The current management of hydatid disease

Taylor, D. H.; Morris, D. L.

doi:10.1111/j.1742-1241.1988.tb08614.x

Cited by 6 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydatid disease continues to be an important, endemic problem in many parts of the world including Turkey. Surgical intervention is still the preferred method of treatment, but it carries the risk of intraoperative spillage of scolices [1,2]. Although injecting scolicidal solution into the hydatid cyst and preserving the operative field with sponges soaked in scolicidal agents have been used to avoid disseminating the parasite during surgery, intraperitoneal hydatidosis (IPH) remains the most important complication of hydatid cyst surgery.…”

mentioning

confidence: 99%

Chlorhexidine Gluconate: An Ideal Scolicidal Agent in the Treatment of Intraperitoneal Hydatidosis?

et al. 2005

View full text Add to dashboard Cite

Hydatid disease is a parasitic disease that is treated primarily by surgery. The most important complication of surgical treatment is spillage of the contents of the cyst, leading to secondary dissemination. In this study, the effect of chlorhexidine gluconate (Chx-Glu) was investigated in the treatment of experimental intraperitoneal hydatidosis (IPH). IPH was reproduced in 100 Wistar albino rats by inoculation with 1 ml of a suspension contained approximately 1500 viable protoscolices of Echinococcus granulosus following determination of scolicidal activity of chlorhexidine gluconate in vitro. Five minutes after protoscolex inoculation, 5 ml of the scolicidal solution was instilled into the peritoneal cavity: 0.9% NaCl (control group), 4.0% Chx-Glu, 0.4% Chx-Glu, and 0.04% Chx-Glu. After 6 months of follow-up, the rats were sacrificed, and the number of isolated cysts, peroperative and postoperative deaths, and toxicity were evaluated. Cyst formation did not occur in any of the Chx-Glu groups compared to the control group (p < 0.05), whereas it was detected in all of the control rats. In addition, to 4.0% Chx-Glu was found to be more toxic and to cause a high mortality rate compared to the 0.4% and 0.04% Chx-Glu groups and the control group (p < 0.05). Chx-Glu 0.04% was found to be the most potent, nontoxic agent; it is easily available, inexpensive, and highly potent in a short period of time at the low concentration. Chx-Glu 0.04% can be used safely in the treatment of intraperitoneal hydatidosis and hydatid cyst.

show abstract

mentioning

confidence: 99%

Chlorhexidine Gluconate: An Ideal Scolicidal Agent in the Treatment of Intraperitoneal Hydatidosis?

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Surgical intervention is still the preferred method of treatment, but it carries the risk of intraoperative spillage of scolices 5,6. Although injecting a scolicidal solution into the hydatid cyst and preserving the operative field with sponges soaked in scolicidal agents have been used to avoid dissemination of the parasite during surgery, intraperitoneal hydatidosis (IPH) remains the most important complication of hydatid cyst surgery.…”

mentioning

confidence: 99%

Effects of Peritoneal Lavage with Scolicidal Agents on Survival and Adhesion Formation in Rats

2005

View full text Add to dashboard Cite

Intraoperative irrigation of the peritoneal cavity with scolicidal agents is frequently recommended when dealing with traumatic or spontaneous rupture of hydatid cysts. The present experimental study was designed to examine the influence of various scolicidal agents on adhesion formation and survival. A total of 149 rats were randomly allocated to nine groups. Peritoneal lavage through a median laparotomy was performed with the following scolicidal agents. Group 1 (0.9% saline: controls), group 2 (20% hypertonic saline), group 3 (0.04% chlorhexidine gluconate), group 4 (3% hydrogen peroxide), group 5 (0.5% silver nitrate), group 6 (1% polyvinylpyrrolidone-iodine, or PVP-I ), group 7 (5% PVP-I), group 8 (0.5% cetrimide/0.05% chlorhexidine), and group 9 (10% PVP-I). The surviving animals were sacrificed on postoperative day 15. Adhesion formation was macroscopically graded by the Nair criteria. The severity of adhesion formation was evaluated microscopically using the fibrosing scoring criteria and the strain test. Group 9 (10% PVP-I) was excluded from the adhesion evaluation because all of the rats died in this group. The mortality rate was significantly higher in groups 5 and 7 than in groups 1, 2, 3, 4, 6, and 8. Adhesion scores were significantly lower in groups 1, 2, 3, and 4 than in groups 5, 6, 7, and 8. The lowest adhesion score was found in group 3 and the highest in the group 7. These results indicate that 0.04% chlorhexidine gluconate, the most potent scolicidal agent in vitro and in vivo, was associated with the lowest adhesion formation and mortality among various scolicidal agents in this experimental study.

show abstract

Echinococcosis — a plague on pastoralists

Macpherson¹,

Craig

1991

Parasitic Helminths and Zoonoses in Africa

View full text Add to dashboard Cite

The current management of hydatid disease

Cited by 6 publications

References 34 publications

Chlorhexidine Gluconate: An Ideal Scolicidal Agent in the Treatment of Intraperitoneal Hydatidosis?

Chlorhexidine Gluconate: An Ideal Scolicidal Agent in the Treatment of Intraperitoneal Hydatidosis?

Effects of Peritoneal Lavage with Scolicidal Agents on Survival and Adhesion Formation in Rats

Echinococcosis — a plague on pastoralists

Contact Info

Product

Resources

About