1981
DOI: 10.1016/0090-6980(81)90127-1
|View full text |Cite
|
Sign up to set email alerts
|

The cytoprotective effects of (±)-15-deoxy-16-α,β-hydroxy-16-methyl PGE1 methyl ester (SC-29333) versus aspirin-shock gastric ulcerogenesis in the dog

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
4
0
3

Year Published

1984
1984
2004
2004

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 45 publications
(8 citation statements)
references
References 7 publications
1
4
0
3
Order By: Relevance
“…One possibility is through the antioxidant activity of this substance and its ability to scavenge hydrogen peroxide and other hydroperoxides ( 10, 1 1). Our findings are also consistent with the observations of other investigators, in which shock has been noted to enhance the damaging effects of acid (20,21), aspirin (22), taurocholate (21, 23), and ethanol (24), when topically applied to the gastric mucosa, and to prevent the protective action of a prostaglandin against aspirin damage (22). Our findings also confirm the earlier observations of Lu and associates ( 5 ) by showing that intraperitoneal NAC does not possess protective activity against alcohol injury, regardless of the length of the pretreatment period.…”
Section: N-acetyl-cysteine and Gastric Damagesupporting
confidence: 94%
“…One possibility is through the antioxidant activity of this substance and its ability to scavenge hydrogen peroxide and other hydroperoxides ( 10, 1 1). Our findings are also consistent with the observations of other investigators, in which shock has been noted to enhance the damaging effects of acid (20,21), aspirin (22), taurocholate (21, 23), and ethanol (24), when topically applied to the gastric mucosa, and to prevent the protective action of a prostaglandin against aspirin damage (22). Our findings also confirm the earlier observations of Lu and associates ( 5 ) by showing that intraperitoneal NAC does not possess protective activity against alcohol injury, regardless of the length of the pretreatment period.…”
Section: N-acetyl-cysteine and Gastric Damagesupporting
confidence: 94%
“…In the stomach they inhibit basal gastric acid secretion and secretion stimulated by food and histamine (Steiner 1985). Prostaglandins also have a trophic action on the gastric mucosa (Helander et al 1985), and increase bicarbonate secretion (Kauffman et al 1980), mucus production, and mucosal blood flow (Larsen et al 1981;Leung et al 1985). Prostaglandin E2 has been shown to inhibit histamine-stimulated acid secretion by inhibiting adenylate cyclase via the inhibitory guanosine triphosphate (GTP) binding protein and decreasing cyclic adenosine monophosphate (cAMP) production (Chen et al 1988).…”
Section: Prostaglandin Analoguesmentioning
confidence: 99%
“…Ya desde las primeras referencias bibliográficas publicadas en 1981 como SC-29333, el producto demostró su eficacia como agente protector gástrico especialmente en casos de ulcerogénesis inducida por AAS en ensayos en animales [6]. El primer ensayo en humanos fue publicado en 1982 [7].…”
Section: Discussionunclassified