The critical role of Faecalibacterium prausnitzii in human health: An overview

Leylabadlo, Hamed Ebrahimzadeh; Feizabadi, Mohammad Mehdi; Farajnia, Safar; Moaddab, Yaghoub; Ganbarov, Khudaverdi; Khodadadi, Ehsaneh; Tanomand, Asghar; Baghi, Hossein Bannazadeh; Yousefi, Bahman; Kafil, Hossein Samadi

doi:10.1016/j.micpath.2020.104344

Cited by 144 publications

(86 citation statements)

References 171 publications

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“…Another common bacterium with increased abundance in active individuals is Faecalibacterium prausnitzii. This Firmicutes member is associated with immunomodulatory properties, leading to reduced levels of IL-2, the production of Interferon-gamma, and increased secretion of the anti-inflammatory cytokine IL-10 [70]. Evidence suggests a link between F. prausnitzii depletion and the onset of inflammatory bowel disease and Crohn's disease.…”

Section: Plos Onementioning

confidence: 99%

Association between physical activity and changes in intestinal microbiota composition: A systematic review

et al. 2021

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Introduction The intestinal microbiota comprises bacteria, fungi, archaea, protists, helminths and viruses that symbiotically inhabit the digestive system. To date, research has provided limited data on the possible association between an active lifestyle and a healthy composition of human microbiota. This review was aimed to summarize the results of human studies comparing the microbiome of healthy individuals with different physical activity amounts. Methods We searched Medline/Ovid, NIH/PubMed, and Academic Search Complete between August–October 2020. Inclusion criteria comprised: (a) cross-sectional studies focused on comparing gut microbiome among subjects with different physical activity levels; (b) studies describing human gut microbiome responses to any type of exercise stimulus; (c) studies containing healthy adult women and men. We excluded studies containing diet modifications, probiotic or prebiotic consumption, as well as studies focused on diabetes, hypertension, cancer, hormonal dysfunction. Methodological quality and risk of bias for each study were assessed using the Risk Of Bias In Non-randomized Studies—of Interventions tool. The results from cross-sectional and longitudinal studies are shown independently. Results A total of 17 articles were eligible for inclusion: ten cross-sectional and seven longitudinal studies. Main outcomes vary significantly according to physical activity amounts in longitudinal studies. We identified discrete changes in diversity indexes and relative abundance of certain bacteria in active people. Conclusion As literature in this field is rapidly growing, it is important that studies incorporate diverse methods to evaluate other aspects related to active lifestyles such as sleep and dietary patterns. Exploration of other groups such as viruses, archaea and parasites may lead to a better understanding of gut microbiota adaptation to physical activity and sports and its potentially beneficial effects on host metabolism and endurance.

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Section: Plos Onementioning

confidence: 99%

Association between physical activity and changes in intestinal microbiota composition: A systematic review

et al. 2021

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“…Furthermore, its abundance was shown to be increased in long-term PPI use and was associated with mortality in cirrhosis [175]. The commensal, butyrate-producing bacterium Faecalibacterium prausnitzii is highly abundant in human feces and exerts anti-inflammatory effects through secretion of salicylic acid and inhibition of cytokines activating inflammation cascades [212]. Its reduction was demonstrated earlier in liver diseases like NAFLD, in gastrointestinal disorders like IBD, IBS, and colon cancer, and in metabolic diseases like diabetes mellitus type 2 and obesity as well as in neurologic and psychiatric diseases [212].…”

Section: Pscmentioning

confidence: 99%

The Gut-Liver Axis in Cholestatic Liver Diseases

Blesl

Stadlbauer

2021

Nutrients

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The gut-liver axis describes the physiological interplay between the gut and the liver and has important implications for the maintenance of health. Disruptions of this equilibrium are an important factor in the evolution and progression of many liver diseases. The composition of the gut microbiome, the gut barrier, bacterial translocation, and bile acid metabolism are the key features of this cycle. Chronic cholestatic liver diseases include primary sclerosing cholangitis, the generic term secondary sclerosing cholangitis implying the disease secondary sclerosing cholangitis in critically ill patients and primary biliary cirrhosis. Pathophysiology of these diseases is not fully understood but seems to be multifactorial. Knowledge about the alterations of the gut-liver axis influencing the pathogenesis and the outcome of these diseases has considerably increased. Therefore, this review aims to describe the function of the healthy gut-liver axis and to sum up the pathological changes in these cholestatic liver diseases. The review compromises the actual level of knowledge about the gut microbiome (including the mycobiome and the virome), the gut barrier and the consequences of increased gut permeability, the effects of bacterial translocation, and the influence of bile acid composition and pool size in chronic cholestatic liver diseases. Furthermore, therapeutic implications and future scientific objectives are outlined.

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“…Many of these ASVs are members of bacterial genera that are typically beneficial to gut health such as Bifidobacterium and Faecalibacterium (Table 2). 22,23 Gut colonization of these bacteria appears discouraged by autoimmunityassociated high-risk haplotypes such as DR3-DQ2 ((DR3)-DQA1*05-DQB1*02) or DR4-DQ8 but encouraged by other alleles such as DR7-DQ2 ((DR7)-DQA1*02:01-DQAB1*02) and DR9-DQ9 ((DR9)-DQA1*03-DQB1*03:03) (Fig. 2C, Supplemental Table 1).…”

Section: Effect Of Hla Host Genetics On Colonization By Cases-and Controls-specific Asvsmentioning

confidence: 99%

“…infantis or Faecalibacterium prausnitzii. 22,23 Two different strains of Collinsella aerofaciens, one with 100% and the other with 99•8% identity to strain JCM10188, make up 20% of the controls-exclusive ASVs. Notably, F. prausnitzii and C. aerofaciens are butyrate producers.…”

Section: Characteristics Of Controls-exclusive Asvs From the Genera Bifidobacterium Faecalibacterium Collinsella Akkermansia And Romboutsmentioning

confidence: 99%

Adolescent autism and autoimmune diagnoses linked to infant gut bacteria whose prevalence is associated with at-risk genetics and/or diet

et al. 2021

Preprint

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The earliest predictors of future autoimmune diseases are a series of autoantibodies that are rarely evaluated and very within and between diseases. In addition, autoantibodies often appear just prior to disease onset. All of these factors make it difficult to apply interventions that might prevent disease. Earlier predictors of disease are needed. Here, a general population cohort was used to assess whether gut bacterial biomarkers could be identified prior to disease. Gut microbiome analysis on 1,741 one-year old Swedish children was performed on samples collected in the late 1990s. These children were then followed for 18 years for the incidence of five autoimmune diseases and autism. Specific bacterial strains in the gut microbiome of one-year-old children have been identified as exclusive to the 96 subjects (cases) who acquired type 1 diabetes, celiac disease, hypothyroidism, Crohns disease, juvenile idiopathic arthritis, or autism over their next 18 years. None of these strains were found in the 1,645 children (controls) who did not acquire any of these diseases. Ten other strains were exclusive to those who remained disease-free. In most cases, the presence or absence of these bacteria were strongly associated with: 1) high-risk class II human leukocyte antigen (HLA) alleles; 2) dietary factors; or 3) a combination of HLA genetics and diet. These results have three significant implications: 1) certain class II HLA haplotypes may serve as bacterial gatekeepers early in life, altering microbiome composition thereby creating the potential for dysbiosis and inflammation; 2) the gut microbiome dysbiosis and inflammation during infancy, largely derived from host HLA genetics and diet, may be a common precedent to all five autoimmune diseases and autism; and 3) HLA gatekeeping may prevent gut colonization of beneficial bacteria in those genetically at-risk individuals who could most benefit from probiotic therapy.

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The critical role of Faecalibacterium prausnitzii in human health: An overview

Cited by 144 publications

References 171 publications

Association between physical activity and changes in intestinal microbiota composition: A systematic review

Association between physical activity and changes in intestinal microbiota composition: A systematic review

The Gut-Liver Axis in Cholestatic Liver Diseases

Adolescent autism and autoimmune diagnoses linked to infant gut bacteria whose prevalence is associated with at-risk genetics and/or diet

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