The cost-effectiveness of the omeprazole test in noncardiac chest pain (NCCP)

Ofman, Joshua J.; Gralnek, IM; Udani, Jay; Fass, Robert J.

doi:10.1016/s0016-5085(98)80127-3

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…27 Schenk et al evaluated 85 NERD patients with the PPI test (omeprazole 40 mg daily) administered over a period of 14 days, and demonstrated a 66% sensitivity in this group of patients. 25 The PPI test consistently had a low specificity in GORD patients, specifically in NERD patients. A possible explanation for this phenomenon is the partial response to therapy by patients with functional heartburn, particularly those with a "sensitive oesophagus".…”

Section: Proton-pump Inhibitor Trial Of Therapymentioning

confidence: 93%

“…25,26 Patients with NERD demonstrated marked improvement in symptom response rate when the omeprazole test dose (given over seven days) was increased from 40 mg once daily to 40 mg twice daily. 27 Schenk et al evaluated 85 NERD patients with the PPI test (omeprazole 40 mg daily) administered over a period of 14 days, and demonstrated a 66% sensitivity in this group of patients.…”

Section: Proton-pump Inhibitor Trial Of Therapymentioning

confidence: 99%

See 1 more Smart Citation

Nonerosive reflux disease as a presentation of gastro-oesophageal reflux disease

Simmonds

2011

South African Family Practice

View full text Add to dashboard Cite

Section: Proton-pump Inhibitor Trial Of Therapymentioning

confidence: 93%

Section: Proton-pump Inhibitor Trial Of Therapymentioning

confidence: 99%

Nonerosive reflux disease as a presentation of gastro-oesophageal reflux disease

Simmonds

2011

South African Family Practice

View full text Add to dashboard Cite

“…82 These cost savings resulted from the reduced use of invasive diagnostic tests that are of unproven utility in the diagnosis and subsequent management of patients with NCCP. 83 If the PPI test is used initially and is inconclusive, then a pH test should be performed when the patient is off therapy.…”

Section: Proton Pump Inhibitor Testmentioning

confidence: 99%

Sensory Testing of the Esophagus

Fass

2004

Journal of Clinical Gastroenterology

View full text Add to dashboard Cite

Originally, sensory testing of the esophagus included the acid perfusion test and the edrophonium test, which were developed to assess patients with non-cardiac chest pain. In the last 2 decades interest in functional esophageal disorders has increased and thus further understanding of the underlying mechanisms of esophageal pain required development of new sensory testing techniques. Balloon distension using a computerized electronic device, electrical stimulation and impedance planimetry have generated important information about esophageal sensory thresholds for pain in different disease states. Intraluminal ultrasonography has been used to determine the physiologic changes of the muscle wall of the esophagus during perception of typical esophageal symptoms. Central evaluation of patients undergoing esophageal stimulation has recently been introduced to assess cerebral activation in different esophageal disorders. However, many studies using esophageal sensory testing are afflicted with significant design flaws, making interpretation of the results very difficult. This is primarily due to lack of recognition of factors that can modulate esophageal sensation.

show abstract

“…When decision analytic model utilizing Bayesian analysis was developed to compare the costs and outcomes of alternative diagnostic strategies for NCCP, noninvasive strategies utilizing the PPI empirical trial as the initial step resulted in significant cost savings as compared to invasive strategies [47]. These cost savings were a direct result of a significant reduction in the utilization of invasive diagnostic tests that are of unproven utility in the diagnosis and subsequent management of patients with NCCP [48].…”

Section: Costmentioning

confidence: 99%

Empirical Trials in Treatment of Gastroesophageal Reflux Disease

Fass¹

2000

Dig Dis

View full text Add to dashboard Cite

The assortment of diagnostic tests that are currently available for detecting gastroesophageal reflux disease (GERD) are invasive, costly and not readily available to community-based physicians. In contrast, a short course of high-dose proton pump inhibitor (PPI) as an empirical trial is an attractive alternative. This simple diagnostic test has been demonstrated to be accurate and cost-effective in patients with symptoms suggestive of GERD and those with noncardiac chest pain. Early studies in patients with extraesophageal manifestations of GERD have yielded promising results. Cost assessment of the PPI empirical trial revealed significant cost savings, mainly due to a marked decrease in utilization of invasive diagnostic tests. Thus the PPI empirical trial should be considered as the initial diagnostic step in patients with the disease spectrum of GERD.

show abstract

The cost-effectiveness of the omeprazole test in noncardiac chest pain (NCCP)

Cited by 4 publications

References 0 publications

Nonerosive reflux disease as a presentation of gastro-oesophageal reflux disease

Nonerosive reflux disease as a presentation of gastro-oesophageal reflux disease

Sensory Testing of the Esophagus

Empirical Trials in Treatment of Gastroesophageal Reflux Disease

Contact Info

Product

Resources

About