The Cytostatic Activity of the Chlorohyssopifolins, Chlorinated Sesquiterpene Lactones from Centaurea¹

Sesquiterpenoids in subtribe Centaureinae (Cass.) Dumort (tribe Cardueae, Asteraceae): Distribution, 13C NMR spectral data and biological properties

“…Dihydroestafiatone (270), on the other hand, showed poor cytostatic action (Gonzalez et al, 1978a). Compounds 224,217,212,228,227,162, and 149 were also tested for cytostatic action on HeLa cells: the first four exhibited an ID 50 in the range 0.25-0.5 lg/mL (Gonzalez et al, 1980b). Furthermore, grosshemin (264) inhibited the growth of malignant HeLa cultures.…”

“…Nowak (1992), Nowak et al (1996) Psephellus somcheticus Nowak et al (1986bNowak et al ( , 1996, Nowak (1992) Psephellus taochius Nowak et al (1986b) Psephellus zangezuri Nowak et al (1986bNowak et al ( ,a, 1996 Gonzalez et al (1977aGonzalez et al ( , 1978cGonzalez et al ( ,a, 1980b) Centaurea canariensis ssp. subexpin.…”

“…subexpin. Gonzalez et al (1977aGonzalez et al ( , 1978cGonzalez et al ( ,a, 1980b Gonzalez et al (1977aGonzalez et al ( , 1978c) Centaurea canariensis ssp. subexpin.…”

“…Also compound 32 exhibited moderate antibacterial activity only toward Gram+ bacteria (Suleimenov et al, 2005b Barrero et al, 1997b. Gonzalez et al (1977aGonzalez et al ( , 1978cGonzalez et al ( ,a, 1980b) Centaurea canariensis ssp. subexpin.…”

Salograviolide A: A Plant-Derived Sesquiterpene Lactone with Promising Anti-Inflammatory and Anticancer Effects

“…When entering on PubMed the search terms "Centaurea and sesquiterpene lactones", and adding to them the hits from the search "Centaurea and cancer", 46 results get displayed. We investigated the number, nature and biological activity of SLs in the different species and summarized some of them in Table 1 (Bruno et al, 2005;Chicca et al, 2011;Csupor-Löffler et al, 2009;El-Najjar et al, 2007;Ghantous et al, 2007;González et al, 1980;Koukoulista et al, 2002;Saroglou et al, 2005). Nowak et al, 1993-3: Cho et al, 2004-4: Medjroubi et al, 2005-5: Bach et al, 2011-6: Vajs et al, 1999-7: Djeddi et al, 2007, 2008-8: González et al, 1980-9: Ozçelik et al, 2009-10: Youssef et al, 1994, 1998-11: Akkol et al, 2011-12: Cheng et al, 1992-13: Gürbüz et al, 2007-14: Ozçelik et al, 2009-15: Saroglou et al, 2005-16: Lakhal et al, 2010-17: Fortuna et al, 2001-18: Lonergan et al, 1992 (Fig.…”