1Endotoxic shock can be elicited by a systemic injection of LPS which induces the production and release of several cytokines.2 In response to these cytokines, several reactive oxygen species (ROS) are produced from cells such as neutrophils and other phagocytic cells, creating a status of oxidative stress.3 Thus, this type of stress may hypothetically support the assumption that LPSinduced cell injury would be retarded by modifying free radical metabolism with the aid of potent antioxidant pre-treatment from nature. Certain reports have claimed that a few herbal extracts can act on the central nervous system, thereby enhancing the faculties of learning and memory. 4 The . At the end of the study, rats were sacrificed, brain hippocampal region was removed and biochemical parameters were measured. Results: In WMT swimming length (cm) was increased in LPS-treated rats when compared to control animals, the swimming length (EEPM; 400 mg/kg) was found to be significant; in RAM, different doses of EEPM at 100, 200 and 400 mg/kg decreased the number of errors in entry 4.00±0.36, 4.16±0.16and 3.33±2.79 respectively when compared with control animals (2.66± 0.21). EEPM at 400 mg/kg showed significant activity, in CRT apparatus increased incorrect lever pressing was observed in LPS-treated rats when compared to control animals. Incorrect lever pressing was minimized by EEPM at 400 mg/kg (43.5±2.40). Conclusions: Our results showed that EEPM is a hopeful aspirant for hindrance of infection and inflammation induced brain damage by LPS.

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A new phenolic glycoside, 3, 5 - dihydroxy - 2- (hydroxyl methyl) - 6-(3,4,5-trimethoxy phenoxy)tetrahydro-2H-pyran-4-yl, 4-hydroxy-3-methoxy benzoate have been isolated from the dried bark ofSymplocos racemosa. The structure was identified by extensive spectral analysis, especially FT-IR, GC-MS,1H NMR and13C NMR techniques. The method of isolation was simple, cost effective and efficient. The preliminary bioactivity of the compound was also evaluated. The ethanolic extract ofSymplocos racemosa(EESR) was investigated for its anti-pyretic activity against brewer’s yeast induced pyrexia. The antipyretic effect of EESR (measured as % reduction in body temperature) was compared with paracetamol (100 mg/kg, orally). EESR in dose of 200 mg/kg caused significant decrease in body temperature of rats. This study has established the antipyretic activity ofSymplocos racemosaand thus, justifies the ethnic uses of the plant.

Background: A new series of copper (II), cobalt (II), zinc (II), manganese (II), iron (II) metal complexes were synthesized by the condensation of novel schiff base with various metal chlorides in ethanol. Schiff base was synthesized by reacting salicylaldehyde with L-glutamic acid and L-tyrosine dissolved in ethanol respectively . Methods: All the synthesized metal complexes structures(4a-e, 7a-e)were investigated using elemental analysis, FT-IR,1H NMR,13C NMR and MS spectral data. The metal complexes were also screened for their anti-bacterial, anti-fungal and anti-tubercular activityagainst various tested strains. Results: Assessment of in silico ADMET properties of all metal complexes derivatives showed agreement to Lipinski’s rule of five. The further enzymatic assay was aided by a molecular docking study of Enoyl CoA reductase (INHA) using Autodock vina and evaluated by Autodock 4.0. Conclusion: The metal complexes 4b,4c, 4d,7b and 7d containing metals like Zn, Co, and Fe derivatives showed good anti-bacterial, anti-fungal and anti-tubercular activity against tested strains were more than the standard.

Many diseases have become easier to diagnose and treat as a result of advancements in medical science and technology, but strokes, which have multiple etiologies and mechanisms, continue to be difficult to treat. Synthetic drugs are notorious for causing a slew of unavoidable side effects. Herbal drugs have a wide range of mechanisms of action and are typically free of side effects, making them excellent alternatives to synthetic drugs for stroke treatment. Cyclea peltata (Lam) Hook f. Thoms roots were studied for their neuroprotective properties against fluoride-induced neurodegeneration in rats. The rat brain homogenate was investigated for the levels of non-enzymatic antioxidants like norepinephrine and serotonin to analyse the health of the brain. Both the hormones norepinephrine and serotonin levels were restored due to the treatment with ethanol extract of the plant. The antioxidant enzyme levels like SOD, CAT, GSH and GPx in the rat brain were estimated, and the results were similar to the non-enzymatic levels. The elevation of antioxidant enzymes indicates that the extract had an antioxidant mechanism that is responsible to help in the prevention of neurodegeneration of rats. In the brain tissues treated with Cyclea peltata extract, there was a significant increase in antioxidant enzymes and a reduction in lipid peroxidation, confirming the antioxidant mechanisms responsible for stroke prevention in extract-treated groups. The root extract of Cyclea peltata was found to show a reasonable inhibitory effect on neurodegeneration when delivered at a dose of 200mg/kg.