The curious tale of perioperative precision medicine: a story of hydroxocobalamin and cardiac surgery-associated vasoplegia

A Change of Tide or the Beginning of the End: COVID-19

“…While this may be a reasonable assumption, from our original case series, we were unable to achieve a complete response (increase in mean arterial pressure >65 mm Hg within 15 to 30 minutes, sustained for >60 minutes post-B 12 administration) from all patients, 27% showed a poor response, 24% showed some response, 27% sustained response, and 21% had rebound hypotension. 34 The basis of this widespread “phenotypic” response probably lies in genomics and epigenomics of “Precision Medicine.” 35,36 Likewise, until further studies are performed, it may not be that every patient on SSRI will develop serotonin syndrome, but always worth considering the potential complication prior to administration.…”