The Correlation Coefficient: An Overview

Asuero, Agustín G.; Sayago, Ana; González, A. Gustavo

doi:10.1080/10408340500526766

Cited by 1,001 publications

(504 citation statements)

References 59 publications

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“…43,44 These results shown in Table 4 indicate that correlations between antioxidant activity and total content of bioactive compounds assays exhibit differences. It was observed that the correlation coefficient (r = 0.87) between the FRAP and deoxyribose antioxidant assays was significantly different (P < .001) and similarly for the FRAP and ABTS assays (r = 0.9105, P < .001) and for deoxyribose and ABTS assays (r = 0.873, P < .001).…”

Section: Ramos-escudero Et Almentioning

confidence: 81%

Purple Corn (Zea maysL.) Phenolic Compounds Profile and Its Assessment as an Agent Against Oxidative Stress in Isolated Mouse Organs

Ramos-Escudero

Muñoz

Alvarado-Ortíz

et al. 2012

Journal of Medicinal Food

138

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This study was designed to determine the contents of total polyphenols, flavonoids, flavonols, flavanols, and anthocyanins of purple corn (Zea mays L.) extracts obtained with different methanol:water concentrations, acidified with 1% HCl (1 N). Another objective was to determine the antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 0 -azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), and deoxyribose assay, individual phenolic compounds by high-performance liquid chromatography (HPLC), and endogenous antioxidant enzyme (superoxide dismutase [SOD], catalase [CAT], and total peroxidase [TPX]) activity and lipid peroxidation activity (thiobarbituric acidreactive substances [TBARS] assay) in isolated mouse organs. Overall, the highest total content of polyphenols, anthocyanins, flavonoids, flavonols, and flavanols was obtained with the 80:20 methanol:water extract, acidified with 1% HCl (1 N). The 50% inhibitory concentration values obtained by the DPPH and ABTS assays with this extract were 66.3 lg/mL and 250 lg/mL, respectively. The antioxidant activity by the FRAP assay was 26.1 lM Trolox equivalents/g, whereas the deoxyribose assay presented 93.6% inhibition. Because of these results, the 80:20 methanol:water extract, acidified with 1% HCl (1 N), was used for the remaining tests. Eight phenolic compounds were identified by HPLC: chlorogenic acid, caffeic acid, rutin, ferulic acid, morin, quercetin, naringenin, and kaempferol. Furthermore, it was observed that the purple corn extract was capable of significantly reducing lipid peroxidation (lower malondialdehyde [MDA] concentrations by the TBARS assay) and at the same time increasing endogenous antioxidant enzyme (CAT, TPX, and SOD) activities in isolated mouse kidney, liver, and brain. On the basis of the results, it was concluded that the purple corn extract contained various bioactive phenolic compounds that exhibited considerable in vitro antioxidant activity, which correlated well with the decreased MDA formation and increase in activity of endogenous antioxidant enzymes observed in the isolated mouse organs. This warrants further in vivo studies with purple corn extracts to assess its antioxidant activity and other bioactivities.KEY WORDS: antioxidant activity endogenous antioxidant enzymes isolated mouse organs oxidative stress phenolic compounds purple corn Zea mays L.

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Section: Ramos-escudero Et Almentioning

confidence: 81%

Purple Corn (Zea maysL.) Phenolic Compounds Profile and Its Assessment as an Agent Against Oxidative Stress in Isolated Mouse Organs

Ramos-Escudero

Muñoz

Alvarado-Ortíz

et al. 2012

Journal of Medicinal Food

138

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“…The correlation observed between the ACE inhibitors' renal elimination data and their in silico molecular descriptors (lipophilicity parameter (AClogP) and constitutional parameter (molecular mass) or geometric descriptor (volume value)) can be considered good, as proposed by Asuero et al (34), due to the limited number of compounds. These correlations confirmed the calculation of descriptors as the technique suitable for evaluation of renal elimination of the selected compounds.…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of Angiotensin-Converting Enzyme Inhibitors in Renal Elimination with Selected Molecular Descriptors

Trbojević

Odović

Trbojević-Stanković

et al. 2017

Serbian Journal of Experimental and Clinical Research

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Angiotensin-converting enzyme (ACE) inhibitors modulate the function of the renin-angiotensin-aldosterone system, and they are commonly prescribed antihypertensive drugs especially in patients with renal failure. In this study, the relationships between several molecular properties of eight ACE inhibitors (enalapril, quinapril, fosinopril, ramipril, benazepril, perindopril, moexipril, trandolapril) SAŽETAK Inhibitori enzima koji konvertuje angiotenzin (ACE) modifi kuju funkciju renin-angiotenzin-aldosteron sistema i predstavljaju često propisane lekova za sniženje pritiska, posebno kod pacijenata sa insufi cijencijom bubrega. U ovom radu, za osam odabranih ACE inhibitora (enalapril, kvinapril, fosinopril, ramipril, benazepril, perindopril, moeksipril, trandolapril)

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“…Then, when the correlation coefficient values reach at least 0.999 the linearity can be assumed in the concentration range for which standard solutions had been prepared during the calibration procedure. However, this parameter is mostly used, but correlation coefficient (r) is neither a proof of linearity nor suitable for quantitative measurement [19,25,[48][49][50][51][52]. Correlation coefficient (r) just indicates the extent of the relationship between the dependent and independent variables such as the electroanalytical response and the electroactive compound concentration.…”

Section: Linearitymentioning

confidence: 99%

“…A lack of significance means that there are no detectable general matrix effects either in pharmaceutical dosage forms or in biological samples. If the calibration is not linear, a more complex technique for significance tests [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][48][49][50][51][52]. However, using the electroanalytical methods this kind of interferences are not detected because of the electro-inactive nature of the excipients of pharmaceuticals and most of the endogenous substances of biological media.…”

Section: Linearitymentioning

confidence: 99%

The Role of and the Place of Method Validation in Drug Analysis Using Electroanalytical Techniques

Gümüştaş¹,

Özkan²

2014

TOACJ

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Electroanalytical methods are chosen for the sensitive analysis of pharmaceutically active compounds in their dosage forms and biological samples. Electroanalytical method validation is the process used to confirm that the determination procedure employed for a specific test is suitable for its intended use like other analytical methods. Results from electroanalytical method validation can be used to judge the quality, applicability, accuracy, reliability and consistency of analytical results; it is an integral part of any analytical procedure. Also in electroanalytical drug analysis, important decisions are taken which are based on data obtained from real samples. Validation parameters help assure that the electroanalytical methods ensure the correct identity, strength, quality, accurate, precise, selective, robust and sensitive. A well-defined and well-documented validation process provides regulatory agencies with evidence that the system and method suitable for its intended use. Method validation is an essential component of the measures that a laboratory should implement to permit it to produce reliable electroanalytical data.

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The Correlation Coefficient: An Overview

Cited by 1,001 publications

References 59 publications

Purple Corn (Zea maysL.) Phenolic Compounds Profile and Its Assessment as an Agent Against Oxidative Stress in Isolated Mouse Organs

Purple Corn (Zea maysL.) Phenolic Compounds Profile and Its Assessment as an Agent Against Oxidative Stress in Isolated Mouse Organs

The Evaluation of Angiotensin-Converting Enzyme Inhibitors in Renal Elimination with Selected Molecular Descriptors

The Role of and the Place of Method Validation in Drug Analysis Using Electroanalytical Techniques

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