The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation

Rabolli, Virginie; Thomassen, Leen; Uwambayinema, Francine; Martens, Johan A.; Lison, Dominique

doi:10.1016/j.toxlet.2011.07.013

Cited by 77 publications

(65 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It seems to be very important to compare the toxicity data obtained via different methods in order to explain cell response to nanoparticles exposure (Fede et al 2012). There are many studies, however, concerning the toxicity of silver and silica nanoparticles, but the precise mechanism of interaction between living cells and silica nanoparticles, and the silver-silica nanoparticles system are still not known, requiring further investigations (Kim et al 2015;Fede et al 2012;Rabolli et al 2011;Besinis et al 2014;Schneider 2017).…”

Section: Estimation Of the Antibacterial Activity Of The Fibersmentioning

confidence: 99%

Antibacterial composite cellulose fibers modified with silver nanoparticles and nanosilica

et al. 2018

View full text Add to dashboard Cite

In the present research, nanocomposite antibacterial cellulose fibers of Lyocell type modified with nanosilver particles and nanosilica were obtained. Nanosilver particles were generated by the chemical reduction of silver nitrate (AgNO 3 ) in 50% water solution of N-methylmorpholine N-oxide (NMMO), which was applied as a direct cellulose solvent for the production of Lyocell fibers. The main aim of this study has been to obtain antibacterial cellulose fibers modified with silver nanoparticles, which are entirely safe for contact with human tissue. Taking into account the potential medical applications of the obtained fibers, the antibacterial activity and cytotoxicity of silver nanoparticles enclosed in fibers were examined in human and mouse cells. Considering the size of the silver nanoparticles with nanosilica in NMMO and their physical properties, the time of generation was the subject of a thorough analysis. The basic physical properties of the nanoparticles introduced in the fibers were tested using the UV/VIS, DLS and TEM methods. The basic properties of the fibers, namely the mechanical and hydrophilic ones, and the average degree of polymerisation of the cellulose fibers were estimated. The conditions of the synthesis of nanoparticles in NMMO with nanosilica were optimised. The results have confirmed that fibers with high-quality antibacterial properties, safe for human tissue and suitable for medical purposes, could be obtained.

show abstract

Section: Estimation Of the Antibacterial Activity Of The Fibersmentioning

confidence: 99%

Antibacterial composite cellulose fibers modified with silver nanoparticles and nanosilica

et al. 2018

View full text Add to dashboard Cite

show abstract

“…However, it has also been stressed to consider each nanomaterial on a case-by-case basis due to the heterogeneity in their properties, which can influence their biological activity. These properties include surface chemistry, polarity, porosity, particle size and morphology, solubility and chemical purity (Fruijtier-P€ olloth, 2012;Rabolli et al, 2010Rabolli et al, , 2011. Therefore, systematic studies with well characterized nanomaterials and defined protocols are necessary to obtain an understanding of the influence of physico-chemical and biological factors on their toxicity.…”

Section: Original Articlementioning

confidence: 99%

Differential cytotoxic and inflammatory potency of amorphous silicon dioxide nanoparticles of similar size in multiple cell lines

et al. 2017

View full text Add to dashboard Cite

The likelihood of environmental and health impacts of silicon dioxide nanoparticles (SiNPs) has risen, due to their increased use in products and applications. The biological potency of a set of similarly-sized amorphous SiNPs was investigated in a variety of cells to examine the influence of physico-chemical and biological factors on their toxicity. Cellular LDH and ATP, BrdU incorporation, resazurin reduction and cytokine release were measured in human epithelial A549, human THP-1 and mouse J774A.1 macrophage cells exposed for 24 h to suspensions of 5-15, 10-20 and 12 nm SiNPs and reference particles. The SiNPs were characterized in dry state and in suspension to determine their physico-chemical properties. The doseresponse data were simplified into particle potency estimates to facilitate the comparison of multiple endpoints of biological effects in cells. Mouse macrophages were the most sensitive to SiNP exposures. Cytotoxicity of the individual cell lines was correlated while the cytokine responses differed, supported by cell type-specific differences in inflammation-associated pathways. SiNP (12 nm), the most cytotoxic and inflammogenic nanoparticle had the highest surface acidity, dry-state agglomerate size, the lowest trace metal and organics content, the smallest surface area and agglomerate size in suspension. Particle surface acidity appeared to be the most significant determinant of the overall biological activity of this set of nanoparticles. Combined with the nanoparticle characterization, integration of the biological potency estimates enabled a comprehensive determination of the cellular reactivity of the SiNPs. The approach shows promise as a useful tool for first-tier screening of SiNP toxicity. ARTICLE HISTORY

show abstract

“…Drescher et al [63], using a eukaryotic cell model, saw a decrease of toxicity of amorphous SiO 2 nanoparticles in case of agglomeration. However, in these experiments the addition of serum may be a confounding factor [64]. Another study regarding the cytoxicity of monodisperse amorphous SiO 2 nanoparticles and assemblages thereof found no effect of aggregation and suggested as cause that the availability of nanoparticle surface area remained unaffected by the formation of assemblages [64].…”

Section: Determinants Of Human Inhalation Hazards Of Persistent Enginmentioning

confidence: 95%

“…However, in these experiments the addition of serum may be a confounding factor [64]. Another study regarding the cytoxicity of monodisperse amorphous SiO 2 nanoparticles and assemblages thereof found no effect of aggregation and suggested as cause that the availability of nanoparticle surface area remained unaffected by the formation of assemblages [64]. Agglomerates of persistent nanoparticles with other substances may strongly impact hazard [29,[64][65][66].…”

Section: Determinants Of Human Inhalation Hazards Of Persistent Enginmentioning

confidence: 99%

“…Another study regarding the cytoxicity of monodisperse amorphous SiO 2 nanoparticles and assemblages thereof found no effect of aggregation and suggested as cause that the availability of nanoparticle surface area remained unaffected by the formation of assemblages [64]. Agglomerates of persistent nanoparticles with other substances may strongly impact hazard [29,[64][65][66]. For instance, agglomeration of carbon black nanoparticles with a variety of proteins may be highly conducive to the translocation of carbon black nanoparticles from the lungs to the bloodstream and to deposition in other organs [66].…”

Section: Determinants Of Human Inhalation Hazards Of Persistent Enginmentioning

confidence: 99%

See 1 more Smart Citation

Human health hazards of persistent inorganic and carbon nanoparticles

Reijnders

2012

J Mater Sci

View full text Add to dashboard Cite

Persistent inorganic and carbon nanoparticles are increasingly engineered for applications and may also be present in conventional materials such as carbon black. Furthermore, they may originate from conventional non particulate materials by processes such as wear and tear. Persistent inorganic and carbon nanoparticles can be hazardous to humans. Relatively much research regards the hazards of inhaled nanoparticles. These may give rise to respiratory disease and to negative effects on other organs, including the cardiovascular system. Determinants of risk of inhaled nanoparticles include: number, size, surface characteristics, shape, structure, and the formation of assemblages. These determinants should preferentially be considered in exposure metrics. A major molecular mechanism underlying the inhalation hazard of nanoparticles is the generation of reactive oxygen species, but other mechanisms such as interactions with proteins and DNA may also contribute. Health hazards may also be linked to ingestion of persistent inorganic and carbon nanoparticles, dermal exposure and exposure of the eye. Standards for workplace exposure to persistent inorganic and carbon are currently emerging and there are options for hazard reduction by elimination and substitution of hazardous nanoparticles and by engineering controls.

show abstract

The cytotoxic activity of amorphous silica nanoparticles is mainly influenced by surface area and not by aggregation

Cited by 77 publications

References 26 publications

Antibacterial composite cellulose fibers modified with silver nanoparticles and nanosilica

Antibacterial composite cellulose fibers modified with silver nanoparticles and nanosilica

Differential cytotoxic and inflammatory potency of amorphous silicon dioxide nanoparticles of similar size in multiple cell lines

Human health hazards of persistent inorganic and carbon nanoparticles

Contact Info

Product

Resources

About