The Course of Neurocognition and Social Functioning in Individuals at Ultra High Risk for Psychosis

Niendam, Tara A.; Bearden, Carrie E.; Zinberg, Jamie; Johnson, J. Kristie; O’Brien, Mary P.; Cannon, Tyrone D.

doi:10.1093/schbul/sbm020

Cited by 142 publications

(121 citation statements)

References 56 publications

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“…In fact, impaired speed of processing has been found not only in patients with schizophrenia, but also in subjects at high risk for developing psychosis 62,63 , in patients with first-episode schizophrenia spectrum disorders 64 , and in healthy relatives of schizophrenia patients 65,66 . The relationship between speed of processing and functioning found in the present study has also been described by other authors.…”

Section: Discussionmentioning

confidence: 99%

Neurocognition, social cognition and functional outcome in schizophrenia

et al. 2014

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SPAINABSTRACT -Background and Objectives: A relationship has been found between cognition and functioning in patients with schizophrenia. Our objective was to study the relationship between the cognitive domains assessed by the MATRICS Consensus Cognitive Battery (MCCB), and functioning as evaluated using the functioning subscale of the Global Assessment of Functioning scale (GAF-f).Methods: A sample of 83 clinically stable outpatients diagnosed with schizophrenia according to DSM-IV criteria were assessed using the MCCB and the GAF-f. Pearson correlations and stepwise linear regression analyses were performed.Results: Correlation analysis between the GAF-f and the cognitive domains of the MCCB showed a significant relationship between functioning and all of the cognitive domains. Regression yielded a statistically significant model (F 2,74 = 20.4, p < 0.001) in which functioning was related to Speed of processing (standardized β = 0.369, p = 0.001) and to Social cognition (standardized β = 0.325, p = 0.003). Together, these two variables explained 33.8% of the variance of functioning.Conclusions: Both speed of processing and social cognition have an important association with functioning in patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Neurocognition, social cognition and functional outcome in schizophrenia

et al. 2014

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“…Interestingly, the majority of studies do not support a difference in visual memory (Niendam et al 2006(Niendam et al , 2007Pukrop et al 2006;Becker et al 2010b;Lindgren et al 2010). Both verbal and visuo-spatial workingmemory deficits have frequently been reported in the CHR population (Brewer et al 2006); however, recent results are inconsistent with four to five studies demonstrating working-memory deficits and the same number reporting no differences.…”

Section: Comparison Of Chr Individuals With Healthy Controlsmentioning

confidence: 99%

The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis

Addington

Barbato

2012

Epidemiol Psychiatr Sci

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Although it is well established that cognitive impairment is a common feature of schizophrenia, only recently has cognitive functioning been prospectively studied in individuals at clinical high risk (CHR) for developing psychosis. To date, both cross-sectional and longitudinal studies have been conducted in the CHR population and in the context of later conversion to psychosis. A comprehensive review of the literature suggests that CHR individuals have general and specific baseline cognitive deficits compared to healthy controls. As a group, their cognitive course, tends to remain stable over time and in this way does not differ from healthy controls. For those who go on to develop a full-blown psychotic illness compared to those who do not convert, there appeared to be minimal differences at baseline with respect to cognition, although over time the converters may show deterioration in certain cognitive abilities compared to the non-converters. However, for many cognitive domains results are mixed, and may result from methodological limitations.

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“…Neurocognitive impairments are well documented in patients with schizophrenia [47][48][49] . They have been described in early stages of the disease [50,51] , in the prodromic phases [52,53] and in unaffected relatives [54,55] . They have been considered the 'rate limiting factor' for social recovery [56][57][58] .…”

Section: Cognitivismmentioning

confidence: 99%

What Is It like to Be a Person with Schizophrenia in the Social World? A First-Person Perspective Study on Schizophrenic Dissociality – Part 1: State of the Art

Stanghellini

Ballerini

2011

Psychopathology

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This is a critical review of research on the subjective experience of social dysfunction in persons with schizophrenia. Studies from the phenomenological and cognitive paradigms are examined, and significant outcomes and shortcomings are pointed out. Clinical phenomenologists have mainly interpreted schizophrenic dissociality as an anomaly of prereflexive attunement. The main shortcoming of phenomenological research is that it lacks adequate methodology to collect reliable data since most studies are based on the analysis of a few typical cases. Cognitivism has reliably documented disorders of social functioning in large-scale experimental studies. The main shortcoming of most cognitive paradigms is that they do not properly investigate the personal level of experience in real-world functioning. We conclude that there is a need to reliably collect data through quantitative as well as qualitative methodology as established and accepted by the scientific community in the area of schizophrenic dissociality, reflecting the subjective experiences of people with schizophrenia in the real world.

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The Course of Neurocognition and Social Functioning in Individuals at Ultra High Risk for Psychosis

Abstract: Although the degree of neurocognitive deficit at baseline in UHR patients does not predict psychosocial outcome, the course of neurocognitive change over the first 8 months of follow-up does differentiate patients with good and poor functional outcomes.

Cited by 142 publications

References 56 publications

Neurocognition, social cognition and functional outcome in schizophrenia

Neurocognition, social cognition and functional outcome in schizophrenia

The role of cognitive functioning in the outcome of those at clinical high risk for developing psychosis

What Is It like to Be a Person with Schizophrenia in the Social World? A First-Person Perspective Study on Schizophrenic Dissociality – Part 1: State of the Art

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