The Current Scenario of Vitamin B12 Deficiency by Long Term Metformin Therapy in Diabetes Mellitus - Type 2 Patients

Abstract

Since the history to this present date, Metformin falls under the category of commonly used anti -diabetic drugs in the therapy of type animal protein, during the metabolism process it is mediated by the action of pepsin and gastric acid, after which it binds to R protein, which is secreted by the salivary gland under hydrolyzed condition, it releases the vitamin B12 which binds to the intrinsic factor (IF) secreted by gastric parietal cells which in result leads to the formation of a complex which gets attached to the specific receptors of mucosa in the terminal ileum region, this stage is usually calcium mediated. KEYWORDS:There have been some concern over the risk of vitamin B12 deficiency.