The current status of syphilis prevention and control in Jiangsu province, China: A cross-sectional study

Chen, Yuanfang; Ding, Jian-ping; Yan, Hongjing; Lu, Jing; Ding, Ping; Guo-hong, Chen; Liu, Jing; Huan, Xiping; Huang, Yang; Tang, Weiming; Fu, Gengfeng

doi:10.1371/journal.pone.0183409

Cited by 9 publications

(11 citation statements)

References 17 publications

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“…Syphilis is most transmissive during the primary and secondary (P&S) stages of its progression [ 7 ]. Early prevention of P&S syphilis can effectively stop its transmission [ 8 ]. Identifying areas with a high risk of P&S syphilis can provide recommendations for its early prevention, so that health services and resources can be more efficiently distributed [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal distribution and sociodemographic and socioeconomic factors associated with primary and secondary syphilis in Guangdong, China, 2005–2017

et al. 2021

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Background Previous studies exploring the factors associated with the incidence of syphilis have mostly focused on individual-level factors. However, recent evidence has indicated that social-level factors, such as sociodemographic and socioeconomic factors, also affect the incidence of syphilis. Studies on the sociodemographic and socioeconomic factors associated with syphilis incidence are scarce, and they have rarely controlled for spatial effects, even though syphilis shows spatial autocorrelation. Methodology/Principal findings Syphilis data from 21 cities in Guangdong province between 2005 and 2017 were provided by the National Notifiable Infectious Disease Reporting Information System. The incidence time series, incidence map, and space-time scanning data were used to visualize the spatiotemporal distribution. The spatial panel data model was then applied to explore the relationship between sociodemographic factors (population density, net migration rate, male:female ratio, and the number of health institutions per 1,000 residents), socioeconomic factors (gross domestic product per capita, the proportion of secondary/tertiary industry), and the incidence of primary and secondary syphilis after controlling for spatial effects. The incidence of syphilis increased slowly from 2005 (11.91 per 100,000) to 2011 (13.42 per 100,000) and then began to decrease, reaching 6.55 per 100,000 in 2017. High-risk clusters of syphilis tended to shift from developed areas to underdeveloped areas. An inverted U-shaped relationship was found between syphilis incidence and gross domestic product per capita. Moreover, syphilis incidence was significantly associated with population density (β = 2.844, P = 0.006), the number of health institutions per 1,000 residents (β = -0.095, P = 0.007), and the net migration rate (β = -0.219, P = 0.002). Conclusions/Significance Our findings suggest that the incidence of primary and secondary syphilis first increase before decreasing as economic development increases further. These results emphasize the necessity to prevent syphilis in regions at the early stages of economic growth.

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Section: Introductionmentioning

confidence: 99%

Spatiotemporal distribution and sociodemographic and socioeconomic factors associated with primary and secondary syphilis in Guangdong, China, 2005–2017

et al. 2021

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“…La principal medida para prevenir la sífilis es fomentar el uso de condón entre adolescentes y población vulnerable 21 , así como la adquisición del conocimiento de la enfermedad dentro de los programas de formación del recurso humano en salud y en los proveedores de servicios 22,23,24 . Para prevenir la SC las medidas más importantes son la búsqueda de la enfermedad en el momento en que la gestante accede al control prenatal, para brindar tratamiento a ella y a su pareja 25 , el estudio serológico debe repetirse en el momento del parto, y si la gestante no ha asistido a control prenatal, la serología para sífilis se hará en el momento del parto o en el posparto 5,27,29 .…”

Section: Sífilis Congénita Resultado De Unaunclassified

Sífilis congénita resultado de una Neurosífilis materna no diagnosticada. Reporte de caso

Cifuentes¹,

Angel‐Müller²,

Moreno³

2020

Rev. Medicas UIS

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En el mundo, se ha evidenciado un aumento de los casos de sífilis, de sífilis gestacional y de sífilis congénita. Se presenta el caso de un recién nacido con sífilis congénita,hijo de una madre con sífilis latente de duración indeterminada (VDRL 1:4 diluciones) diagnosticada y tratada a la semana 12 de gestación, VIH negativa, con compañero seronegativo para sífilis; a pesar del tratamiento con tres dosis de 2’400 000 U de penicilina benzatínica, no modificó los títulos del VDRL ni en el control de la semana 25 de gestación, ni en el momento del parto. En el posparto, la madre fue diagnosticada con neurosífilis y recibió tratamiento con penicilina cristalina durante 14 días. El recién nacido fue diagnosticado con sífilis congénita por presentar VDRL 1:4 diluciones, aumento de aminotransferasas, hematuria y proteinuria, recibiendo tratamiento con penicilina cristalina durante 10 días. La paciente evolucionó favorablemente y el control a los 6 meses fue normal.Deben fomentarse medidas útiles en la prevención de la sífilis gestacional: métodos de barrera, conocimiento de la enfermedad y asistencia a control prenatal. Es fundamental identificar y tratar a las gestantes con sífilis mediante tamizaje serológico para prevenir la sífilis congénita; el seguimiento serológico debe ser estricto para verificar la eficacia del tratamiento e investigar las gestantes que no modifican los títulos después del tratamiento. MÉD.UIS.2020;33(1):73-80

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“…Since the initiation of China’s national syphilis control plan, syphilis screening has been widely integrated into HIV voluntary counselling and testing (VCT) services. More than 95% of people who received HIV testing services have undergone free syphilis testing 30. Referral, treatment and follow-up services would be provided to those diagnosed with syphilis.…”

Section: Discussionmentioning

confidence: 99%

Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017

Wu¹,

Guan

Ye³

et al. 2019

BMJ Open

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ObjectiveThis study investigated the association between syphilis seroprevalence and age among blood donors, and described the distribution of serological titres among syphilis-infected donors, aiming to confirm the syphilis epidemic characteristics and to promote effective interventions for older adults.MethodsData were obtained from the Shenzhen Programme for Syphilis Prevention and Control in 2014–2017. Blood samples were screened using the ELISAs, and confirmed using the Treponema pallidum particle agglutination assay (TPPA) and toluidine red unheated serum test (TRUST).ResultsAmong 394 792 blood donors, 733 tested TPPA and TRUST positive (active infection), and 728 tested only TPPA positive (historical infection). The overall prevalence of syphilis seropositivity was 370.1 per 100 000 (95% CI 351.1 to 389.0 per 100 000); the prevalence of active infection was 185.7 per 100 000 (95% CI 172.2 to 199.1 per 100 000). People aged ≥45 years displayed a prevalence of 621.8 per 100 000 in syphilis seropositivity and 280.5 per 100 000 in active infection, which were 3.8 times and 2.4 times higher than that for people aged <25 years, respectively. The prevalence of syphilis seropositivity (χ2 trend=311.9, p trend<0.001) and active infection (χ2 trend=72.1, p trend<0.001) increased significantly with age. After stratification by gender and year of donation, the increasing trend of prevalence with age remained (p trend<0.05), except for the prevalence of active infection in males and females in 2014. About 16.3% of donors with active infection and aged ≥45 years had a TRUST titre of ≥1∶8, lower than that of patients aged <25 years (51.3%) and 25–34 years (34.1%).ConclusionsThe findings confirm the high prevalence of syphilis among older adults, and suggest the need to increase awareness among healthcare providers and deliver more targeted prevention interventions for older adults to promote early testing.

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The current status of syphilis prevention and control in Jiangsu province, China: A cross-sectional study

Cited by 9 publications

References 17 publications

Spatiotemporal distribution and sociodemographic and socioeconomic factors associated with primary and secondary syphilis in Guangdong, China, 2005–2017

Spatiotemporal distribution and sociodemographic and socioeconomic factors associated with primary and secondary syphilis in Guangdong, China, 2005–2017

Sífilis congénita resultado de una Neurosífilis materna no diagnosticada. Reporte de caso

Association between syphilis seroprevalence and age among blood donors in Southern China: an observational study from 2014 to 2017

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