The current research determined the effect of toxic leadership on counter-productive work behaviors and the intention to leave work among a randomly selected sample of 357 employees of the Egyptian Pharmaceutical Trading Company using correlation analysis and regression analyses. There was a direct and significant effect of toxic leadership on each of the 5 dimensions of counter-productive work behaviors (abuse, production deviance, sabotage, theft, withdrawal), and the intention to leave work. Based on these results, employers should select leaders based on criteria that incorporate the psychological and humanitarian aspects of dealing with subordinates, furnish leaders with the relevant training and continuously track leaders’ behavior to ensure that stay clear of any toxic practices.