The cysts in C cell complexes of dog thyroids studied by immunoperoxidase staining and autoradiography.

Kameda, Yoko

doi:10.1679/aohc.45.437

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…18). As described in a previous study (Kameda, 1982), C-cell complexes frequently showed cysts of various shapes, sizes, and lumenal contents. Fifty-two out of 73 complexes in 112 thyroid lobes contained the cysts (in the lobes with two or more C-cell complexes, only the largest complexes were estimated); the frequency of occurrence was 71.2%.…”

Section: 3)supporting

confidence: 78%

“…In contrast to the colloid of thyroid follicles, the amorphous materials in cyst lumens fixed in Bouin's solution were densely stained by the slightly diluted 19Sthyroglobulin antiserum. A previous autoradiographic study (Kameda, 1982) indicated that in dog Ccell complexes, colloid-like materials in the cyst lumens were intensely immunoreactive to the slightly diluted 19s-thyroglobulin antiserum but accumulated little radioiodine. It appears that the cysts in thyroid parenchyma, parathyroid IV, and thymus IV as well as those in C-cell complexes secrete thyroglobulin-like materials but are not involved in the synthesis of thyroid hormones.…”

Section: Discussionmentioning

confidence: 90%

“…Some cysts were continuous with groups of typical thyroid follicles. There were few C cells within the cyst walls of thyroid parenchyma, although large Ccell groups were often distributed in cyst epithelia of Ccell complexes and in those connecting thymus N and parathyroid N (Kameda, 1971(Kameda, , 1982. In chicken ultimobranchial glands, C cells have a n intimate relation with cysts: many C cells are distributed in cyst epithelia (Kameda, 1984a), and furthermore some of them directly border on the cyst lumen (Ito et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

“…Some cysts in the C-cell complexes reveal immunoreactivity for 19s-thyroglobulin and appear to have secretory activity (Kameda, 1982). In the course of study of dog thyroid glands, I have noticed that cysts are frequently present not only in C-cell complexes but also in thyroid parenchyma itself, in parathyroid gland 111, in parathyroid gland IV, and in thymus IV located adjacent to parathyroid IV.…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Kameda

1987

Am. J. Anat.

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Cyst structures were often detected in and around thyroid glands of the dog. The present study revealed the frequency of occurrence, the light microscopic features, and the immunoperoxidase reactions to anti-keratin and anti-19S-thyroglobulin antisera of each cyst located in parathyroid III, parathyroid IV, thymus IV, C-cell complexes, and thyroid parenchyma from 112 dogs. In each location, cysts showed characteristic features. In parathyroid III, the cysts were covered with single or pseudostratified epithelium composed of ciliated cells; whereas in parathyroid IV they were covered with keratinizing stratified squamous epithelium. In C-cell complexes, small cysts lined with small packed cells were predominant, and large cysts lined with single cuboidal cells or stratified squamous cells were also present. In thymus IV located in the close vicinity of parathyroid IV, cyst epithelium consisted of several types of cells showing variable features. In thyroid parenchyma, there were several types of cysts: some were covered with ciliated columnar cells, and others were covered with two or multilayers of small packed cells or cuboidal cells. In spite of these differences in appearance of the cysts located in different tissues, all their epithelia were immunoreactive to the keratin antisera, except for small cysts in C-cell complexes, which were regarded as immature structures. Thus, the presence of keratin filaments in epithelial cells seems to be a characteristic feature of all cysts. The lumens of each cyst contained variable amounts of amorphous materials, which showed colloid-like, flocculent, foamy, and granular features and were periodic acid-Schiff-positive in variable degrees, from weak to intense. Although the lumenal contents of the cysts in parathyroid III revealed no immunoreactivity for 19S-thyroglobulin, those in thyroid parenchyma, C-cell complexes, parathyroid IV, and thymus IV reacted strongly with the 19S-thyroglobulin antiserum.

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Section: 3)supporting

confidence: 78%

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Kameda

1987

Am. J. Anat.

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“…These structures are closely related to certain cells of UBB vestiges which may be not of neuroectodermal origin but of endodermal origin (Ozaki et al, 1991). In mammalian species, including the buffalo (present study), the C-cells were partially or completely disseminated among the follicles of the thyroid gland; but they occasionally formed fairly large cellular clusters around or near the parathyroid IV (Kameda, 1977(Kameda, , 1982(Kameda, , 1995Kameda and Ikeda, 1980), which were regarded as the remnant of the embryonic UBB (present study). Parafollicular cells occasionally formed narrow to large colloid-containing follicles.…”

Section: The C-cell Complexes Are Normal Components Of Thyroid Gland Of Mammalssupporting

confidence: 51%

Immunomorphological Study of Ultimobranchial Body Remnants in the Thyroid Gland of Buffalo (Bos Bubalis)

2009

Assiut Veterinary Medical Journal

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Development of immunoreactive somatostatin in C-cell complexes in the thyroid gland of the dog

Kameda

1984

Cell Tissue Res.

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In connection with our previous finding that an intense immunoreaction to somatostatin transiently appears in thyroid C cells of the dog during early fetal periods, the present study investigated C-cell complexes in thyroid glands from early fetuses to adults in an attempt to clarify whether the transient appearance of immunoreactivity to somatostatin is dependent on the degree of differentiation of C cells. C-cell complexes retain their fetal characteristics; even in the complexes of postnatal dogs, there are numerous undifferentiated cells, immature C cells and primitive follicular cells, which are not yet organized into follicles. Neither the degree of differentiation of C cells nor that of other constituent elements of the complexes affected the developmental pattern of somatostatin immunoreactivity in C cells. The C cells located in complexes displayed the same pattern of developmental changes in immunoreactivity to somatostatin as the cells in thyroid parenchyma. In the C-cell complexes of early fetal dogs a very intense immunoreactivity for somatostatin was observed; almost all calcitonin-positive cells were also somatostatin positive. The immunoreactivity to somatostatin progressively decreased with age. In the postnatal complexes the number of somatostatin-positive cells was very small compared with that of calcitonin-positive cells.

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The cysts in C cell complexes of dog thyroids studied by immunoperoxidase staining and autoradiography.

Cited by 6 publications

References 17 publications

Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Immunohistochemical demonstration of keratins in the cysts of thyroid glands, parathyroid glands, and C‐cell complexes of the dog

Immunomorphological Study of Ultimobranchial Body Remnants in the Thyroid Gland of Buffalo (Bos Bubalis)

Development of immunoreactive somatostatin in C-cell complexes in the thyroid gland of the dog

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