The cytoplasmic tail of the D1A receptor subtype: identification of specific domains controlling dopamine cellular responsiveness

Chaar, Ziad Y.; Jackson, Adele; Tiberi, Mario

doi:10.1046/j.1471-4159.2002.01003.x

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, one can envision mutating Ser199 5.43 of hD 1 R may restrict the movements of TM5 during the spontaneous isomerization to the R * state and thus impede agonist-independent G protein coupling. In other words, the hD 1 R may possess a CT that offers more steric hindrance to the docking of G s compared to that of hD 5 R, which may account for its lower constitutive activity compared to hD 5 R. In support of this, when we truncated the CT of hD 1 R, we observed an elevation in its agonistindependent activity (Chaar, Jackson, & Tiberi, 2001). Other important residues regulating hD 1 R constitutive activity are shown.…”

Section: Molecular Basis For the Constitutive Activities Of D 1 -Classupporting

confidence: 54%

Constitutive Activities and Inverse Agonism in Dopamine Receptors

Zhang

Albaker

Plouffe

et al. 2014

Advances in Pharmacology

Self Cite

View full text Add to dashboard Cite

Section: Molecular Basis For the Constitutive Activities Of D 1 -Classupporting

confidence: 54%

Constitutive Activities and Inverse Agonism in Dopamine Receptors

Zhang

Albaker

Plouffe

et al. 2014

Advances in Pharmacology

Self Cite

View full text Add to dashboard Cite

“…Other studies also indicated that the cytoplasmic tail of D1-like receptors, especially the N-terminal segment termed as the fourth intracellular loop, played a crucial role in the regulation of the activation of adenylyl cyclase, ligand binding, expression, and G protein coupling properties [ 48 - 52 ]. Members of G protein coupled receptors displayed considerable amino acid sequence conservation within transmembrane domains [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

The genetic effects of the dopamine D1 receptor gene on chicken egg production and broodiness traits

Shen

Zhou

et al. 2010

BMC Genet

View full text Add to dashboard Cite

BackgroundThe elevation of egg production and the inhibition of incubation behavior are the aims of modern poultry production. Prolactin (PRL) gene is confirmed to be critical for the onset and maintenance of these reproductive behaviors in birds. Through PRL, dopamine D1 receptor (DRD1) was also involved in the regulation of chicken reproductive behavior. However, the genetic effects of this gene on chicken egg production and broodiness have not been studied extensively. The objective of this research was to evaluate the genetic effects of the DRD1 gene on chicken egg production and broodiness traits.ResultsIn this study, the chicken DRD1 gene was screened for the polymorphisms by cloning and sequencing and 29 variations were identified in 3,342 bp length of this gene. Seven single nucleotide polymorphism (SNPs) among these variations, including a non-synonymous mutation (A+505G, Ser169Gly), were located in the coding region and were chosen to analyze their association with chicken egg production and broodiness traits in 644 Ningdu Sanhuang individuals. Two SNPs, G+123A and C+1107T, were significantly associated with chicken broody frequency (P < 0.05). Significant association was also found between the G+1065A - C+1107T haplotypes and chicken broody frequency (P < 0.05). In addition, the haplotypes of G+123A and T+198C were significantly associated with weight of first egg (EW) (P = 0.03). On the other hand, the distribution of the DRD1 mRNA was observed and the expression difference was compared between broodiness and non-broodiness chickens. The DRD1 mRNA was predominantly expressed in subcutaneous fat and abdominal fat of non-broodiness chicken, and then in heart, kidney, oviduct, glandular stomach, hypothalamus, and pituitary. In subcutaneous fat and abdominal fat, the level of non-broodiness was 26 to 28 times higher than that of broodiness. In pituitary, it was 5-fold higher. In heart, oviduct, and kidney, a 2-3 times decrease from non-broodiness to broodiness was displayed. In glandular stomach and hypothalamus, the level seen in non-broodiness and broodiness was almost the same.ConclusionThe polymorphisms of the DRD1 gene and their haplotypes were associated with chicken broody frequency and some egg production traits. The mRNA distribution was significant different between broodiness and non-broodiness chickens.

show abstract

The cytoplasmic tail of the D1A receptor subtype: identification of specific domains controlling dopamine cellular responsiveness

Cited by 2 publications

References 0 publications

Constitutive Activities and Inverse Agonism in Dopamine Receptors

Constitutive Activities and Inverse Agonism in Dopamine Receptors

The genetic effects of the dopamine D1 receptor gene on chicken egg production and broodiness traits

Contact Info

Product

Resources

About