Premature Ejaculation (PE) is considered the most common sexual dysfunction that affects approximately 15%-30% of men over the age of 18. (Laumann et al., 1999). According to the definition of PE made by the International Society of Sexual Medicine (ISSM) in 2014, lifelong PE (a) ejaculation is always or almost always within 1 min before vaginal penetration or after vaginal penetration, (b) inability to delay ejaculation and (c) this situation creates frustration, bother, mental distress and sexual avoidance problems in the individual (Serefoglu et al., 2014). Acquired PE (APE) is separated from lifelong PE with the onset of the PE complaint in individuals with previous normal ejaculation performance and the ejaculation within approximately 3 min (Serefoglu et al., 2014). Despite its high prevalence, controversies about the definition, classification and hence treatment of PE still continue (Saitz & Serefoglu, 2015). All organs that function in the body need oxygen and a proper blood flow to achieve function. Many studies have determined that hypoxia, ischaemia and oxidative stress caused by arterial obstructive diseases such as atherosclerosis are among the factors affecting male sexual dysfunction (Bolat et al., 2017; Thompson et al., 2005). While disorders in serotonin biosynthesis play a role in lifelong PE, many factors are observed in APE aetiology. (Culha, Tuken et al., 2020). Gao et al. (2013) stated that patients suffering from PE suffer from comorbidity such as chronic prostatitis, hypertension, diabetes mellitus, cardiovascular (CV) diseases and