The course of high‐sensitive C‐reactive protein in correlation with pain and clinical function in patients with acute lumbosciatic pain and chronic low back pain—A 6 months prospective longitudinal study

Gebhardt, Katja; Brenner, Hermann; Stürmer, Til; Raum, Elke; Richter, Wiltrud; Schiltenwolf, Marcus; Buchner, Matthias

doi:10.1016/j.ejpain.2005.11.005

Cited by 55 publications

(70 citation statements)

References 47 publications

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“…We also demonstrated a similar trend among our cohort of patients with back pain. Stümer et al [23] and Gebhardt et al [24] observed a strong association between pain severity and CRP levels in patients with sciatic pain but not in those with chronic LBP. CRP-an acute phase reactant is an indicator of low grade inflammation.…”

Section: Discussionmentioning

confidence: 98%

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

et al. 2014

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Low back pain is very disabling and dispiriting because of the physical impediment it causes and its psychological effects. Innumerable factors have been implicated in its etiology. In spite of improvements in diagnostic modalities, a considerable number of such cases fall in the ambiguous zone of unknown etiology or 'idiopathic.'Early diagnosis of low back pain will allow effective prevention and treatment to be offered. This study was conducted to assess the contribution of vitamin D levels and other biochemical factors to chronic low back pain in such cases. All patients attending the orthopedics OPD for low back pain in whom a precise anatomical cause could not be localized, were prospectively enrolled in this study. We measured serum levels of glucose, calcium, phosphorus, uric acid, rheumatoid factor, C reactive protein, alkaline phosphatase, total protein, albumin and 25 (OH) D concentrations in 200 cases and 200 control samples. The patients showed significantly lower vitamin D levels compared to controls with p value \ 0.0001. The maximum number of low back pain patients were in the age group of 31-50 years (42 %).The average BMI was 23.27 ± 5.17 kg/sq m, 73 % of total patient population were females and 27 % were known case of type 2 diabetes mellitus. Calcium, alkaline phosphatase, was positively correlated with vitamin D and glucose showed a negative correlation with vitamin D in the patient population. The problem of low back pain provides a challenge to health care providers. The problem in developing countries is compounded by ignorance to report for early treatment and occupational compulsions in rural areas and sedentary lifestyle in urban youth. The authors strongly recommend early frequent screening for vitamin D along with glucose, protein, albumin, calcium, phosphorus, CRP as part of general health checkup for non-specific body pain, especially low back pain.

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Section: Discussionmentioning

confidence: 98%

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

et al. 2014

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“…One study found no difference in serum hs-CRP level between patients with acute disc herniation-induced lumbosciatic pain and healthy controls [9]. In the other two studies [26,45], serum hs-CRP level was higher in patients with lumbosciatic syndrome or herniated lumbar disc than in controls.…”

Section: Physical Exercise and Sportsmentioning

confidence: 96%

“…Three case-control studies [9,26,45] addressed the association between high-sensitive C-reactive protein (hs-CRP) and clinically defined sciatica (Table 5). One study found no difference in serum hs-CRP level between patients with acute disc herniation-induced lumbosciatic pain and healthy controls [9].…”

Section: Physical Exercise and Sportsmentioning

confidence: 99%

Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: a systematic review

et al. 2007

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Lumbar radicular pain is a fairly common health problem, yet its risk factors are far from clear. There are no published systematic reviews on associations between cardiovascular or lifestyle risk factors and lumbar radicular pain or sciatica. The aim of this systematic literature review was to assess associations between these risk factors and lumbar radicular pain or sciatica. We conducted a systematic search of the Medline database for all original articles on lumbar radicular pain or sciatica published until August 2006. Twenty-two papers from 19 studies were included in the review. Overweight or obesity was associated with sciatica in most of the casecontrol and cohort studies. Some studies showed an increased risk of lumbar radicular pain in smokers with a long smoking history or in those with high levels of physical activity. A few case-control studies showed an association between serum C-reactive protein and sciatica. No consistent associations were found for serum lipids levels or high blood pressure. In summary, the associations of overweight, long smoking history, high physical activity and a high serum C-reactive protein level with lumbar radicular pain or sciatica were substantiated by the present review. However, more prospective studies are needed in order to further clarify these associations and the mechanisms of action.

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“…Just one study, Karppinen et al [29], included BMI and work load in the analyzes. Moreover, Gebhardt et al [37] controlled for smoking and BMI. In only 6 studies the data were evaluated after correction for their multiple testing.…”

Section: Resultsmentioning

confidence: 99%

Genes associated with persistent lumbar radicular pain; a systematic review

Bjorland

Møen

Schistad

et al. 2016

BMC Musculoskelet Disord

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BackgroundThe aim of the present study was to provide an overview of the literature addressing the role of genetic factors and biomarkers predicting pain recovery in newly diagnosed lumbar radicular pain (LRP) patients.MethodsThe search was performed in Medline OVID, Embase, PsycInfo and Web of Science (2004 to 2015). Only prospective studies of patients with LRP addressing the role of genetic factors (genetic susceptibility) and pain biomarkers (proteins in serum) were included. Two independent reviewers extracted the data and assessed methodological quality.ResultsThe search identified 880 citations of which 15 fulfilled the inclusion criteria. Five genetic variants; i.e., OPRM1 rs1799971 G allele, COMT rs4680 G allele, MMP1 rs1799750 2G allele, IL1α rs1800587 T allele, IL1RN rs2234677 A allele, were associated with reduced recovery of LRP. Three biomarkers; i.e., TNFα, IL6 and IFNα, were associated with persistent LRP.ConclusionThe present results indicate that several genetic factors and biomarkers may predict slow recovery in LRP. Still, there is a need for replication of the findings. A stricter use of nomenclature is also highly necessary.Trial registrationThe review is registered PROSPERO 20th of November 2015. Registration number is CRD42015029125.

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The course of high‐sensitive C‐reactive protein in correlation with pain and clinical function in patients with acute lumbosciatic pain and chronic low back pain—A 6 months prospective longitudinal study

Cited by 55 publications

References 47 publications

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

Assessment of Vitamin D status In Patients of Chronic Low Back Pain of Unknown Etiology

Cardiovascular and lifestyle risk factors in lumbar radicular pain or clinically defined sciatica: a systematic review

Genes associated with persistent lumbar radicular pain; a systematic review

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