The corneal melting point

Hossain, Parwez

doi:10.1038/eye.2012.136

Cited by 25 publications

(17 citation statements)

References 13 publications

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“…Topical nonsteroidal antiinflammatory drugs may also inhibit the healing process and should be avoided 29. In the event of stromal melting, use of topical collagenase inhibitors, such as N-acetylcysteine, and systemic administration of tetracycline or medroxyprogesterone may be considered 30–32. Use of topical antibiotic eye drops to prevent infection in eyes with NK at stages 2 and 3 is recommended.…”

Section: Managementmentioning

confidence: 99%

Diagnosis and management of neurotrophic keratitis

Sacchetti¹,

Lambìase²

2014

OPTH

204

246

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Neurotrophic keratitis (NK) is a degenerative disease characterized by corneal sensitivity reduction, spontaneous epithelium breakdown, and impairment of corneal healing. Several causes of NK, including herpetic keratitis, diabetes, and ophthalmic and neurosurgical procedures, share the common mechanism of trigeminal damage. Diagnosis of NK requires accurate investigation of clinical ocular and systemic history, complete eye examination, and assessment of corneal sensitivity. All diagnostic procedures to achieve correct diagnosis and classification of NK, including additional examinations such as in vivo confocal microscopy, are reviewed. NK can be classified according to severity of corneal damage, ie, epithelial alterations (stage 1), persistent epithelial defect (stage 2), and corneal ulcer (stage 3). Management of NK should be based on clinical severity, and aimed at promoting corneal healing and preventing progression of the disease to stromal melting and perforation. Concomitant ocular diseases, such as exposure keratitis, dry eye, and limbal stem cell deficiency, negatively influence the outcome of NK and should be treated. Currently, no specific medical treatment exists, and surgical approaches, such as amniotic membrane transplantation and conjunctival flap, are effective in preserving eye integrity, without ameliorating corneal sensitivity or visual function. This review describes experimental and clinical reports showing several novel and potential therapies for NK, including growth factors and metalloprotease inhibitors, as well as three ongoing Phase II clinical trials.

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Section: Managementmentioning

confidence: 99%

Diagnosis and management of neurotrophic keratitis

Sacchetti¹,

Lambìase²

2014

OPTH

204

246

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“…Pain management has a critical importance during the treatment of corneal ulcers in all species but there are differences of opinion regarding the use of topical antiinflammatory drugs. Some believe that antiinflammatory agents should be used to control pain and secondary/reflex uveitis, while others argue that these agents delay corneal epithelial healing [1,20]. In our study, nonsteroidal antiinflammatory drugs were not used due to the possibility of delaying corneal healing.…”

Section: Discussionmentioning

confidence: 84%

“…Inhibition of the collagenase enzymes (MMPs), which tend to destroy this tissue continuously, is one of the main objectives of melting ulcer treatment [19]. Various medical agents are proposed as inhibitors of MMPs in the treatment of melting ulcer [1]. EDTA, acetylcysteine, ascorbate, tetracycline, cysteine, sodium citrate, penicillin, and fresh autogenous serum have been successfully used for anticollagenase activity [1,6,20].…”

Section: Discussionmentioning

confidence: 99%

“…Various medical agents are proposed as inhibitors of MMPs in the treatment of melting ulcer [1]. EDTA, acetylcysteine, ascorbate, tetracycline, cysteine, sodium citrate, penicillin, and fresh autogenous serum have been successfully used for anticollagenase activity [1,6,20]. These agents are used to reduce proteases produced by inflammation cells and to promote corneal healing.…”

Section: Discussionmentioning

confidence: 99%

“…Corneal ulcers are important eye diseases with a risk of blindness if not treated [1,2]. While most of these ulcers are healed with appropriate treatment, some progress into corneal melting ulcers [3,4].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical management of infectious and noninfectious melting corneal ulcers in cats

Demir¹,

Altundağ²,

Karagözoğlu³

2020

Turk J Vet Anim Sci

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A melting ulcer, characterized by the stromal dissolution of the cornea, is an important eye lesion that develops due to various reasons and threatens vision. Restoration of this lesion, which causes loss of corneal transparency, requires aggressive medical and surgical treatment. In medical treatment, stromal degeneration is controlled with agents that support topical antibacterial and stromal healing. Surgical treatment is applied using various techniques to remove structures damaged due to the progression of corneal melting and to promote corneal healing. In this study, lamellar keratectomy and the third eyelid flap techniques were combined with topical medical therapy in 20 cat cases with melting ulcers. The aim of this study was to alert to general practitioners that this condition is an important cause of progressive eye loss and necessitates urgent intervention and to show that this treatment approach is easy to implement and has successful results.

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