The correlation of D-dimer levels with patient outcomes in acute ischemic cerebrovascular disease complicating coronary heart disease

Wang, Yanling; Hafeez, Adam; Meng, Fanqi; Zhang, Ruihua; Wang, Xuemei; Chen, Xiaomeng; Kong, Qi; Du, Hongguang; Ma, Xiaoli

doi:10.1080/01616412.2016.1187829

Cited by 10 publications

(7 citation statements)

References 48 publications

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“…A Canadian study by Kim et al [37] reported the prognostic value of plasma D-dimer level in patients with noncardioembolic stroke. In a study of a Chinese population with complicating coronary heart disease, the result indicated that higher plasma D-dimer levels had a worse outcome within 90 days after the initial onset of AIS [38]. A Swiss study by Hsu et al reported that a high plasma D-dimer levels indicates an unfavorable outcome in patients with AIS receiving intravenous thrombolysis [39].…”

Section: Discussionmentioning

confidence: 99%

Elevated plasma D-dimer levels are associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study

Yao

Tian

et al. 2019

BMC Neurol

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Background Elevated levels of plasma D-dimer increase the risk of ischemic stroke, stroke severity, and the progression of stroke status, but the association between plasma D-dimer level and functional outcome is unclear. The aim of this study is to investigate whether plasma D-dimer level is a determinant of short-term poor functional outcome in patients with acute ischemic stroke (AIS). Methods This prospective study included 877 Chinese patients with AIS admitted to Renmin Hospital of Wuhan University within 72 h of symptom onset. Patients were categorized by plasma D-dimer level: Quartile 1(≤0.24 mg/L), Quartile 2 (0.25–0.56 mg/L), Quartile 3 (0.57–1.78 mg/L), and Quartile 4 (> 1.78 mg/L). The medical record of each patient was reviewed, and demographic, clinical, laboratory and neuroimaging information was abstracted. Functional outcome at 90 days was assessed with the modified Rankin Scale. Results Poor outcome was present in 302 (34.4%) of the 877 patients that were included in the study (mean age, 64 years; male, 68.5%). After adjustment for potential confounding variables, higher plasma D-dimer level on admission was associated with poor outcome (adjusted odds ratio 2.257, 95% confidence interval 1.349–3.777 for Q4:Q1; P trend = 0.004). According to receiver operating characteristic (ROC) analysis, the best discriminating factor for poor outcome was a plasma D-dimer level ≥ 0.315 mg/L (area under the ROC curve 0.657; sensitivity 83.8%; specificity 41.4%). Conclusion Elevated plasma D-dimer levels on admission are significantly associated with poor outcome after admission for AIS, suggesting the potential role of plasma D-dimer level as a predictive marker for short-term poor outcome in patients with AIS.

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Section: Discussionmentioning

confidence: 99%

Elevated plasma D-dimer levels are associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study

Yao

Tian

et al. 2019

BMC Neurol

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“…If the plasma D-dimer test is negative, the diagnosis of acute VTE can be ruled out; if the plasma D-dimer test is positive, the diagnosis of VTE can be con rmed by the symptoms and an ultrasound examination 8 . There have also been many relevant studies in some cardiovascular diseases, such as atrial brillation [18][19][20] , coronary heart disease 13,21,22 , stroke 23,24 and aortic dissection [25][26][27] , and D-dimer can even be used as a predictor of the diagnosis and prognosis of such diseases [28][29][30][31] .…”

Section: Discussionmentioning

confidence: 99%

Change Trend of Plasma D-Dimer Level and Its Clinical Value in Patients with Acute Lower Limb Ischemia Treated by Catheter-Directed Thrombolysis

Liu¹,

Xie²,

Zheng³

et al. 2021

Preprint

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To investigate the correlation between plasma D-dimer levels before and after catheter-directed thrombolysis (CDT) in acute lower limb ischemia (ALI) and lower limb arterial recanalization and the clinical value of the change trend of plasma D-dimer. A retrospective review of all patients who received CDT for the treatment of ALI between January 2013 and December 2019 was carried out. The change trend of plasma D-dimer of the patients during thrombolysis was statistically analyzed using repeated measures ANOVA. A total of 150 patients were included in the analysis. Among them, 3 days of CDT was ineffective in 41 cases, effective in 33 cases and markedly effective in 76 cases. The plasma D-dimer levels of the patients were significantly different between pre- and post-thrombolysis (F = 23.856, P = 0.000). There was an interaction effect between the measured time factors and thrombolysis efficacy (F=13.991, P=0.000). The change trends of plasma D-dimer levels in the three groups were statistically significant (F = 3.246, P = 0042). The plasma D-dimer level changes regularly during CDT for ALI. We can predict the efficacy of CDT and guide adjustments of the therapeutic regimen according to the trend of D-dimer changes during thrombolysis to obtain better clinical effects.

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“…D-dimer has been widely used in the diagnosis of VTE 8 , 17 , 18 . There have also been many relevant studies in some cardiovascular diseases, such as atrial fibrillation 19 – 21 , coronary heart disease 14 , 22 , 23 , stroke 24 , 25 and aortic dissection 26 – 28 , and D-dimer can even be used as a predictor of the diagnosis and prognosis of such diseases 29 – 32 .…”

Section: Discussionmentioning

confidence: 99%

The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis

Liu

Xie

Zheng

et al. 2021

Sci Rep

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To investigate the change trends of plasma D-dimer during catheter-directed thrombolysis (CDT) in acute lower limb ischemia (ALI) patients and their clinical value. A retrospective review of patients with ALI who received CDT was carried out. The repeated measurements of plasma D-dimer were analyzed by generalized estimating equations (GEEs) and the change trends of D-dimer were analyzed by spline regression approach. A total of 150 patients were included. Among them, 3 days of CDT was ineffective in 41 cases, effective in 33 cases and markedly effective in 76 cases. The results of GEEs analysis showed that serum D-dimer changed significantly with time (time effect, P < 0.001). Serum D-dimer levels of patients with different treatment outcomes were different after treatment (group effect, P < 0.001), and serum D-dimer levels in these three groups showed different trends over time (group*time effect, P < 0.001). The different trends in serum D-dimer level with time after treatment in the three groups could be directly seen in the spline regression curve (P < 0.001). The plasma D-dimer changes regularly during CDT for ALI. We can predict the efficacy of CDT and guide adjustments of the therapeutic regimen according to the trend of D-dimer changes during thrombolysis.

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The correlation of D-dimer levels with patient outcomes in acute ischemic cerebrovascular disease complicating coronary heart disease

Cited by 10 publications

References 48 publications

Elevated plasma D-dimer levels are associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study

Elevated plasma D-dimer levels are associated with short-term poor outcome in patients with acute ischemic stroke: a prospective, observational study

Change Trend of Plasma D-Dimer Level and Its Clinical Value in Patients with Acute Lower Limb Ischemia Treated by Catheter-Directed Thrombolysis

The plasma D-dimer trends and their value in acute lower limb ischemia patients treated by catheter directed thrombolysis

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