The correlation between women’s various gynaecological diseases to ovarian cancer in Sulaimaniyah City, Iraq

Karim, Soz Mustafa Hagi; Fattah, Chro Najmadin

doi:10.1177/03000605231158949

Cited by 2 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have suggested that elevated serum levels of gonadotropins, including β-HCG, may be associated with ovarian cancer [2][3][4]. However, the use of β-HCG as a diagnostic biomarker in women of reproductive age remains controversial due to various concerns and limitations [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Beta-HCG levels and ovarian ultrasonography results among non-pregnant women of reproductive age in Port Harcourt, Nigeria

Agonsi,

Anacletus,

Aluko

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Certain ovarian cancers previously more common in postmenopausal women are now increasingly observed in women of reproductive age. The research on using β-HCG as a diagnostic biomarker for ovarian cancer in women of reproductive age is ongoing. This particular study assessed the level of serum β-HCG in non-pregnant women of reproductive age and determined its potential association with suspicious ovarian ultrasonography results in Port Harcourt, Nigeria. Material and methods This study utilized a descriptive-analytic design on a quota sample of 224 diagnostic case notes of women aged 18-40. Data collection involved a data extraction form. Data analysis employed descriptive statistics, Chi-square, Fisher's exact test, and Odds Ratio at 95% confidence and 5% significance levels. Results About 5.8% of the participants exhibited detectable levels of serum β-HCG above 5 IU/L (World Health Organization reference) at a mean concentration of 5.87 (±1.75) IU/L. About 4% of the participants had suspicious ovarian lesions identified through ultrasonography. Participants with elevated serum β-HCG levels above the WHO reference were 59 times more likely to have suspicious ovarian lesions, with an odds ratio of 59.4 (95%CI: 12.3–287.8, p = 0.001). There was a significant association between serum β-HCG level and age (p = 0.041) as well as parity (p < 0.001). Conclusions This study demonstrated that Serum β-HCG levels above the WHO reference were associated with suspicious ovarian lesions. Non-pregnant women should undergo serum β-HCG testing at least yearly to facilitate the early detection of ovarian anomalies.

show abstract

Section: Introductionmentioning

confidence: 99%

“…The β-HCG is a glycoprotein known to be synthesized by the foetal trophoblast and released into maternal blood. Nonetheless, recent research report that some cancers do produce β-HCG [2,6]. Clinical laboratory protocols enable the measurement of β-HCG in blood or serum specimens [7].…”

Section: Introductionmentioning

confidence: 99%