Background The number of cases of coronavirus disease-19 (COVID-19) is still increasing especially in South Asia. There is an urgent need to measure the knowledge of the disease among health science students who may be required to play an active role in pandemic control. The research was conducted to answer how does Nepalese medical students' knowledge about coronavirus compare to medical students in other countries and what are the educational needs of medical students who may be called in to support the treatment of COVID-19 in Nepal. Methods A cross sectional study was performed during the third week of June among first to final year medical and dental students. As the country was in lockdown, a structured online questionnaire was used to obtain data. The responses obtained were cleaned, coded, entered in IBM SPSS Statistics for Windows and the normality of the data checked using one-sample Kolmogorov Smirnov test (p<0.05). The demographic parameters were tabulated and total score compared among different subgroups of participants. The frequency of different measures mentioned by respondents to control the pandemic were also noted. Results Out of the 565 participants, 336 (59.6%) were females followed by 229 (40.4%) males. Nearly half of the participants, 282 (49.8%) were belonging to age group 21-23 years. Majority 415 (73.5%) were undergraduate medical and 150 (26.5%) were undergraduate dental students. The largest number of respondents, 140 (24.9%) were from second year of study and 344 (60.9%) were from urban areas. The median total score was 21 and the interquartile range 4. The maximum possible score was 30. The scores among students belonging to different years of study were significantly different (p=0.033). Total scores were not significantly different among other subgroups of respondents. Conclusions The knowledge of the participants was good. Deficiencies in knowledge were noted in certain areas and these should be addressed through an educational intervention. In countries where epidemic is on the rise, strategies to keep health science students updated with proper information related to COVID-19 is important. Similar studies can be undertaken in other medical colleges in the country and in nursing and pharmacy colleges also.