2018
DOI: 10.1039/c8ob00138c
|View full text |Cite
|
Sign up to set email alerts
|

The Curtius rearrangement: mechanistic insight and recent applications in natural product syntheses

Abstract: The Curtius rearrangement is a versatile reaction in which a carboxylic acid can be converted to an isocyanate through an acyl azide intermediate under mild conditions. The resulting stable isocyanate can then be readily transformed into a variety of amines and amine derivatives including urethanes and ureas. There have been wide-ranging applications of the Curtius rearrangement in the synthesis of natural products and their derivatives. Also, this reaction has been extensively utilized in the synthesis and ap… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
84
0

Year Published

2018
2018
2024
2024

Publication Types

Select...
6

Relationship

1
5

Authors

Journals

citations
Cited by 106 publications
(84 citation statements)
references
References 124 publications
(132 reference statements)
0
84
0
Order By: Relevance
“…A large number of mild methods and a variety of reagents have been developed over the years. These methods have been reviewed in detail . In this section, we provide only a few selected convenient methods that have been used widely for medicinal chemistry applications.…”
Section: Convenient Methods and Reagentsmentioning
confidence: 99%
See 4 more Smart Citations
“…A large number of mild methods and a variety of reagents have been developed over the years. These methods have been reviewed in detail . In this section, we provide only a few selected convenient methods that have been used widely for medicinal chemistry applications.…”
Section: Convenient Methods and Reagentsmentioning
confidence: 99%
“…There are other recent methods and protocols that have been covered in recent reviews . In this review, we now highlight applications of the Curtius rearrangement in medicinal chemistry and drug development.…”
Section: Convenient Methods and Reagentsmentioning
confidence: 99%
See 3 more Smart Citations