The cosmetic application of cyanobacterial secondary metabolites

Nowruzi, Bahareh; Sarvari, Gisoo; Blanco, Saúl

doi:10.1016/j.algal.2020.101959

Cited by 62 publications

(34 citation statements)

References 141 publications

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“…Ethanolic extract of Spirulina platensis keeps significant anti-inflammatory activity in both carrageenan induced raw paw edema test. Spirulina could control the undesirable effects of acetic acid persuaded ulcerative colitis in rats demonstrated by raising the activity of anti-oxidant enzyme CAT and SOD in addition to GSH content with, considerable depletion in lipid peroxidation makes MDA and protein carbonyl inclusion to control prostaglandins as well as pro inflammatory cytokines (Nowruzi, Sarvari, & Blanco, 2020b;.…”

Section: Anti-inflammatory Property Of Spirulinamentioning

confidence: 99%

Bioactive Properties of Spirulina: A Review

Anvar¹,

Nowruzi²

2021

microb bioacts

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Spirulina is a single-cell protein rich in all essential nutrients and vitamins and can be used to produce functional food. Spirulina is a single-cell protein rich in all essential nutrients and vitamins and can be used to produce functional food. In fact, one of the most important problems in the food industry is the use of synthetic food additives that increase the risk of cancer. Therefore, efforts are being made around the world today to isolate new and safe antioxidants from natural sources. Among these, the natural products of cyanobacteria are an important source of new drug compounds. Natural bioactive products not only have medicinal value themselves but are also used as building models to create synthetic analogs. The chemical composition of Spirulina includes protein (70-55%), carbohydrates (25-25%), essential fatty acids (18%), vitamins, minerals, and pigments such as carotene, chlorophyll A and phycocyanin. Obviously, the introduction of valuable properties of cyanobacteria Spirulina can be a suitable substitute for many antimicrobial compounds and synthetic antioxidants that not only pose no risk to the consumer but can also improve consumer health. In this review, we have discussed the important nutrient, bioactive properties, and immunological applications of Spirulina. The current research suggests that spirulina supplementations have been accepted by global accreditation as a safe nutritional and dietary supplement.

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Section: Anti-inflammatory Property Of Spirulinamentioning

confidence: 99%

Bioactive Properties of Spirulina: A Review

Anvar¹,

Nowruzi²

2021

microb bioacts

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“…Cyanobacteria and microalgae are prolific sources of natural bioactive compounds with different areas of application 22 . It is known that cyanobacteria and microalgae synthesise pigments, lipids (polyunsaturated fatty acids -PUFAs, hydrocarbons), proteins, polysaccharides (cellulose, alginates, starch), and other compounds, with proven bioactivities in the pharmaceutical, energy, nutrition and cosmetic fields 24,26,27 .…”

Section: Cyanobacteria and Microalgae In Skin-ageingmentioning

confidence: 99%

“…These gram-negative bacteria represent the only group of prokaryotes that can perform oxygenic photosynthesis, similarly to plants, although with a higher photosynthetic rate and biomass production 20,21 . Their capacity to self-renew, basic nutritional requirements 22 , minimal cultivation space and low environmental impact 17,23 , makes them a sustainable choice for skin care products. Their residual biomass can be used as fertiliser or in animal feed, and can generate biopolyesters, known as "Green Plastics", thus fitting the concept of circular economy 17,24,25 .…”

Section: Introductionmentioning

confidence: 99%

Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Favas

Morone

Martíns

et al. 2021

Journal of Enzyme Inhibition and Medicinal Chemistry

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As the largest organ in human body, skin acts as a physicochemical barrier, offering protection against harmful environmental stressors, such as chemicals, pathogens, temperature and radiation. Nonetheless, skins prominence goes further, with a significant psychosocial role in an increasingly ageing population. Prompted by consumers' concern regarding skincare, cosmetic industry has been developing new formulas capable of lessening the most visible signs of ageing, including reduction in skin density and elasticity, wrinkling and hyperpigmentation. Allied to skincare is the rising importance set on natural products, sustainably obtained from less environmental impacting methods. Cyanobacteria and microalgae are adding importance in this field, given their ability to biosynthesize secondary metabolites with anti-ageing potential. In this review, we present an overview on the potential of cyanobacteria and microalgae compounds to overcome skin-ageing, essentially by exploring their effects on the metalloproteinases collagenase, elastase, gelatinase and hyaluronidase, and in other enzymes involved in the pigmentation process.

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“…a phycobiliprotein) that forms part of the photosynthetic light-harvesting phycobilisome (PBS) complex in most cyanobacteria and red algae. PC is considered a high-value product that is in significant demand from the food and cosmetics industries, as it is currently the only commercially available naturally-derived, soluble blue colourant ( Kupferschmidt, 2019 ; Nowruzi et al, 2020 ). PC is also a potent fluorophore with anti-oxidant properties, and thus is of interest to several other market sectors, including biopharmaceuticals, nutraceuticals, and research diagnostics ( Eriksen, 2008 ; Li et al, 2019 ; Pagels et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Production of thermostable phycocyanin in a mesophilic cyanobacterium

Puzorjov

Dunn

McCormick

2021

Metabolic Engineering Communications

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Phycocyanin (PC) is a soluble phycobiliprotein found within the light-harvesting phycobilisome complex of cyanobacteria and red algae, and is considered a high-value product due to its brilliant blue colour and fluorescent properties. However, commercially available PC has a relatively low temperature stability. Thermophilic species produce more thermostable variants of PC, but are challenging and energetically expensive to cultivate. Here, we show that the PC operon from the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1 ( cpcBACD ) is functional in the mesophile Synechocystis sp. PCC 6803. Expression of cpcBACD in an ‘Olive’ mutant strain of Synechocystis lacking endogenous PC resulted in high yields of thermostable PC (112 ± 1 mg g −1 DW) comparable to that of endogenous PC in wild-type cells. Heterologous PC also improved the growth of the Olive mutant, which was further supported by evidence of a functional interaction with the endogenous allophycocyanin core of the phycobilisome complex. The thermostability properties of the heterologous PC were comparable to those of PC from T. elongatus , and could be purified from the Olive mutant using a low-cost heat treatment method. Finally, we developed a scalable model to calculate the energetic benefits of producing PC from T. elongatus in Synechocystis cultures. Our model showed that the higher yields and lower cultivation temperatures of Synechocystis resulted in a 3.5-fold increase in energy efficiency compared to T. elongatus , indicating that producing thermostable PC in non-native hosts is a cost-effective strategy for scaling to commercial production.

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The cosmetic application of cyanobacterial secondary metabolites

Cited by 62 publications

References 141 publications

Bioactive Properties of Spirulina: A Review

Bioactive Properties of Spirulina: A Review

Cyanobacteria and microalgae bioactive compounds in skin-ageing: potential to restore extracellular matrix filling and overcome hyperpigmentation

Production of thermostable phycocyanin in a mesophilic cyanobacterium

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