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1,3-Dipolar cycloaddition of benzyl azide or peracetylated glucopyranosyl azides to propargyl halides or 1,4-dihalobutynes yielded 1-benzyl- or 1-glycosyl(halomethyl)-1,2,3-triazoles. Alkylating chloromethyl- bromomethyl- and iodomethyl-1,2,3-triazoles were also obtained from the corresponding hydroxymethyl derivatives by treatment with (C6H5)3P/CCl4, (C6H5O)3P/Br2, and (C6H5O)3P/I2, respectively. 1-Benzyl-4-(fluoromethyl)-1,2,3-triazole was obtained from 1-benzyl-4-(bromomethyl)-1,2,3-triazole by treatment with KF and 18-crown-6. Chloromethyl-, bromomethyl-, and iodomethyl-1,2,3-triazole derivatives inhibited the "in vitro" growth of HeLa cells. Some of these compounds increased the life span of mice bearing tumors.

isolated from members of the Compositae of the Canary Islands. Nine of these The c~tostatic properties of a series of compounds were isolated for the first fifteen lactones from some Compositae in the Institute de Productos Nacollected in the Canary Islands were turales Orginicos, Tenerifem examined. Nine of these lactones were isolated for the first time in the Instituto de Productos Naturales Orginicos of Material and Methods Tenerife. It would seem that an a-methylene-y-lactone grouping in the mole-The products under study are all sesquitcrpene lactones. Figure 1 shows their chemical is for c~totOxic structure and are listed with the plant species from which they were prepared:

The synthesis of a series of N‐glycosyl‐v‐triazoles has been accomplished by the 1,3‐dipolar cycloaddition of several glycosyl azides to methyl propiolate and propiolic acid. In most of the cases the two isomeric v‐triazoles were obtained. Structural and anomeric configuration assignments for the N‐glycosides obtained were made on the basis of NMR data. None of the compounds possessed appreciable biological activity against HeLa cells in culture and mouse Sarcoma 180.

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