The Correlation between Pulmonary Function Tests and the Salivary MMP-9 Activity among Chronic Obstructive Pulmonary Disease (COPD) Patients

Mulyadi, .; Sunnati,; Azhary, Mulkan

doi:10.1016/j.proche.2016.01.030

Cited by 3 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, neutrophil elastase acts by dissociating the binding of TIMP-1 to pro-MMP-9, which allows MMP-3 to activate pro-MMP-9 to become MMP-9 [ 10 ]. Our previous study revealed that salivary MMP-9 was not correlated with lung function in COPD patients, which prompted us to confirm whether salivary MMP-3 could be a viable biomarker associated with age and body mass index (BMI) at the onset of COPD [ 11 ]. This study aimed to investigate possible correlations between degenerative variables, such as age and BMI, and the level of salivary MMP-3 and TIMP-1 in Indonesian patients with COPD.…”

Section: Introductionmentioning

confidence: 99%

The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings

et al. 2018

Self Cite

View full text Add to dashboard Cite

ObjectivesIndividuals with chronic obstructive pulmonary disease (COPD) are usually > 50 years of age and have a low body mass index (BMI). An imbalance between matrix metalloproteinases (MMPs), including MMP-3, and tissue inhibitor of metalloproteinase 1 (TIMP-1), play a role in tissue degradation of lung extracellular matrix among COPD individuals. The purpose of the present study was to correlate age and/or BMI with salivary levels of MMP-3 and TIMP-1 among Indonesian subjects with COPD.ResultsThirty COPD patients were recruited to undergo thorough physical assessment and saliva collection for evaluating TIMP-1 and MMP-3 levels using commercially available kits enzyme-linked immunosorbent assay method. The mean (standard deviation) participant age and BMI were 60.5 (8.13) years, and 23.1 (4.75) kg/m2, respectively. Furthermore, the mean (standard deviation) of TIMP-1 and MMP3 levels were 23.99 (6.85) ng/mL and 1.81 (1.167) μM, respectively. Age was negatively correlated with MMP-3 (P < 0.05), but not with TIMP-1 levels. Age and BMI were not correlated with TIMP-1 level (P > 0.05). Collectively, this study demonstrated that age has a negative correlation with the protease marker (i.e. MMP-3), but not the anti-protease marker (TIMP-1). BMI was not correlated with either protease/anti-protease marker among Indonesian subjects with COPD.

show abstract

Section: Introductionmentioning

confidence: 99%

The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

Sputum and salivary protein biomarkers and point-of-care biosensors for the management of COPD

Dong

Santos

Yang

et al. 2020

Analyst

View full text Add to dashboard Cite

show abstract

Utility of Raman Spectroscopy in Pulmonary Medicine

Dzelve,

Legzdiņa,

Krūmiņa

et al. 2024

ARM

View full text Add to dashboard Cite

The Raman effect, or as per its original description, “modified scattering”, is an observation that the number of scattered light waves shifts after photons make nonelastic contact with a molecule. This effect allows Raman spectroscopy to be very useful in various fields. Although it is well known that Raman spectroscopy could be very beneficial in medicine as a diagnostic tool, there are not many applications of Raman spectroscopy in pulmonary medicine. Mostly tumor tissue, sputum and saliva have been used as material for analysis in respiratory medicine. Raman spectroscopy has shown promising results in malignancy recognition and even tumor staging. Saliva is a biological fluid that could be used as a reliable biomarker of the physiological state of the human body, and is easily acquired. Saliva analysis using Raman spectroscopy has the potential to be a relatively inexpensive and quick tool that could be used for diagnostic, screening and phenotyping purposes. Chronic obstructive pulmonary disease (COPD) is a growing cause of disability and death, and its phenotyping using saliva analysis via Raman spectroscopy has a great potential to be a dependable tool to, among other things, help reduce hospitalizations and disease burden. Although existing methods are effective and generally available, Raman spectroscopy has the benefit of being quick and noninvasive, potentially reducing healthcare costs and workload.

show abstract

The Correlation between Pulmonary Function Tests and the Salivary MMP-9 Activity among Chronic Obstructive Pulmonary Disease (COPD) Patients

Cited by 3 publications

References 14 publications

The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings

The correlation of age and body mass index with the level of both protease MMP3 and anti-protease TIMP-1 among Indonesian patients with chronic obstructive pulmonary disease: a preliminary findings

Sputum and salivary protein biomarkers and point-of-care biosensors for the management of COPD

Utility of Raman Spectroscopy in Pulmonary Medicine

Contact Info

Product

Resources

About