Background: The association between vitamin D deficiency, proteinuria, and diabetic nephropathy has been shown. This study will examine the relationship between vitamin D deficiency and angiographic coronary artery disease (CAD) severity in patients with type 2 diabetes mellitus (T2DM) increased Urinary Albumin/Creatinine Ratio (UACR).
Method: Patients with diabetes referred for coronary angiography were included in this study. Their baseline information was recorded, and the blood and urine samples were sent for laboratory evaluation. Patients then underwent angiography.
Results: The study included 129 patients. The mean age of the patients was 59.35 ±9.2 years old. A coronary angiography revealed that 62.8% of them had coronary artery involvement. Patients with CAD were divided into three groups: Single-vessel disease (SVD), two-vessel disease (2VD), and three-vessel disease (3VD), and their distribution was 20%, 17%, and 24%, respectively. Only 17.1% of patients had sufficient vitamin D levels, and 40% had vitamin D deficiency. There was a significant relationship between vitamin D deficiency and proteinuria, coronary artery involvement, and its severity. In patients with very severe vitamin D deficiency (vitamin D level <10), 77.8% of them had an elevated Urine Albumin/Creatinine ratio (UACR).
Conclusion:
Vitamin D deficiency is associated with increased proteinuria, the number of involved coronary vessels, and the severity of coronary artery stenosis. Therefore, it is recommended therapeutic and preventive role of vitamin D in improving and reducing renal and cardiovascular disease be investigated.