2014
DOI: 10.5152/eurjrheumatol.2014.032
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The correlation between ferritin level and acute phase parameters in rheumatoid arthritis and systemic lupus erythematosus

Abstract: Interestingly, we observed that ferritin level in RA patients was similar to the control group; however, it was a good parameter of disease activation. This is because a reduction in storage iron and resultant iron deficiency anemia are very common in RA patients.

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Cited by 26 publications
(17 citation statements)
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“…Serum ferritin is also recognized as an acute phase marker of inflammation. Some studies have explored whether elevated serum ferritin levels are associated with low-grade inflammation [32, 33], such as in chronic kidney disease [34], rheumatoid arthritis [35] and other autoimmune disorders [36]. These diseases exhibit low-grade inflammation and are mediated by oxidative stress, which is characterized by an imbalance between the generation of reactive oxygen species (ROS) and responses from the antioxidant defense system[37].…”
Section: Discussionmentioning
confidence: 99%
“…Serum ferritin is also recognized as an acute phase marker of inflammation. Some studies have explored whether elevated serum ferritin levels are associated with low-grade inflammation [32, 33], such as in chronic kidney disease [34], rheumatoid arthritis [35] and other autoimmune disorders [36]. These diseases exhibit low-grade inflammation and are mediated by oxidative stress, which is characterized by an imbalance between the generation of reactive oxygen species (ROS) and responses from the antioxidant defense system[37].…”
Section: Discussionmentioning
confidence: 99%
“…The following clinical observations may answer this question. First, IDA and FIDA frequently occur in autoimmune and inflammatory disorders such as systemic lupus erythematosus (SLE) [ 138 ], RA [ 139 , 140 ] and IBD [ 141 , 142 ]. These disorders are frequently associated with CKD, leading to ESRD [ 143 , 144 ].…”
Section: Impact Of Inflammation On Therapeutic Strategy With Iron mentioning
confidence: 99%
“…In addition, serum levels of ferritin and inflammation markers (CRP and IL-6) were higher in patients with active than in those with inactive SLE and controls [ 145 , 146 , 147 ] and IL-6 inversely correlated with Hb between active and inactive SLE [ 147 , 148 ]. Serum ferritin was positively correlated with SLE disease activity index, anti-dsDNA, IFN-γ, IL-6, proteinuria and renal dysfunction and negatively correlated with C3, C4 and Hb [ 140 , 145 , 146 , 147 ]. Thus, inflammation increases ferritin and worsens anemia in SLE [ 148 ].…”
Section: Impact Of Inflammation On Therapeutic Strategy With Iron mentioning
confidence: 99%
See 1 more Smart Citation
“…An association between ferritin concentrations and immune-mediated disease has been described in humans with diseases such as lupus erythematosus or rheumatoid arthritis, where the magnitude of increase in ferritin parallels the severity of clinical signs [ 23 – 25 ]. Likewise, dogs with immune mediated polyarthritis or immune mediated hemolytic anemia have high CRP values [ 26 29 ].…”
Section: Main Bodymentioning
confidence: 99%