The Correlation of Routine Hematological Parameters with In-hospital Mortality and Length of Hospital Stay in Patients with Large Middle Cerebral Artery Infarction

Güneş, Muzaffer

doi:10.7759/cureus.7886

Cited by 2 publications

(4 citation statements)

References 22 publications

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“…In the present study, we found that in addition to the LDL-C to lymphocyte ratio, RDW-SD predicts mortality in patients with ACI. This result is consistent with that of previous studies [ 5 , 8 ].…”

Section: Discussionsupporting

confidence: 94%

“…Therefore, investigators have been focusing on new and effective prognostic factors relating to ACI. In recent studies, hematological parameters, such as neutrophil to lymphocyte ratio [ 5 ], monocyte to high-density lipoprotein cholesterol (HDL-C) ratio [ 6 ], C-reactive protein to albumin ratio [ 7 ], red blood cell distribution width (RDW) [ 8 ], and the neutrophil to eosinophil ratio [ 9 ], were found to be associated with the prognosis of ACI.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, high LDL-C levels are associated with clinical deterioration in patients with ACI [ 12 ]. In recent years, studies have found that during the acute period, blood lymphocyte counts of patients with ACI who died were lower than those of patients who survived [ 8 ]. Therefore, the LDL-C to lymphocyte ratio can be a better and different expression of the increased LDL-C level and reduced lymphocyte count in the blood.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Predictive Marker for In-Hospital Mortality in Acute Cerebral Infarction: Low-Density Lipoprotein Cholesterol to Lymphocyte Ratio

Güneş¹,

Büyükgöl²

2020

Cureus

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Objectives Neutrophil to eosinophil ratio, neutrophil to lymphocyte ratio, C-reactive protein to albumin ratio, and red blood cell distribution width (RDW) have been studied in patients with acute cerebral infarction (ACI). However, the low-density lipoprotein cholesterol (LDL-C) to lymphocyte ratio has never been studied. Hence, our objective was to study the LDL-C to lymphocyte ratio with regard to in-hospital mortality rates of patients with ACI. Materials and methods We retrospectively examined our patients diagnosed with ACI between January 2015 and December 2018. The patients' clinical data and imaging and laboratory results during the acute period were retrieved from our database and saved for statistical analysis. The receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive value of the variables and to calculate the cut-off values. Results A total of 172 patients with ACI, including 43 patients who died and 129 patients who survived in the hospital, were included in the study. The median age of the patients who died was significantly higher than that of those who survived (p: <0.001). Median triglyceride level, LDL-C to lymphocyte ratio, and RDW-SD values were significantly higher in patients who died (p = 0.017, p: <0.001, and p = 0.003, respectively). Areas under the ROC curve were found to be as follows: LDL-C to lymphocyte ratio: 0.774 (95% CI: 0.697-0.851), RDW-SD: 0.562 (95% CI: 0.456-0.669), and triglyceride level: 0.621 (95% CI: 0.531-0.732). The cut-off value of the LDL-C to lymphocyte ratio was 59.71 (sensitivity: 79.1%; specificity: 58.1%). Conclusions The LDL-C to lymphocyte ratio can be used as a marker to predict in-hospital mortality in patients with ACI. We recommend further studies to verify our findings.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Novel Predictive Marker for In-Hospital Mortality in Acute Cerebral Infarction: Low-Density Lipoprotein Cholesterol to Lymphocyte Ratio

Güneş¹,

Büyükgöl²

2020

Cureus

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“…These found that RDW is associated with 1-month mortality in patients with malignant middle cerebral artery infarction 19 and that high RDW is a poor prognostic factor. 20 However, to our knowledge, there is no study on the relationship between RDW and the prognosis of the stroke subtype—SAO. Moreover, previous studies investigated the prognostic indicators of mortality and poor function, but there were no studies related to recurrence.…”

Section: Introductionmentioning

confidence: 98%

Association of Red Blood Cell Distribution Width with Stroke Prognosis Among Patients with Small Artery Occlusion: A Hospital-Based Prospective Follow-Up Study

Guan¹,

Zuo²,

Jia³

et al. 2022

IJGM

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Objective Stroke is the leading cause of mortality and disability worldwide. However, there is no study on the relationship between red blood cell distribution width and the prognosis of small artery occlusion, which is a stroke subtype. This study aimed to assess the association of red blood cell distribution width at admission with outcomes among patients with small artery occlusion. Methods In this hospital-based follow-up study, all included patients were diagnosed with small artery occlusion. Outcomes included death, recurrence, and dependency at 3, 12, and 36 months after stroke onset. Multivariate analysis was performed to explore the association of red blood cell distribution width with stroke outcomes. Results This study included 1576 patients with small artery occlusion who were followed up at 3, 12, and 36 months. For every unit increase in red blood cell distribution width, the risk of stroke recurrence and dependency increased by 5.1% (95% CI 1.002–1.102, P=0.039) at 3 months after stroke onset. At the 12-month follow-up, for every unit increase in red blood cell distribution width, the risk of stroke recurrence increased by 3.4% (95% CI 1.000–1.069, P=0.047). However, the relationship between red blood cell distribution width and mortality rate was not significant at 36 months after stroke onset after adjustment of covariates. Conclusion Red blood cell distribution width is an important hematological index of small artery occlusion. It may be used to predict the recurrence of acute ischemic stroke in small artery occlusion. Therefore, patients with higher baseline values of red blood cell distribution width may need more risk factor control to reduce recurrence and dependency.

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The Correlation of Routine Hematological Parameters with In-hospital Mortality and Length of Hospital Stay in Patients with Large Middle Cerebral Artery Infarction

Cited by 2 publications

References 22 publications

A Novel Predictive Marker for In-Hospital Mortality in Acute Cerebral Infarction: Low-Density Lipoprotein Cholesterol to Lymphocyte Ratio

A Novel Predictive Marker for In-Hospital Mortality in Acute Cerebral Infarction: Low-Density Lipoprotein Cholesterol to Lymphocyte Ratio

Association of Red Blood Cell Distribution Width with Stroke Prognosis Among Patients with Small Artery Occlusion: A Hospital-Based Prospective Follow-Up Study

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