The Correlation Between Visual Field Defects and Focal Nerve Fiber Layer Thickness Measured With Optical Coherence Tomography in the Evaluation of Glaucoma

Abstract

Analysis of RNFL thickness in eyes with focal glaucomatous visual field defects showed good structural and functional correlation with OCT. OCT contributes to the identification of focal defects in the RNFL of glaucoma patients.

A Study of Correlation of Visual Field Changes by Humphrey’s Automated Field Analyser With Retinal Nerve Fiber Layer (Rnfl) Defects on Optical Coherence Tomography (Oct) in Primary Open Angle Glaucoma (Poag)

“…Similar results were found in C. Ajtony et al 9 (77.99 ± 17.06) study, but not with that of Yalvac IS et al 12 (62.90 ± 16.56) and Sujatasubbiah et al 10 studies.…”

Correlation of localized glaucomatous visual field defects and spectral domain optical coherence tomography retinal nerve fiber layer thinning using a modified structure–function map for OCT

“…[2][3][4][5][6]12,14,[16][17][18] However, most of these studies used the Stratus time Correlation of localized glaucomatous VF defects and SD-OCT RNFL thinning H Wu et al domain OCT to measure RNFL thickness. [2][3][4]6,13,14,16,17 Although in two of these studies, SD-OCT was used to evaluated RNFL thickness, 5,18 the structure-function correspondence maps made in those studies correlated VF test points to regions of the ONH. In the present study, we created a modified OCT-based structurefunction map that shows significant correlation between localized areas of VF loss and SD-OCT measurements of RNFL thinning.…”

“…SAP provides a few parameters (ie, raw threshold values (VF sensitivity), total deviation values, pattern deviation values, MD, and PSD), but which are best fit for functional assessments and statistical analyses? In previous structure-function relationship studies where localized VF defects were correlated to RNFL thickness changes, VF parameters used included mean raw threshold values, 2,9,12,14,15,17 total deviation values, 1,[3][4][5]13,16,18 and pattern deviation values. 16 Total deviation values, which are age-corrected, are less influenced by age than raw threshold values, and they may be more sensitive to detect early diffuse loss compared with pattern deviation values.…”

“…Significant correlations have been described between glaucomatous structural changes of the optic disc and/or retinal nerve fiber layer (RNFL) and functional changes on VF testing. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Determining whether there is good correlation between localized VF defects and localized RNFL defects may be important in deciding whether glaucomatous progression has occurred and in understanding the pathogenesis of the disease.…”

“…Weber's method has since been used by others. 6,16 Because retinal nerve fibers do not project radially to the optic disc but rather arc into the optic disc, best RNFL-VF structure-function maps should not be assumed to be the same as ONH-VF structure-functions maps. Therefore, for this study, we modified and used a map established by Kanamori et al 2 who evaluated the relationship between VF sensitivity and RNFL thickness as measured by Stratus OCT (Carl Zeiss Meditec, Dublin, CA, USA).…”