The COVID-19 pandemic: a systematic review of the current evidence

Ghomi, Robabeh; Asgari, Nasrin; Hajiheydari, A.; Esteki, Razieh; Biyabanaki, Fereshte; Nasirinasab, Fahime

doi:10.15789/2220-7619-tcp-1508

Cited by 9 publications

(3 citation statements)

References 73 publications

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“…Новая коронавирусная инфекция COVID-19, возникшая в декабре 2019 г. в Китае, стремительно распространилась по всему миру, и в марте 2020 г. Всемирной организацией здравоохранения было объявлено о начале пандемии [5,11].…”

Section: Introductionunclassified

Features of the new coronavirus COVID-19 infection in identical twins

Yudina

Киселева

Rusanova

et al. 2022

Russian Journal of Infection and Immunity

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The problem of the clinical course and principles of treatment of the new coronovirus infection Covid-19 has been the most discussed for two years. The disease can occur as an asymptomatic carriage, latent course, and severe forms with damage to the lungs, cardiovascular, circulatory and nervous systems, urogenital and gastrointestinal tracts. Numerous studies of Covid-19 have made it possible to study in detail the pathogenesis and apply effective methods of treatment using monoclonal antibodies to cytokines and their receptors, Janus-kinase inhibitors, convalescent plasma, etc. At the same time, reliable prognostic criteria that determine the characteristics of the course and the outcome of the disease has not been established. The features of the clinical course of a new coronavirus infection in patients with rare comorbid pathology (genetic diseases, a history of organ and tissue transplantation, paraneoplastic processes) are also of scientific and practical interest. With this in mind, the article presents clinical cases of a new coronavirus infection Covid-19 in identical twins.Patients A. and С., 39 years old, were admitted to the Regional Clinical Infectious Diseases Hospital with complaints of fever up to 37.5-37.80C, dry cough, shortness of breath at rest, weakness. Both patients fell ill at the same time, on the fourth day after contact with their father, who was diagnosed with Covid-19 coronavirus infection, confirmed by a PCR test. Upon admission, the patients were clinically diagnosed with Covid-19 coronavirus infection, a confirmed moderate form. Bilateral polysegmental pneumonia of moderate severity. Respiratory failure I degree.Despite the same history data, the course of Covid-19 coronavirus infection in identical twins was significantly different. Patient A. had lymphocytosis up to 46% in the blood, ESR acceleration up to 12 mm/h, CRP increase up to 5 mg/ml, ferritin up to 333 ng/ml, interleukin-6 up to 7.5 pg/ml, D-dimer up to 560 ng/ml. Unlike patient A., his twin brother (patient C.) had lymphopenia up to 16%, accelerated ESR up to 20 mm/h, a significant increase in CRP up to 10 mg/mg, interleukin-6 up to 9.5 pg/ml , D-dimer - up to 750 ng/ml Patient A.'s condition remained stable. Against the background of the ongoing treatment, already on the fourth day of treatment, a pronounced positive trend was noted, on the 13th day of treatment, the patient was discharged from the hospital in a satisfactory condition under the supervision of a doctor at the place of residence.The condition of the patient С. on the 3rd day of hospitalization deteriorated sharply. Considering the decrease in SpO2 level to 88%, the lesion of the lung parenchyma is more than 70%, the council of doctors decided to conduct non-invasive oxygen therapy, the patient, in addition to the treatment, was prescribed antibacterial drugs, a drug of monoclonal antibodies to interleukin-6 and a selective reversible an inhibitor of Janus-kinases 1 and 2. On the 16th day of treatment, a CT scan of the chest organs was performed in dynamics, where a decrease in lung damage was noted, and a positive trend was also noted in laboratory parameters. Subjectively, the patient showed an improvement in well-being. During the next two days, the patient's condition with pronounced positive dynamics on the 19th day of hospital stay, the patient was discharged for rehabilitation at the place of residence.Thus, significant differences in the severity of the course of a new coronavirus infection in identical twins with the same history, the absence of aggravating comorbid conditions, are most likely due to the initial dose of the viral load, which was an important factor determining the development and course of infection.

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Section: Introductionunclassified

Features of the new coronavirus COVID-19 infection in identical twins

Yudina

Киселева

Rusanova

et al. 2022

Russian Journal of Infection and Immunity

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“…Начало этой ситуации свя зывают с несколькими случаями атипичных пнев моний в городе Ухань провинции Хубей Китайской Народной Республики, зарегистрированными в конце 2019 г. Однако уже через полгода вирус SARSCoV2 распространился практически по все му миру, неся с собой серьезные экономические и социальные последствия. По официальным дан ным, на 01.01.2022 г. зарегистрировано уже более 280 млн случаев инфицирования новой корона вирусной инфекцией и более 5 млн летальных ис ходов [1][2][3][4][5].…”

Section: Introductionunclassified

COVID-19 Outbreak at Sports Club: Conditions of Occurrence and Causes of the Spread of Infection

Голубкова

Platonova

Smirnova

et al. 2022

Epidemiology and Vaccinal Prevention

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Relevance. The new coronavirus infection (COVID-19), which appeared in late 2019 in China, has spread to almost all countries of the world in just a few months. The explosive nature of its spread was accompanied by the formation of large epidemic foci in organizations of various profiles, including leisure and sports. Aims. To establish the conditions and causes of the spread of SARS-CoV-2 among the members of one of the sports clubs based on an in-depth epidemiological analysis. Materials and methods. To study the features of the spread of the SARS-CoV-2 virus in a sports organization, the following documents were used previously developed by the authors and successfully tested in practice: «Act of epidemiological investigation of group and outbreak morbidity of new coronavirus infection (COVID-19) at an enterprise/organization/institution» and «Individual card of a patient with a new coronavirus infection (COVID-19) at the enterprise / organization/institution». In the process of epidemiological investigation, in order to detect SARS-CoV-2 RNA in PCR, a laboratory examination of sports club participants (sick and contact) was conducted, followed by genome-wide sequencing of isolated SARS-CoV-2 viruses on the basis of the Laboratory of Molecular Virology of the A. A. Smorodintsev Influenza Research Institute, which performs these types of studies. Results. Within 17 days, 26 cases of COVID- 19 were registered among the sports team members and staff from the support group (coaching staff, medical staff, administrators), which was 74.3% of their actual number. The majority of patients (76.9%) had mild acute respiratory infection, two (7.7%) had no symptoms, and four (15.4%) had interstitial pneumonia. Of the clinical manifestations of the disease, the most frequent were weakness, fever, headache, muscle and joint pain, difficulty in nasal breathing and serous-mucous discharge from the nose, sore throat, cough, shortness of breath, anosmia and dyspeptic manifestations in the form of diarrhea, nausea or vomiting. The occurrence of the outbreak was the result of the introduction of infection from the opposing team at the tournament. The leading factors that contributed to the spread of COVID-19 among sports club members were the admission to games and training of athletes with acute respiratory infections, prolonged close contact between players during training and competitions, violations in the use of personal protective equipment, compliance with hygiene and hand antiseptics, disinfection measures in the premises of sports institutions and defects in the implementation of the regulations for the examination of teams for SARS-CoV-2 during tournaments. Conclusion. Based on the results of the study, data were obtained on the features of the spread of SARS-CoV-2 in sports organizations, which can be used in conducting preventive and anti-epidemic measures in sports and leisure institutions.

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“…The problem of early differential diagnosis and prescription of personalized treatment for COVID-19 has not lost its relevance even two years after the onset of the pandemic; moreover, it is becoming increasingly important [ 1 ]. Compared to many other groups of diseases that have been studied for a long time and have a large evidence base, therapies for COVID-19 are in the process of formation [ 2 ]. New strains are emerging, knowledge about which is still insufficient, and treatment regimens are often changed due to their imperfection (from March 2020 to December 2021, 13 versions of clinical recommendations were issued in Russia).…”

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An Intelligent System for Medical Decision Support in Differential Diagnosis and Treatment of COVID-19

Грибова

Kulchin

Petryaeva

et al. 2022

Her. Russ. Acad. Sci.

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The development of electronic services to help doctors in the diagnosis and treatment of COVID-19 is discussed. The existing systems for such purposes are analyzed, and requirements for them are formulated. The architecture of an intelligent medical decision support system and the basic principles of its development using an ontology-oriented approach are given. The unique capabilities of the system are shown, and its information and software components are described.

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The COVID-19 pandemic: a systematic review of the current evidence

Cited by 9 publications

References 73 publications

Features of the new coronavirus COVID-19 infection in identical twins

Features of the new coronavirus COVID-19 infection in identical twins

COVID-19 Outbreak at Sports Club: Conditions of Occurrence and Causes of the Spread of Infection

An Intelligent System for Medical Decision Support in Differential Diagnosis and Treatment of COVID-19

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