The Correlation of SKA2 with Cortisol, IL-1β and Anxiety in Pregnant Women with the Risk of Preterm Delivery

Genes involved in regulating the hypothalamic–pituitary–adrenal (HPA) axis, including the glucocorticoid receptor (GR), are linked to various stress-related psychopathologies including bipolar disorder as well as other mood and trauma-related disorders. The protein product of the cell cycle gene, SKA2, is a GR interaction partner in peripheral cells. However, the precise roles of SKA2 in stress and GR signaling in the brain, specifically in nonreplicating postmitotic neurons, and its involvement in HPA axis regulation remain unclear. Here, we demonstrate, using diverse in vitro cell assays, a mechanism by which SKA2 promotes GR signaling through enhancing GR–FKBP4 interaction leading to dissociation of FK506-bindingprotein 51 (FKBP5) from the complex. FKBP4 and FKBP5 are cochaperones known to regulate GR function in opposite directions. Notably in mice, SKA2 in Crh + neurons of the paraventricular nucleus of the hypothalamus is crucial for HPA axis responsiveness and for maintaining the negative feedback loop underlying allostasis. Moreover, we show that SKA2 expression is increased in postmortem human hippocampus and amygdala from individuals with BD. Our study highlights a critical role of SKA2 in HPA axis function, adds to the understanding of the molecular basis of stress-related psychiatric disorders, and points to potential targets for intervention.

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The relationship between crying of premature infants with Monro-kellie hypothesis and increase of ventricular CSF Based on Doppler ultrasound findings

Ijabi

Tehranian

Afrisham

et al. 2022

Preprint

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Introduction: Infant crying causes an increase in intracranial pressure which is equivalent to a decrease in CSF and also a decrease in CSF before ischemic and hemorrhagic strokes observed. The object of this study is to evaluate the effect of crying on premature infant brain pressure and the effect of crying on brain autoregulation. Method: In a case-control study, the participants were 53 premature infants with the ability to cry and 43 non-crying premature. Apgar score and after birth blood gases were estimated, and 200 µl capillary samples were collected from the heel for assessment of blood gases before,during and after crying. A transcranial Doppler device used to measure cerebral blood flow volume (CBFV) levels and compared in three sections during, before, and after crying. Results: The CO2 higher level was during crying in comparison with after and before crying (P<0.001). The brain volume was enlarger during crying than after and before crying, as well (P<0.001). The Doppler ultrasound results showed that the higher resistive index (RI) and pulsatility index (PI) occurred during crying than after and before crying (P<0.001). There was the lowest end-diastolic velocity (EDV) and Peak systolic velocity (PSV) during crying than after and before crying (P=0.001).Conclusion: The results suggest that the brain volume has increased during crying, which is associated with simultaneous entry of CSF. In intracranial hemorrhage (IH), there is a decrease in CSF which is accompanied by a decrease in brain activity. Therefore, crying with an increased CSF and brain magnetic activity can probably prevent IH.

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The Correlation of SKA2 with Cortisol, IL-1β and Anxiety in Pregnant Women with the Risk of Preterm Delivery

Cited by 5 publications

References 49 publications

A model of post-traumatic growth and stress reaction in China under COVID-19: A mediating instrument for trauma and disaster reduction

A model of post-traumatic growth and stress reaction in China under COVID-19: A mediating instrument for trauma and disaster reduction

SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4–FKBP5 interactions in neurons

The relationship between crying of premature infants with Monro-kellie hypothesis and increase of ventricular CSF Based on Doppler ultrasound findings

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