Isolation and Characterization of Phenolic Glycoside from the Bark of <i>Symplocos Racemosa</i>Roxb

Vijayabaskaran, M.; Yuvaraja, K. R.; Babu, G.; Perumal, Pandurangan; Jayakar, B.

doi:10.1155/2010/570736

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…Vijayabaskaran et al [36] also reported in vitro antioxidant potential of ethanolic bark extract of Symplocos racemosa Roxb.…”

Section: Resultsmentioning

confidence: 98%

In vitro Antioxidant Potential of Methanolic Extract of Symplocos racemosa Roxb.

Kar¹,

Panda²

2017

Asian J. Chem.

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Many hazardous diseases are caused by free radicals accumulation. A number of investigations are focusing to find out the plant oriented natural antioxidant moieties. The basic aim of this research was to investigate the antioxidant potential of different plant parts of the crude methanolic extract of Symplocos racemosa. Symplocos racemosa (Symplocaceae) commonly known as "Lodhra" and is useful in diarrhoea, dysentery, eye diseases, fever, ulcer, scorpion sting, diabetes and liver disorders. Here the bark, leaf and root were screened for in vitro antioxidant activity study using DPPH, nitric oxide, hydroxyl radical and ABTS assay methods. Both ascorbic acid and rutin are used as a standard. The results of the study indicated that the methanolic extract of Symplocos racemosa showed potent antioxidant activity in ABTS assay method than other methods. These research investigations revealed that Symplocos racemosa is a potent source of natural antioxidants. Hence the plant can be used for management of different stress and anxiety related ailments. Keywords: Symplocos racemosa, Methanolic extract, Antioxidant activity.Asian Journal of Chemistry; Vol. 29, No. 10 (2017), 2271-2274 anticancer [17] and has beneficial effects in gynaecological disorders [18]. As there is no published data for the antioxidant potential of different parts of Symplocos racemosa, so this study was designed to investigate the antioxidant potential of the plant. EXPERIMENTAL Extraction of plant:The plant Symplocos racemosa (Family: Symplocaceae) was collected from Patbil, Karanjia, Mayurbhanj, India. Further, it was authenticated by the taxonomist Dr. Pratap Chandra Panda, Senior Scientist, Regional Plant Resources Centre (RPRC), Bhubaneswar, India and its voucher specimen (Voucher No. 10122) was deposited in the Herbarium of RPRC for further reference. After due authentication the barks, leaves and roots were dried in shade and powdered to obtain coarse powder. The coarse powder material (250 g) was subjected to extraction with methanol (95 % v/v) by using Soxhlet apparatus. The methanol extract was concentrated in vacuo and kept in a vacuum desiccator for complete removal of solvent. The yield was 9.3 % w/w with respect to dried powder [19].2,2-Diphenyl-1-picrylhydrazyl (DPPH) [Sigma-Aldrich, India], methanol, dimethyl sulphoxide, sodium nitroprusside, naphthyl ethylene diamine dihydrochloride, sulphanilic acid, potassium persulphate, ferric chloride, hydrogen peroxide, thiobarbituric acid, trichloro acetic acid, ascorbic acid and rutin were purchased from Merck India Ltd.

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“…Vijayabaskaran et al [36] also reported in vitro antioxidant potential of ethanolic bark extract of Symplocos racemosa Roxb.…”

Section: Resultsmentioning

confidence: 98%

In vitro Antioxidant Potential of Methanolic Extract of Symplocos racemosa Roxb.

Kar¹,

Panda²

2017

Asian J. Chem.

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“…is an evergreen tree which is commonly called as Lodhra is found in plains and lower hills throughout North and East India. It is reported to be used in the treatment of menorrhagia, other uterine disorders, inflammation, cleaning of uterus, liver and bowel complaints, tumors, asthma, fever, snake-bite and gonorrhea [5], [6], [7]. Composition and levels of bioactive compounds in plants vary with genetic factors, geographical origins, agricultural practices, harvesting and post harvesting processes, extraction processes etc.…”

Section: Introductionmentioning

confidence: 99%

FTIR Fingerprinting of Extracts of Symplocos racemosa Roxb. and Mimusops elengi L

2024

IJFMR

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The present study focuses on the FTIR fingerprint evaluation of hydro-alcoholic extract of two medicinal plants Symplocos racemosa Roxb. (Lodhra) and Mimusops elengi L. (Bakul). Extracts were prepared using bark of Symplocos racemosa Roxb. and flowers of Mimusops elengi L. by cold extraction using vertical shaking for 16 hrs. Mimusops elengi L. extract has shown presence of β-amryin, betulinic acid, lupeol, ursolic acid, basic acid, taraxerol by identification of alcoholic and carbonyl functional groups. Similarly, secondary metabolites like betulinic acid, ellagic acid, symposide, (-) – Epiafzelechin, β-amryin, betulin, oleanic acid were confirmed as functional groups for aromatic and carbonyl compounds were observed.

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“…Many species of this genus have been used as traditional herbal medicines for nephritis [19, 20]. The genus Symplocos mainly contains chemicals shown to have diverse biological activities, particularly anti-HIV activity, antitumor applications, antibacterial effects, and inhibitory activities against phosphodiesterase [21]. The compound 3 β -acetyloxy-oleanolic acid (AOA) was isolated from the root of Symplocos laurina Wall [22].…”

Section: Introductionmentioning

confidence: 99%

3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation

Zhou

Chen

Wei

et al. 2019

Journal of Immunology Research

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Th17 activity has been implicated in systemic lupus erythematosus (SLE), which is a systemic autoimmune disease with a typical clinical manifestation of lupus nephritis (LN). Retinoic acid receptor-related orphan receptor gamma t (RORγt) has been shown to be important for Th17 differentiation. In this study, we evaluated the inhibition of RORγt activity by 3β-acetyloxy-oleanolic acid (AOA), a small molecule isolated from the root of Symplocos laurina, a traditional herb belonging to South China. We demonstrated that AOA can inhibit RORγt activity and prevent SLE pathogenesis in a pristane-induced LN model. The results showed that AOA decreased RORγt transcription activity in a reporter assay and prevented Th17 differentiation in vitro. In vivo studies showed that AOA treatment decreased serum anti-dsDNA antibody and alleviated renal pathologic damage as well as antibody complex accumulation in the pristane-induced LN model. These results demonstrated that AOA can improve the clinical manifestation of LN, indicating potential application in SLE therapy.

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Isolation and Characterization of Phenolic Glycoside from the Bark of Symplocos RacemosaRoxb

Cited by 7 publications

References 7 publications

In vitro Antioxidant Potential of Methanolic Extract of Symplocos racemosa Roxb.

In vitro Antioxidant Potential of Methanolic Extract of Symplocos racemosa Roxb.

FTIR Fingerprinting of Extracts of Symplocos racemosa Roxb. and Mimusops elengi L

3β-Acetyloxy-oleanolic Acid Attenuates Pristane-Induced Lupus Nephritis by Regulating Th17 Differentiation

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