The cutaneous manifestations of haematological malignancy

Fogo, A.; Vivier, Anthony du

doi:10.7861/clinmedicine.9-4-366

Cited by 10 publications

(4 citation statements)

References 15 publications

(8 reference statements)

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“…In recent years, cutaneous manifestations in patients with hematologic malignancies have become more common . The availability of new drugs has contributed to this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous manifestations of hematologic malignancies the experience of an Italian dermatology department

Merlo

Cozzani

Canale

et al. 2018

Hematological Oncology

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In recent years, dermatologic manifestations in oncohematologic patients have become more common. The aim of our study was to determine the incidence and heterogeneity of skin manifestations in patients followed at our Hematology Department. This observational monocentrical study was conducted on 60 patients. We divided the observed conditions in exanthematous, purpuric, vesicular‐bullous, papulonodular, urticarial, and eczematous manifestations. Moreover, all lesions were classified according to pathogenesis, in (a) specific skin manifestations, caused by neoplastic skin infiltration; (b) immune‐mediated manifestations, based on immunological mechanisms; and (c) skin lesions due to immunodeficiency. Altogether, 73 clinical manifestations were reported. Specific manifestations (a) were detected in 15.1% of the cases, mainly with papulonodular appearance. Immune‐mediated manifestations (b) were found in 37 cases (50.7%), particularly with eczematous or exanthematous appearance, and leukemia was the malignancy most frequently reported in these patients. Eventually, lesions due to immunosuppression (c) were reported in 34.2% of the cases. They were represented by infections and cutaneous malignancies, and usually manifested with papulonodular lesions. Skin lesions in oncohematologic patients are a common event. A multidisciplinary approach based on the collaboration between the hematologist and the dermatologist is crucial to achieve a proper diagnosis, and correctly manage these manifestations.

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“…In recent years, cutaneous manifestations in patients with hematologic malignancies have become more common . The availability of new drugs has contributed to this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous manifestations of hematologic malignancies the experience of an Italian dermatology department

Merlo

Cozzani

Canale

et al. 2018

Hematological Oncology

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Section: Question/discussion Points Partmentioning

confidence: 99%

“…These can cause discoloration and/or bruising of the skin that may be mistaken for purpuric lesions such as in Sweet syndrome. 4…”

Section: Question/discussion Points Partmentioning

confidence: 99%

“…Less common causes to consider include hematologic malignancies which could manifest in similar lesions (Sweet syndrome), and Kaposi sarcoma in the setting of severe immunodeficiency such as acquired immunodeficiency syndrome (AIDS). 4 Due to her age and lack of other findings including systemic symptoms, the greatest likelihood for the cause of her rash would be a hypersensitivity drug reaction to her recent use of hydrochlorothiazide.…”

Section: Discuss the Differential Diagnosis For The Presenting Lesionmentioning

confidence: 99%

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Educational Case: Hypersensitivity Vasculitis

MacLeod

Koponen

2021

Academic Pathology

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The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040 . 1

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The Skin and Disorders of the Haematopoietic and Immune Systems

Gniadecki

2016

Rook's Textbook of Dermatology, Ninth Edition

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This chapter reviews skin diseases and symptoms that develop secondarily to underlying malignant or benign diseases of the haematopoietic system. Skin lesions may be caused directly by infiltration of the skin with malignant cells (leukaemia cutis and lymphomatous infiltrates) or by paraproteins secreted by malignant plasma cells (amyloid light‐chain amyloidosis, type I cryoglobulinaemia and macroglobulinaemia cutis). A number of skin signs are an indirect effect of the underlying malignancy, such as paraneoplastic conditions or dermatological syndromes associated with haematological neoplasms (Schnitzler syndrome, POEMS, AESOP and TEMPI syndromes, neurofibromatosis, juvenile xanthogranuloma and juvenile myeloid leukaemia). Kikuchi–Fujimoto disease, Kimura disease, Rosai–Dorfman disease and IgG4‐related disease are idiopathic lymphoadenopathies presenting with characteristic skin lesions. Skin infections, eczematous lesions and vasculitis are the most common cutaneous signs of an underlying immunodeficiency. Chronic skin ulcers may accompany different haemoglobinopathies, such as thalassaemias and sickle cell anaemia. Finally, the skin signs of transfusion reactions (acute allergic reactions, transfusion‐associated graft‐versus‐host disease and post‐transfusion purpura) are reviewed. Diseases of the haematopoietic system often manifest themselves in the skin, and some manifestations are so typical that the dermatologist may be the first physician to detect the underlying blood disorder. More commonly, however, skin symptoms arise in the context of a known haematopoietic disease.

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The cutaneous manifestations of haematological malignancy

Cited by 10 publications

References 15 publications

Cutaneous manifestations of hematologic malignancies the experience of an Italian dermatology department

Cutaneous manifestations of hematologic malignancies the experience of an Italian dermatology department

Educational Case: Hypersensitivity Vasculitis

The Skin and Disorders of the Haematopoietic and Immune Systems

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