2023
DOI: 10.3390/polym15030556
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The Current Status, Prospects, and Challenges of Shape Memory Polymers Application in Bone Tissue Engineering

Abstract: Bone defects can occur after severe trauma, infection, or bone tumor resection surgery, which requires grafting to repair the defect when it reaches a critical size, as the bone’s self-healing ability is insufficient to complete the bone repair. Natural bone grafts or artificial bone grafts, such as bioceramics, are currently used in bone tissue engineering, but the low availability of bone and high cost limit these treatments. Therefore, shape memory polymers (SMPs), which combine biocompatibility, biodegrada… Show more

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Cited by 21 publications
(6 citation statements)
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“…The recovery of the original morphology occurs when the polymer is reheated at an elevated temperature. This ability to recover its form after the applied stimulus can be particularly useful for the repair and recovery of bone defects [ 150 , 151 ]. This approach only functions with polymers whose Tg is lower or equivalent to body temperature.…”
Section: Stimulus and Effect On Responsive Materialsmentioning
confidence: 99%
“…The recovery of the original morphology occurs when the polymer is reheated at an elevated temperature. This ability to recover its form after the applied stimulus can be particularly useful for the repair and recovery of bone defects [ 150 , 151 ]. This approach only functions with polymers whose Tg is lower or equivalent to body temperature.…”
Section: Stimulus and Effect On Responsive Materialsmentioning
confidence: 99%
“…12 In particular, SMPs exhibit extraordinary potential for the advancement of space deployable structures 13,14 and bone tissue scaffolds. 15,16 Most SMPs are temperature-sensitive 17 and can return to a permanent shape from a temporary shape when exposed to a thermal stimulus. 18 For amorphous polymers, their distinctive shape memory (SM) behaviors arise from the glass transition.…”
Section: Introductionmentioning
confidence: 99%
“…Within the domain of SMMs, shape memory polymers (SMPs) 5–8 offer notable advantages in terms of light‐weight and cost‐efficient, enabling a wide range of prospective applications in functional textiles, 9 aerospace, 10,11 and biomedical medicine 12 . In particular, SMPs exhibit extraordinary potential for the advancement of space deployable structures 13,14 and bone tissue scaffolds 15,16 …”
Section: Introductionmentioning
confidence: 99%
“…Recently, the rapid development of shape memory polymers (SMPs) has provided a new strategy for the design of implants with minimal invasiveness. Although the recovery stress of SMPs is lower than that of the shape memory alloy, the easily tailoring structures of SMPs and their composites incorporated with versatile functional fillers make them not only present in response to various external stimuli, e.g., heat, light, magnetic fields, and pH, but also exhibit the controllable mechanical performance from soft to stiff . This unique property opens up tremendous potential for their application in various fields, including electronic devices, aerospace, tissue engineering, , cell behavior modulation, , and information coding .…”
Section: Introductionmentioning
confidence: 99%
“…18−20 Although the recovery stress of SMPs is lower than that of the shape memory alloy, the easily tailoring structures of SMPs and their composites incorporated with versatile functional fillers make them not only present in response to various external stimuli, e.g., heat, 21 light, 22 magnetic fields, 23 and pH, 24 but also exhibit the controllable mechanical performance from soft to stiff. 25 This unique property opens up tremendous potential for their application in various fields, including electronic devices, 23 tissue engineering, 27,28 cell behavior modulation, 29,30 and information coding. 31 For bone defect repair scaffolds, the shape memory effect (SME) not only facilitates the implantation with minimally invasive surgery but also endows the scaffold with fascinating shape-adaptable features especially for irregular defects.…”
Section: Introductionmentioning
confidence: 99%