“…showed the good antibacterial activity of 2D reduced graphene oxide supported Au nanostar nanocomposites under NIR irradiation for methicillin-resistant S. aureus (MRSA) bacteria due to the synergistic antibacterial activity [ 64 ]. Moreover, some studies have combined the intrinsic antibacterial activity of NPs with photothermal therapy to decrease the dose of nanoparticles as well as NIR exposure time [ 65 ]. Fig.…”
“…showed the good antibacterial activity of 2D reduced graphene oxide supported Au nanostar nanocomposites under NIR irradiation for methicillin-resistant S. aureus (MRSA) bacteria due to the synergistic antibacterial activity [ 64 ]. Moreover, some studies have combined the intrinsic antibacterial activity of NPs with photothermal therapy to decrease the dose of nanoparticles as well as NIR exposure time [ 65 ]. Fig.…”
“…Wang et al [169] prepared multimetallic NPs consisting of CuO and ZnO and Au, which, when exposed to laser light at a wavelength of 635 nm, killed almost 100% of S. aureus and E. coli (97.5%) after 10 min of exposure. Ye et al reported the antibacterial efficacy of CuO@AgO/ZnO NPs exposed to near infrared (NIR) light against S. aureus and Pseudomonas aeruginosa [170]. In addition to the nanopreparations already used in clinical practice, new studies are being published.…”
Section: Dressings Made Of Nanomaterials (Nms)mentioning
According to the World Health Organization (WHO), around 11 million people suffer from burns every year, and 180,000 die from them. A burn is a condition in which heat, chemical substances, an electrical current or other factors cause tissue damage. Burns mainly affect the skin, but can also affect deeper tissues such as bones or muscles. When burned, the skin loses its main functions, such as protection from the external environment, pathogens, evaporation and heat loss. Depending on the stage of the burn, the patient’s condition and the cause of the burn, we need to choose the most appropriate treatment. Personalization and multidisciplinary collaboration are key to the successful management of burn patients. In this comprehensive review, we have collected and discussed the available treatment options, focusing on recent advances in topical treatments, wound cleansing, dressings, skin grafting, nutrition, pain and scar tissue management.
“…Furthermore, great efforts have been spared for a synergistic antibacterial effect. According to previous reported studies, copper-based nanoagents with exceptional biocompatibility and efficacious sterilization have attracted substantial attention in wound healing. , Of particular interest is the utilization of Cu 2+ , as it has been demonstrated to stimulate angiogenesis, accelerate the proliferation and migration of keratinocyte, and boost collagen deposition that prominently led to the amplification of the wound healing effect. , However, because of the microporous structure of the reported hydrogels, it remains a daunting challenge to quickly and uniformly anchor Cu 2+ in wound dressing.…”
Section: Introductionmentioning
confidence: 99%
“… 38 , 39 Of particular interest is the utilization of Cu 2+ , as it has been demonstrated to stimulate angiogenesis, accelerate the proliferation and migration of keratinocyte, and boost collagen deposition that prominently led to the amplification of the wound healing effect. 40 , 41 However, because of the microporous structure of the reported hydrogels, it remains a daunting challenge to quickly and uniformly anchor Cu 2+ in wound dressing.…”
Triggering the healing
process of drug-resistant bacteria-infected
wounds has attracted great attention due to global morbidity that
may induce gangrene, amputation, and even death. Here, a chitin derivative,
carboxymethyl chitosan (CMC), tannic acid (TA), and Cu2+ were used for hydrogel engineering. Using sodium bicarbonate as
the neutralizer and reductant, hydrogen bonds between CMC and TA and
in situ Cu(OH)2 generation via ion coordination force between
Cu2+ and TA facilitated the synthesis of CMC/TA/Cu hydrogel.
Cu2+ and TA release, cytotoxicity, in vitro cell migration,
angiogenesis, and antidrug-resistant bacteria were measured. Besides,
wound closure was evaluated in vivo using the methicillin-resistant Staphylococcus aureus (MRSA)-infected excisional
dermal wound mouse model. Negligible toxicity was observed both in
vitro and in vivo. Dermal cell migration and angiogenesis were significantly
enhanced. In vivo, the CMC/TA/Cu hydrogel induced effective re-epithelialization,
collagen deposition, inflammatory alleviation, and MRSA inhibition
during wound repair in mice. All these results confirmed that the
CMC/TA/Cu hydrogel is a promising novel dressing for chronic wound
healing in clinic.
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