The correlation between aldehyde dehydrogenase-1A1 level and tumor shrinkage after preoperative chemoradiation in locally advanced rectal cancer

Abstract

Abstract:This study was performed to determine the correlation between aldehyde dehydrogenase-1A1 (ALDH1A1) level and tumor shrinkage after chemoradiation in locally advanced rectal cancer. This is a retrospective study of 14 locally advanced rectal cancer patients with long course neoadjuvant chemoradiation. The ALDH1A1 level was measured using ELISA from paraffin embedded tissue. Tumor shrinkage was measured from computed tomography (CT) scan or magnetic resonance imaging (MRI) based on Response Evaluation Criteria in Solid Tumor v1.1 (RECIST v1.1). The mean of ALDH1A1 level was 9.014 ± 3.3 pg/mL and the mean of tumor shrinkage was 7.89 ± 35.7%. Partial response proportion was 28.6%, stable disease proportion was 50% and progressive disease proportion was 21.4%. There was a significantly strong negative correlation (r = -0.890, p < 0.001) between ALDH1A1 and tumor shrinkage. In conclusion, tumor shrinkage in locally advanced rectal cancer after preoperative chemoradiation was influenced by ALDH1A1 level. Higher level of ALDH1A1 suggests decreased tumor shrinkage after preoperative chemoradiation.

Tatalaksana Radioterapi pada Kekambuhan Lokal Kanker Ovarium Clear Cell

“…Relaps atau metastasis diperkirakan disebabkan oleh populasi baru kanker yang tumbuh dari sel punca kanker. Sel punca kanker merupakan subpopulasi sel yang memiliki sifat kemo dan radio resisten yang diekspresikan oleh marker seperti aldehyde dehidrogenaase1, efflux drug transporter atau mampu dorman pada fase G0 11,12 .…”