. These factors did not endure at the third month. The disorganization syndrome was significantly correlated with duration of illness, while age was inversely correlated with the catatonic syndrome; however, the score on a measure of soft signs of neurological dysfunction was not significantly correlated with the negative syndromes. In spite of hallucinations and delusions not loading significantly on any factor, the individual factors were highly similar to those of previous studies. But the instability of the negative syndromes, coupled with the results of previous Nigerian short-term outcome studies, casts doubt on the validity of the concept of deficit schizophrenia in this and other treated noninstitutionalized schizophrenics in Nigeria.

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Section: Discussionmentioning

confidence: 99%

Section: Factor Analysismentioning

confidence: 99%

Subtypes and Factors of Schizophrenia in an Acutely Ill Nigerian Sample

Ohaeri

Otote

2003

Psychopathology

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“…There is also evidence that specific premorbid dimensions may selectively associate with dimensions of adult psychopathology, e.g. schizoid or schizotypal traits with negative symptoms; antisocial traits with disorganization [122][123][124]. Some clinical studies point to a symptomatic overlap between pre-schizotypal states in childhood and the Asperger's syndrome [125,126].…”

Section: Genetic-epidemiological Findings and The Diathesis-stress Modelmentioning

confidence: 99%

Cluster A Personality Disorders: A Review

Parnas

Licht

Bovet

2005

Personality Disorders

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“…Previous studies from our group and others have demonstrated a close relationship between premorbid personality dimensions and the symptomatology of acute episodes in samples of individuals with both chronic and recent-onset psychosis [14][15][16][17] . A common limitation in the literature on premorbid personality, including one of our previous studies 18 was that negative symptomatology was examined during the remission of the acute episode.…”

Section: Introductionmentioning

confidence: 99%

Premorbid Negative Symptoms in First-Episode Psychosis

et al. 2007

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Background and Objectives: Negative symptoms emerge in many patients with psychotic disorders long before the onset of the acute illness. These symptoms are often impossible to differentiate from certain Cluster A personality traits. Methods: The current study examines the extent to which premorbid negative symptoms are contributing factors to the development of primary and secondary negative symptomatology. Participants were 84 neuroleptic-naïve patients experiencing the occurrence of their first acute psychotic episode. Symptoms of psychopathology were assessed at two points: at admission and after remission of the acute episode. The Spanish version of the PANSS scale was administered. Premorbid personality assessment was considered as a proxy measure to evaluate each participant's negative symptomatology prior to the onset of the illness. Potential causes of secondary negative symptomatology, such as depression and extrapyramidal symptoms, were also examined. Results: 'Non-respondent' or 'residual' negative symptoms at discharge were significantly predicted by primary negative symptoms. To a lesser extent, disorganization and depressive symptoms at discharge and the Schizoid dimension of premorbid personality predicted residual negative symptoms. Conclusions: The severity of negative symptoms at the onset of the psychotic episode varied across patients. After controlling for 'respondent' and 'non-respondent' primary negative symptoms and other potential causes of negative symptoms, premorbid negative symptoms had a slight, but significant predictive relationship with residual negative symptoms.

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The Copenhagen High-Risk Study Premorbid and Clinical Dimensions of Maternal Schizophrenia

Cited by 28 publications

References 0 publications

Subtypes and Factors of Schizophrenia in an Acutely Ill Nigerian Sample

Subtypes and Factors of Schizophrenia in an Acutely Ill Nigerian Sample

Cluster A Personality Disorders: A Review

Premorbid Negative Symptoms in First-Episode Psychosis

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