The Cost-Effectiveness of Nicotine Replacement Therapy Sampling in Primary Care: a Markov Cohort Simulation Model

Chen, Brian; Silvestri, Gerard A.; Dahne, Jennifer; Lee, Kyueun; Carpenter, Matthew J.

doi:10.1007/s11606-021-07335-x

Cited by 10 publications

(7 citation statements)

References 73 publications

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“…To determine the similarity between sequences, we used OrthoMCL (Table S 6 ) clustering analysis to perform all-VS-All BLAST alignment on gene protein-coding sequences of all selected species (e-value = 1e-5 by default) [ 64 ]. Markov clustering algorithm was used for clustering analysis (expansion coefficient is 1.5), and the clustering results distinguished between the endemic and common genes, as depicted by the Venn diagram [ 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

High-quality chromosome-level de novo assembly of the Trifolium repens

Wang

et al. 2023

BMC Genomics

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Background White clover (Trifolium repens L.), an excellent perennial legume forage, is an allotetraploid native to southeastern Europe and southern Asia. It has high nutritional, ecological, genetic breeding, and medicinal values and exhibits excellent resistance to cold, drought, trample, and weed infestation. Thus, white clover is widely planted in Europe, America, and China; however, the lack of reference genome limits its breeding and cultivation. This study generated a white clover de novo genome assembly at the chromosomal level and annotated its components. Results The PacBio third-generation Hi-Fi assembly and sequencing methods generated a 1096 Mb genome size of T. repens, with contigs of N50 = 14 Mb, scaffolds of N50 = 65 Mb, and BUSCO value of 98.5%. The newly assembled genome has better continuity and integrity than the previously reported white clover reference genome; thus provides important resources for the molecular breeding and evolution of white clover and other forage. Additionally, we annotated 90,128 high-confidence gene models from the genome. White clover was closely related to Trifolium pratense and Trifolium medium but distantly related to Glycine max, Vigna radiata, Medicago truncatula, and Cicer arietinum. The expansion, contraction, and GO functional enrichment analysis of the gene families showed that T. repens gene families were associated with biological processes, molecular function, cellular components, and environmental resistance, which explained its excellent agronomic traits. Conclusions This study reports a high-quality de novo assembly of white clover genome obtained at the chromosomal level using PacBio Hi-Fi sequencing, a third-generation sequencing. The generated high-quality genome assembly of white clover provides a key basis for accelerating the research and molecular breeding of this important forage crop. The genome is also valuable for future studies on legume forage biology, evolution, and genome-wide mapping of quantitative trait loci associated with the relevant agronomic traits.

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Section: Discussionmentioning

confidence: 99%

High-quality chromosome-level de novo assembly of the Trifolium repens

Wang

et al. 2023

BMC Genomics

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“…The current trial was not focused on cost-effectiness outcomes, but a separate analysis of a prior trial of nicotine replacement therapy (NRT) sampling, using similar methods as those herein, demonstrated actual cost-savings. 35 Whether the same is true for e-cigarettes is unclear, but one might speculate that roughly comparable cost between NRT and e-cigarettes and superior outcomes (e-cigarettes > NRT), the same might hold.…”

Section: Discussionmentioning

confidence: 99%

Effect of unguided e-cigarette provision on uptake, use, and smoking cessation among adults who smoke in the USA: a naturalistic, randomised, controlled clinical trial

Carpenter¹,

Wahlquist²,

Dahne³

et al. 2023

eClinicalMedicine

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“…At present, there is not a clear path for paying for NRT samples through insurance United States reimbursement structures, although, if effective, NRTS may be cost‐saving for countries with socialized medicine. In primary care, NRTS cost $75 and was associated with a lifetime reduction of healthcare expenditures of $1065 34 . Evidence that NRTS is effective in oral healthcare could be used to advocate for policies to allow healthcare settings to provide point of care medication samples.…”

Section: Discussionmentioning

confidence: 99%

“…In primary care, NRTS cost $75 and was associated with a lifetime reduction of healthcare expenditures of $1065. 34 Evidence that NRTS is effective in oral healthcare could be used to advocate for policies to allow healthcare settings to provide point of care medication samples.…”

Section: Discussionmentioning

confidence: 99%

Dental staff and patient attitudes about nicotine replacement therapy samples in dental care: A National Dental Practice‐Based Research Network study

Japuntich,

Dunbar,

Predmore

et al. 2023

Comm Dent Oral Epid

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ObjectivesCigarette smoking negatively affects oral health. Nicotine replacement therapies (NRT; e.g. nicotine patch or lozenge) and brief interventions (e.g. Ask‐Advise‐Refer; AAR) can improve cessation outcomes but are underutilized. NRT sampling (NRTS) increases NRT utilization by providing patients with samples of NRT as part of routine healthcare. Ask‐Advise‐Refer is a brief intervention where practitioners: ask patients about tobacco use, advise those using tobacco to quit and refer to the state quit line. The objective of this qualitative study was to explore dental care practitioners' and patients' attitudes and experiences regarding tobacco cessation treatment and perceptions of two brief intervention models, assessed separately: NRTS and AAR.MethodsTwenty‐four dental care practitioners and nine patients, recruited through the National Dental Practice‐Based Research Network, participated in semi‐structured telephone interviews. Interviews assessed experiences with tobacco use intervention and attitudes towards NRTS and AAR. Thematic analysis identified emergent themes related to feasibility and acceptability of NRTS and AAR.ResultsPractitioners varied on how they address tobacco use, from systematically to idiosyncratically. Some practitioners recommend NRT; few had prescribed it. Practitioners had favourable attitudes towards AAR and NRTS, with most believing that both interventions would be acceptable and feasible to implement. Concerns regarding AAR were time and patient resistance to discussing tobacco use. Concerns regarding NRTS were patient resistance to using NRT, side effects or medication interactions, and capacity to provide follow‐up. Patients reported that oral health practitioners generally ask about tobacco use but do not provide interventions. Patients were open to discussing their tobacco use with practitioners and had favourable attitudes about NRTS.ConclusionsThis formative work suggests that NRTS and AAR may be feasible to implement in dental care settings. Future studies are needed to assess the effectiveness and implementation potential of NRTS in dental care settings.

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The Cost-Effectiveness of Nicotine Replacement Therapy Sampling in Primary Care: a Markov Cohort Simulation Model

Cited by 10 publications

References 73 publications

High-quality chromosome-level de novo assembly of the Trifolium repens

High-quality chromosome-level de novo assembly of the Trifolium repens

Effect of unguided e-cigarette provision on uptake, use, and smoking cessation among adults who smoke in the USA: a naturalistic, randomised, controlled clinical trial

Dental staff and patient attitudes about nicotine replacement therapy samples in dental care: A National Dental Practice‐Based Research Network study

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