The Counterproductive Effect of Right Anodal/Left Cathodal Transcranial Direct Current Stimulation Over the Dorsolateral Prefrontal Cortex on Impulsivity in Methamphetamine Addicts

Jiang, Xiaoyu; Tian, Yu; Zhang, Zhiling; Zhou, Chen; Yuan, Jiajin

doi:10.3389/fpsyt.2022.915440

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Jiang et al applied tDCS and used two-choice oddball tasks to evaluate behavioral impulsivity prior to and after the treatment. However, they found that their protocol was not optimized to reduce symptoms associated with METH addiction (42). Khajehpour et al conducted a sham-controlled tDCS stimulation experiment with 42 male participants with METH addiction (112).…”

Section: Tdcs For Methamphetamine Addictionmentioning

confidence: 99%

“…Therefore, non-invasive types are preferred owing to their wearability and accessibility. Commonly employed non-invasive neuromodulations for METH addiction include transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) (41,42). tDCS changes the excitation states of neurons using low-dose direct currents (43).…”

Section: Introductionmentioning

confidence: 99%

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Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Chen

Yang

et al. 2023

Front. Psychiatry

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Achieving abstinence from drugs is a long journey and can be particularly challenging in the case of methamphetamine, which has a higher relapse rate than other drugs. Therefore, real-time monitoring of patients’ physiological conditions before and when cravings arise to reduce the chance of relapse might help to improve clinical outcomes. Conventional treatments, such as behavior therapy and peer support, often cannot provide timely intervention, reducing the efficiency of these therapies. To more effectively treat methamphetamine addiction in real-time, we propose an intelligent closed-loop transcranial magnetic stimulation (TMS) neuromodulation system based on multimodal electroencephalogram–functional near-infrared spectroscopy (EEG-fNIRS) measurements. This review summarizes the essential modules required for a wearable system to treat addiction efficiently. First, the advantages of neuroimaging over conventional techniques such as analysis of sweat, saliva, or urine for addiction detection are discussed. The knowledge to implement wearable, compact, and user-friendly closed-loop systems with EEG and fNIRS are reviewed. The features of EEG and fNIRS signals in patients with methamphetamine use disorder are summarized. EEG biomarkers are categorized into frequency and time domain and topography-related parameters, whereas for fNIRS, hemoglobin concentration variation and functional connectivity of cortices are described. Following this, the applications of two commonly used neuromodulation technologies, transcranial direct current stimulation and TMS, in patients with methamphetamine use disorder are introduced. The challenges of implementing intelligent closed-loop TMS modulation based on multimodal EEG-fNIRS are summarized, followed by a discussion of potential research directions and the promising future of this approach, including potential applications to other substance use disorders.

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Section: Tdcs For Methamphetamine Addictionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Chen

Yang

et al. 2023

Front. Psychiatry

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Effects of fear of missing out on inhibitory control in social media context: evidence from event-related potentials

Xu,

Tian

2023

Front. Psychiatry

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The present study aimed to investigate the impact of fear of missing out (FoMO) on inhibitory control in social media context. The present study used a two-choice oddball task combined with event-related potentials (ERPs) technology to measure inhibitory control. Based on the Fear of Missing Out Scale, participants with varying degrees of FoMO were recruited to complete two studies. A total of 78 participants in Study 1 completed a two-choice oddball task (stimuli “W” or “M”). The results showed that FoMO did not have a significant impact on general inhibitory control at both the behavioral and electrophysiological levels. To further examine the effect of FoMO in social media context. In Study 2, 72 participants completed a modified two-choice oddball task with three types of pictures (high and low social media-related and neutral). The behavioral results revealed that as FoMO scores increased, inhibitory control decreased. ERP analysis revealed that with higher FoMO scores, social media-related pictures elicited larger N2 amplitude and smaller P3 amplitude, but not for neutral pictures. This suggests that FoMO undermines inhibitory control by consuming more cognitive resources in the early conflict detection stage and leading to insufficient cognitive resources in the later stages of the inhibitory process. These findings suggest that FoMO can undermine inhibitory control in the social media context. Considering the indispensable use of social media in the digital age, addressing and understanding the influence of FoMO on inhibitory control could be essential for promoting healthy digital behaviors and cognitive functions.

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Effectiveness of Transcranial-Direct Current Stimulation in Individuals with Methamphetamine Use Disorder: A Systematic Review and Meta-Analysis

Sahaf,

Heydari Yazdi,

Ramezani

et al. 2024

Int J High Risk Behav Addict

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Context: Non-alcoholic substance abuse is a major public health concern worldwide, with methamphetamine being the second most widely used non-alcoholic substance globally, and Iran ranks fifth in methamphetamine addiction. To date, no approved pharmacological or non-pharmacological treatment by the Food and Drug Administration has been introduced for methamphetamine use disorder (MUD). Therefore, various treatment methods are currently utilized. One non-pharmacological approach that has gained attention is transcranial-direct current stimulation (tDCS), with various clinical evaluations focused on it. Objectives: The aim of this review is to assess the effectiveness of this method in improving symptoms in individuals with MUD. Methods: Databases were reviewed up to October 10, 2023, in both Persian and English languages, using PubMed, Scopus, Web of Science, Google Scholar, Science Direct, Scientific Information Database (SID), and Noormags. Keywords were MUD, tDCS, Addiction, Craving, and Cognitive Function. Studies were included based on Population, Intervention, Comparison (sham or active control), Outcomes (craving or cognition), and Study Design (randomized controlled trial). Studies were excluded if they involved brain mapping or neuroimaging. Meta-analysis was conducted based on Standardized Mean Difference (SMD) to compare tDCS to sham intervention (P ≤ 0.05, two-tailed). Random effects models were used for individual MUD data from studies that reported end-of-treatment craving data. The risk of bias was calculated using the Cochrane Risk-of-Bias Tool (RoB-2), and meta-analysis was conducted using Comprehensive Meta-Analysis Software. Results: A total of 870 studies were initially identified; twenty-three studies (mean age 30.13 ± 6.67) were identified that examined the effects of tDCS on MUD outcomes (e.g., craving, cognition). After removing heterogeneous studies, meta-analyses were performed for tDCS vs. sham control studies in the craving domain. We found that tDCS reduced craving, indicated by medium to large effect sizes (Hedges' g: -0.64; SMD -0.58, 95% CI -0.85 to -0.30; I² = 10.71%, Q value: 8.96). Results showed that complementary treatment with tDCS can be useful. The DLPFC (F3, F4) was the most commonly targeted brain region for stimulation or inhibition. However, the number of sessions and their duration varied significantly across studies. Conclusions: This systematic review and meta-analysis found that tDCS can reduce momentary and cue-induced cravings. However, the studies varied in quality and sample size and used different scales for assessing cravings and cognitive functions, leading to inconsistencies. The review highlighted the importance of targeting the DLPFC due to its role in executive functions and self-control, with right-sided stimulation showing greater effectiveness. Emotional dysregulation in MUD, such as anxiety and depression, was also noted, with tDCS showing limited support for emotion regulation. The review identified the need for larger RCTs, standardized measurement tools, and detailed participant information to improve the understanding and effectiveness of tDCS in treating MUD.

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The Counterproductive Effect of Right Anodal/Left Cathodal Transcranial Direct Current Stimulation Over the Dorsolateral Prefrontal Cortex on Impulsivity in Methamphetamine Addicts

Cited by 3 publications

References 41 publications

Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Challenges and future trends in wearable closed-loop neuromodulation to efficiently treat methamphetamine addiction

Effects of fear of missing out on inhibitory control in social media context: evidence from event-related potentials

Effectiveness of Transcranial-Direct Current Stimulation in Individuals with Methamphetamine Use Disorder: A Systematic Review and Meta-Analysis

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