The course of spinocerebellar fibers in the spinal cord and lower medulla in the rat. Study with the method of retrograde axonal transport.

Shirao, Kuniaki

doi:10.1272/jnms1923.54.301

Cited by 2 publications

(3 citation statements)

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“…Our results on the locations of spinocerebellar axons in the spinal cord of the opossum appear to be comparable to those reported in the rat (Shirao, 1987;Yamada et al, 1991), the cat (Grant, 1962;Xu and Grant, 1994), the dog (Sherrington and Laslett, 1903;Horax, 1915), the macaque monkey (Yoss, 1952(Yoss, , 1953, and man (Smith, 1957). We are convinced that the axons labeled in our studies were spinocerebellar axons.…”

Section: Discussionsupporting

confidence: 90%

“…Axons originating in lamina VII project ipsilaterally into the VLF, and axons of the NCB project ipsilaterally into the dorsal part of the lateral funiculus (Xu and Grant, 1994). Contemporary tract-tracing and electrophysiological methods have shown that additional spinocerebellar axons are present in the dorsal part of the lateral funiculus and in the VLF that are not considered to be part of the three pathways described above (see, e.g., Shirao, 1987;Grottel et al, 1991;Yamada et al, 1991;Huber et al, 1994;Xu and Grant, 1994). For example, axons from contralaterally projecting neurons of the sacral and coccygeal cord (e.g., SN and VLN) are present in the dorsal part of the lateral funiculus, and axons of the CCN are present in the VLF.…”

Section: Discussionmentioning

confidence: 99%

“…In the opossum, spinocerebellar axons in the dorsal part of the lateral funiculus are found along the ventrolateral border of the dorsal horn only at midthoracic levels, whereas, in the cat, they abut the dorsal horn at all thoracic and cervical levels (Xu and Grant, 1994). In the rat, they do not approximate the dorsal horn at all (Shirao, 1987;Yamada et al, 1991). In the opossum (present study) and the rat (Shirao, 1987;Yamada et al, 1991), spinocerebellar axons are situated in the dorsal part of the lateral funiculus at sacral levels, but they are not found in that area at the same levels in the cat (Xu and Grant, 1994).…”

Section: Discussionmentioning

confidence: 99%

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Origin, course, and laterality of spinocerebellar axons in the North American Opossum,Didelphis virginiana

1998

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Spinocerebellar axons have been studied extensively in placental mammals, but there have been no full reports on their origin, laterality, or spinal course in any marsupial. We have used the North American opossum (Didelphis virginiana) to obtain such information and to ask whether any spinocerebellar neurons innervate both the anterior and posterior lobes of the cerebellum through axonal collaterals. To identify spinal neurons that project to the cerebellum, we employed the retrograde transport of Fluoro-Gold (FG) from the anterior lobe, the main target of spinocerebellar axons. In some cases, cerebellar injections of FG were combined with hemisections of the rostral cervical or midthoracic spinal cord, so that laterality of spinocerebellar connections could be established. To determine whether single neurons project to both the anterior lobe and the posterior lobe, injections of Fast Blue (FB) into the anterior lobe were combined with injections of Diamidino yellow (DY) or rhodamine B dextran (RBD) into the posterior lobe, or vice versa. Following injections of FG into the anterior lobe, neurons were labeled throughout the length of the spinal cord, which differed in laminar distribution and laterality of their projections. Among other areas, neurons were labeled in the central cervical nucleus, the nucleus centrobasalis, Clarke's nucleus, the dorsal horn dorsal spinocerebellar tract area, the spinal border region, and Stilling's nucleus. When anterior lobe injections of FB were combined with injections of RBD or DY into the posterior lobe, or vice versa, some double-labeled neurons were present in all major spinocerebellar groups. Cerebellar injections of FG also retrogradely labeled spinocerebellar axons, allowing us to document their locations in the gray matter as well as within the periphery of the lateral and ventral funiculi at all spinal levels. A few spinocerebellar axons also were found in the dorsal funiculus (a dorsal column-spinocerebellar tract), which appeared to originate from neurons in the dorsal part of Clarke's nucleus from the ninth thoracic segment to the first lumbar segment. Our results indicate that spinocerebellar axons in the marsupial opossum are generally comparable in origin, course, and laterality to the same axons in the placental mammals studied to date.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Origin, course, and laterality of spinocerebellar axons in the North American Opossum,Didelphis virginiana

1998

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Trajectory of spinocerebellar fibers passing through the inferior and superior cerebellar peduncles in the rat spinal cord: A study using horseradish peroxidase with pedunculotomy

Yamada

Shirao

Kitamura

et al. 1991

J of Comparative Neurology

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The course of spinocerebellar fibers in the rat spinal cord was investigated by injecting horseradish peroxidase into the cerebellar anterior vermis after complete transection of the left inferior and right superior cerebellar peduncles. By this procedure, fibers passing via the inferior cerebellar peduncles (icp-fibers) were labeled retrogradely on the right side of the spinal cord, whereas fibers passing via the superior cerebellar peduncles (scp-fibers) were labeled on the left side. Crossed icp-fibers were located diffusely in the anterior and lateral funiculi in the sacral to lower lumbar segments. They gradually migrated laterally and dorsally in these funiculi and received many uncrossed icp-fibers moving laterally in the lateral funiculus from the gray substance in the upper lumbar to lower thoracic segments. These mixed fibers shifted more dorsally and laterally in the anterior and lateral funiculi to aggregate in the narrow peripheral zone of the lateral funiculus in the upper thoracic and lower cervical segments, and received many crossed fibers in the upper cervical segments. There were more icp-fibers than scp-fibers through the spinal cord. However, the extent of scp-fibers in the anterior and lateral funiculi was essentially the same as that for icp-fibers, except that a few scp-fibers were found in the dorsolateral marginal zone of the lateral funiculus. It has been generally accepted that the dorsal spinocerebellar tract ascends in the dorsal half of the lateral funiculus and enters the cerebellum via the inferior cerebellar peduncle, whereas the ventral spinocerebellar tract ascends in the ventral half of it and takes the superior cerebellar peduncle route. The results of this study suggest that it is necessary to revise this concept.

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The course of spinocerebellar fibers in the spinal cord and lower medulla in the rat. Study with the method of retrograde axonal transport.

Cited by 2 publications

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Origin, course, and laterality of spinocerebellar axons in the North American Opossum,Didelphis virginiana

Origin, course, and laterality of spinocerebellar axons in the North American Opossum,Didelphis virginiana

Trajectory of spinocerebellar fibers passing through the inferior and superior cerebellar peduncles in the rat spinal cord: A study using horseradish peroxidase with pedunculotomy

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