The cross-disciplinary emergence of 3D printed bioceramic scaffolds in orthopedic bioengineering

Jazayeri, Hossein E.; Rodriguez-Romero, Martin; Razavi, Mehdi; Tahriri, Mohammadreza; Ganjawalla, Karan; Rasoulianboroujeni, Morteza; Malekoshoaraie, Mohammad H.; Khoshroo, Kimia; Tayebi, Lobat

doi:10.1016/j.ceramint.2017.09.095

Cited by 49 publications

(22 citation statements)

References 97 publications

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“…The results of bone reconstruction are dependent on the surgical skills, the quality of the adjacent tissue, the size and location of the bone defect, as well as the method of repairing the bone defect. Current methods of reconstruction include simple or vascularized bone grafts, the use of biomaterials, and, more recently, the use of growth factors to induce osteoinduction [1].…”

Section: Introductionmentioning

confidence: 99%

“…It is possible that the bone tissue taken may require reshaping into custom shapes, which may complicate the surgical operation. Also, complications in the case of simple bone grafts include graft resorption and increased mortality associated with the sampling area [1].…”

Section: Introductionmentioning

confidence: 99%

“…For osteosynthesis, titanium alloy prostheses offer major advantages in terms of biocompatibility, stability, and individual implant placement. Removal of asymptomatic prostheses and screws after fracture healing is still controversial due to the fact that the removal procedure could damage the bone [1].…”

Section: Introductionmentioning

confidence: 99%

“…An optimal biomaterial meets all the requirements: biocompatibility, stability, intraoperative matching, product safety, and low costs; in reality, the perfect material has not yet been found. The development of future materials aims to improve the physical and biological properties, especially regarding surface interactions [1].…”

Section: Introductionmentioning

confidence: 99%

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Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Piticescu¹,

Cursaru²,

Negroiu³

et al. 2020

Biomaterials

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Barium titanate (BT) and barium strontium titanate (BST) are one of the most studied ferroelectric materials with excellent piezoelectric properties, which can be used to stimulate bone formation by applying an electrical field. It is known that this ceramic is biocompatible and can be used for medical applications. New hybrid materials based on BT and collagen and BST and collagen, with potential applications in bone reconstruction, are presented, emphasizing the potential of fabricating 3D structures by integrating hydrothermal synthesis with additive manufacturing. Designing such structures may take advantage of rheological characterization at single-molecule level for some elastic biopolymers like titin and collagen and their molecular dissection into structural motifs that independently contribute to the protein viscoelasticity. Atomic force spectroscopy measurements on synthetic polypeptides showed that a polypeptide chain containing Ig domain modules is protected against rupture at high stretch by Ig domain unfolding, an important mechanism for stress relaxation in titin molecules. This property may be exploited to enhance the tensile strength of a 3D structure by adding specific synthetic polypeptides to the composition of the printing paste.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Piticescu¹,

Cursaru²,

Negroiu³

et al. 2020

Biomaterials

View full text Add to dashboard Cite

show abstract

“…In regard to tissue engineering of a particular cartilage, although implanting artificial matrices, growth factors, perichondrium, and periosteum can initiate the formation of cartilaginous tissue in osteochondral and chondral defects in synovial fluids, the results vary considerably from patient to patient [16]. A successful scaffold is one that fits the anatomical defects defined from clinical imaging data, while also having a design that is porous and that can balance load bearing and biofactor delivery requirements [17][18][19][20][21][22][23][24][25][26][27][28][29][30]. For these designs, the global image design database is created from a computed tomography (CT) or magnetic resonance (MR) image of a patient.…”

Section: Introductionmentioning

confidence: 99%

Cartilage and facial muscle tissue engineering and regeneration: a mini review

et al. 2018

Self Cite

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Cartilage and facial muscle tissue provide basic yet vital functions for homeostasis throughout the body, making human survival and function highly dependent upon these somatic components. When cartilage and facial muscle tissues are harmed or completely destroyed due to disease, trauma, or any other degenerative process, homeostasis and basic body functions consequently become negatively affected. Although most cartilage and cells can regenerate themselves after any form of the aforementioned degenerative disease or trauma, the highly specific characteristics of facial muscles and the specific structures of the cells and tissues required for the proper function cannot be exactly replicated by the body itself. Thus, some form of cartilage and bone tissue engineering is necessary for proper regeneration and function. The use of progenitor cells for this purpose would be very beneficial due to their highly adaptable capabilities, as well as their ability to utilize a high diffusion rate, making them ideal for the specific nature and functions of cartilage and facial muscle tissue. Going along with this, once the progenitor cells are obtained, applying them to a scaffold within the oral cavity in the affected location allows them to adapt to the environment and create cartilage or facial muscle tissue that is specific to the form and function of the area. The principal function of the cartilage and tissue is vascularization, which requires a specific form that allows them to aid the proper flow of bodily functions related to the oral cavity such as oxygen flow and removal of waste. Facial muscle is also very thin, making its reproduction much more possible. Taking all these into consideration, this review aims to highlight and expand upon the primary benefits of the cartilage and facial muscle tissue engineering and regeneration, focusing on how these processes are performed outside of and within the body.

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Mechanical, thermal, and dielectric properties of polyvinylidene fluoride nanocomposites fabricated by introducing functional MWCNTs/barium titanate compounding dielectric nanofillers

et al. 2020

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A facile strategy through incorporating barium titanate (BT)/multiwalled carbon nanotubes (MWCNTs) compounding dielectric nanofillers into polyvinylidene fluoride (PVDF) via melt-processing was proposed. Benefiting from the strong interfacial interactions between BT and MWCNTs, as well as oxygen-containing groups of BT/MWCNTs and fluorine atoms of PVDF, the sandwiched structure was constructed and thus tailoring the microstructure and enhancing the mechanical, thermal and dielectric properties of resultant nanocomposites. The effects of BT/MWCNTs multiscale dielectric nanofiller on the mechanical properties, heat resistance and dielectric properties of nanocomposites were investigated by infrared spectra, X-ray diffraction (XRD), differential scanning calorimetry (DSC) analysis, field emission scanning electron microscope, tensile and dielectric tests. XRD and DSC analysis indicated that compared with neat PVDF, BT/PVDF and MWCNTs/PVDF nanocomposites, the BT/MWCNTs/PVDF nanocomposites showed higher crystallinity and thermal properties. The dielectric performance tests showed that the BT/MWCNTs/PVDF nanocomposites had better dielectric performance than those of BT/PVDF and MWCNTs/PVDF nanocomposites. At 100 Hz, the dielectric constant of BT/MWCNTs/PVDF nanocomposites reached 119, which was 14 times that of neat PVDF, and the dielectric loss was only 0.051. The BT/MWCNTs/PVDF nanocomposites showed the tensile strength of 57.7 MPa and the tensile modulus of 1226 MPa, respectively. This work provides a novel strategy for the fabrication of PVDF based dielectric nanocomposites, inspiring the research and development of PVDF in the energy-related areas in the future.

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The cross-disciplinary emergence of 3D printed bioceramic scaffolds in orthopedic bioengineering

Cited by 49 publications

References 97 publications

Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Cartilage and facial muscle tissue engineering and regeneration: a mini review

Mechanical, thermal, and dielectric properties of polyvinylidene fluoride nanocomposites fabricated by introducing functional MWCNTs/barium titanate compounding dielectric nanofillers

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