“…The interepisode period is also important because individuals suffer from other significant symptomatology and impairment (e.g., Harrow, Goldberg, Grossman, & Meltzer, 1990; MacQueen et al, 2003), including mood dysregulation. For example, there is preliminary evidence that interepisode bipolar patients exhibit affective lability and increased reactivity (Fukuda, Etoh, Iwadate, & Ishii, 1983; Tsuang, Woolson, & Fleming, 1979), particularly with regard to positive affect (for review see Gruber, in press; Johnson, 2005). The evidence is mixed regarding interepisode patients' negative effect.…”