“…As expected, cannabis cues consistently produced elevated craving relative to neutral cues, extending prior CREMA findings from tobacco/cigarette use to cannabis use (Tomko et al, 2020;Warthen & Tiffany, 2009;Wray et al, 2015). Somewhat consistent with our hypotheses based on the motivational model (Cooper, 1994;Cox & Klinger, 1988) and theories of craving (Heishman et al, 2009;Jellinek et al, 1955;Ludwig & Wikler, 1974;Marlatt, 1978;Wise, 1988), motives interacted with cue type to predict craving reactivity; however, not in the way we expected. The approach motive we focused on, enhancement, was associated with greater relief craving reactivity to cannabis cues relative to neutral cues, and the avoidance motive, coping, was associated with greater reward craving reactivity to cannabis cues, in women especially.…”