The CYP2A13 Arg257Cys Polymorphism and its Relationship to Lung Cancer

Soeroso, Noni Novisari; Sinaga, Bintang Yinke Magdalena; Zain-Hamid, Rozaimah; Sadewa, Ahmad Hamim; Syahruddin, Elisna

doi:10.1201/9781351190152-57

Cited by 2 publications

(3 citation statements)

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“…The Brinkman index in this study found that 75.7% of subjects were heavy smokers, 20% were moderate smokers, and the other 4.3% were light smokers. A similar result was also found by Soeroso et al, [ 15 ], [ 16 ] in which 52.9% of their research participants were categorised as heavy smokers. Also, this study was to evaluated nicotine dependence based on the Fagerstrom Tolerance Questionnaire (mFTQ), and the results showed that 65% of Fagerstrom scores were very high.…”

Section: Discussionsupporting

confidence: 89%

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Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Soeroso¹,

Tanjung²,

Afiani³

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Serum Procalcitonin (PCT) is a biomarker that is frequently used to diagnose an infection. In some cases of thoracic malignancy, procalcitonin level appears to increase. However, the role of procalcitonin to diagnose malignancy is not certain yet, and the causes have not been known.AIM:This study aimed to investigate procalcitonin levels in non-small cell lung cancer patients.METHODS:This was an observational study with a cross-sectional design. All lung cancer patients did not diagnose based on cytology/histopathology results with no evidence nor were signs and symptoms of infection recruited through consecutive sampling. The subtypes of lung cancer include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, staged III and IV. The procalcitonin levels were analysed from blood using immunofluorescent assay. Data were then analysed with the Chi-Square test by Epi Info™ 7 programs in which p-value < 0.05 was considered statistically significant.RESULTS:A total of 68 lung cancer patients fulfilled the criteria of this study, 55 men (80.9%) and 13 women (19.1%). The highest percentage of cytology/histopathology type found was adenocarcinoma (80.9%), and 60.3% of those were diagnosed in stage IV. An increased procalcitonin level (greater than 0.01 ng/mL) occurred in 80.9% of Non-Small Cell Lung Cancer (NSCLC) patients. It appears that the higher the stage of lung cancer, the lower procalcitonin levels would be, although it was not statistically significant. There was no association between lung cancer subtype with procalcitonin levels.CONCLUSION:An increased level of procalcitonin may be an indication not only for infection but also for Non-Small Cell Lung Cancer.

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Section: Discussionsupporting

confidence: 89%

“…Globally, cigarettes are one of the biggest death factors with a 1:10 ratio in adults and a mortality rate of about 5 million people per year [ 14 ]. Similarly, a study conducted by Soeroso in 2018 showed that 60% of lung cancer cases suffered by patients aged 55-64 years [ 15 ], [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Soeroso¹,

Tanjung²,

Afiani³

et al. 2018

Open Access Maced J Med Sci

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“…It has been reported that Arg257Cys polymorphism protects individuals with homozygous Cys257 allele against xenobiotic toxicity. 23 We found that CYP2A13 genotype was significantly associated with CT genotype and T allele, with 2.7-fold and 1.6-fold higher risk of lung cancer, respectively. These findings were different from previous reports.…”

Section: Discussionmentioning

confidence: 66%

Correlation between Genetic Polymorphism of CYP2A13 Genotype and Lung Cancer in Female Passive Smokers

Ramadhani

Soeroso

Tarigan

et al. 2022

Mol Cell Biomed Sci

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Background: Nicotine is metabolized to cotinine by cytochrome P450 enzyme, and this enzyme is involved in the activation of toxic and carcinogenic substances. The aim of this research was to assess the relationship between genetic polymorphism of CYP2A13 and lung cancer incidence in female passive smokers.Materials and methods: This research was a case-control study that involved 104 research subjects. Subjects were recruited through purposive sampling technique from 2 hospitals in Medan, North Sumatra, Indonesia. The case population consisted of female passive smokers with lung cancer and the control population consisted of female passive smokers without lung cancer. All research subjects underwent blood sampling for genomics DNA extraction and CYP2A13 genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Data was analyzed by conditional logistic regression by Epi Info 7.0 software.Results: Among 104 subjects, 26 (25%) individuals were heterozygous, 76 (73%) individuals were wild type, and 2 (2%) were mutant for the 257Cys allele. There was a significant correlation between CYP2A13 genotype and lung cancer incidence (p-value<0.05). Female passive smokers with CT genotype had 2.7 greater risk of developing lung cancer than those with CC genotype (wild type). The C allele had more frequency and 1.6 times higher risk of lung cancer compared to T allele with a wide confidence range (0.73–3.52).Conclusion: There was a significant correlation between CYP2A13 polymorphism and lung cancer incidence in female passive smokers.Keywords: polymorphism, CYP2A13, PCR-RFLP, female passive smoker, lung cancer

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The CYP2A13 Arg257Cys Polymorphism and its Relationship to Lung Cancer

Cited by 2 publications

References 1 publication

Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Procalcitonin Level in Non-Small Cell Lung Cancer Patients among Indonesian Population

Correlation between Genetic Polymorphism of CYP2A13 Genotype and Lung Cancer in Female Passive Smokers

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