The cytotoxic and genotoxic potential of surface water and wastewater effluents as determined by bioluminescence, umu-assays and selected biomarkers

Dizer, H.; Wittekindt, E.; Fischer, Birgit; Hansen, Peter-Diedrich

doi:10.1016/s0045-6535(01)00062-5

Cited by 100 publications

(52 citation statements)

References 17 publications

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“…Aguayo et al (2004) found that the effluent from 7 investigated STPs all showed toxic effects to Daphnia magna, while some samples showed estrogenicity and teratogenicity. Dizer et al (2002) reported that samples taken from a river accepting the secondary effluent caused genotoxic responses in the umu assay. The secondary effluent was also reported to induce significant reduction of hatching rates and increase of embryo lesions of exposed Japanese medaka (Oryzias latipes) embryo (Zha and Wang, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of wastewater reclamation technologies based on in vitro and in vivo bioassays

Cao

Yang

Zhang

et al. 2009

Science of The Total Environment

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Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Evaluation of wastewater reclamation technologies based on in vitro and in vivo bioassays

Cao

Yang

Zhang

et al. 2009

Science of The Total Environment

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“…Because of the complexity and cost of such an endeavor, there is strong interest in simplifying toxicity assessment. A common alternative is to use microorganisms genetically engineered to be sensitive to specific contaminants, resulting in assays that are more rapid and less costly (Wood and Gruber, 1996;Hollis et al, 2000;Dizer et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Chemical speciation and toxicity of metals assessed by three bioluminescence‐based assays using marine organisms

Deheyn

Bencheikh-Latmani

Latz

2004

Environmental Toxicology

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ABSTRACT:Metal toxicity is a function of the biology of the target organism and the chemical speciation of the metal. The toxicity of 11 metals was assessed with three cell-based bioassays based on marine organisms: the bacterium Photobacterium phosphoreum of the Microtoxா bioassay, an environmental strain of P. phosphoreum, and photocytes isolated from the brittlestar Ophiopsila californica. Metal speciation was calculated for three commonly used media: NaCl-based Microtoxா bioassay medium, artificial seawater glycerol, and artificial seawater. Decreased bioluminescence was considered a proxy for cell toxicity. In all three assays the elements Cd and Hg exhibited similar speciation as well as similar toxicity profiles. The element Cu was toxic in all three assays despite different metal speciation for the P. phosphoreum bioassay. The element Ag was toxic to both bacterial strains but not to photocytes despite a similar chemical speciation for all three assays. In general, the Microtoxா bioassay was sensitive to all metals (except Pb), whereas the photocytes were the least sensitive to the metals. The heightened response of the Microtoxா bioassay probably resulted from a combination of the limited complexing power of the medium and the greater sensitivity of the bacterial strain.

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“…In order to provide a first toxicological investigation and status assessment of the River Danube, two widely used, easily applicable toxicological tests were applied for all JDS3 samples (umuC and MTS). These tests have been used for the investigation of surface waters by other groups [2][3][4][5][6] and have been additionally established and used for the investigation of the River Mur in Styria, Austria [7]. The investigation of the water samples with these protocols is very reliable in terms of unspecific screening for toxic signals in surface or waste water samples [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Toxicological Evaluation of the River Danube Using in Vitro Bioassays

Kittinger

Baumert

Folli

et al. 2015

Water

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Abstract:The Joint Danube Survey 3, carried out in 2013 was the world's biggest river research expedition of its kind. The course of the second largest river of Europe passes large cities like Vienna, Budapest and Belgrade and is fed from many tributaries like Inn, Thisza, Drava, Prut, Siret and Argeș. During the 6 weeks of shipping the 2375 km downstream the River Danube from Germany to the Black Sea an enormous number of water samples were analyzed and collected. A wide spectrum of scientific disciplines cooperated in analyzing the River Danube waters. For toxicological analysis, water samples were collected on the left, in the middle, and on the right side of the river at 68 JDS3 sampling points and frozen until the end of the Danube survey. All samples were analyzed with two in vitro bioassays tests (umuC and MTS). water samples came up with toxic signals on two stretches, when activated with S9 enzymes. The override of the limiting value of the umuC investigation with prior S9 activation started downstream Vienna (Austria) and was prolonged until Dunaföldvar (Hungary). This stretch of the River Danube passes a region that is highly industrialized, intensively used for agricultural purposes and also highly populated (Vienna, Bratislava and Budapest). The elevated values may indicate these influences.

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The cytotoxic and genotoxic potential of surface water and wastewater effluents as determined by bioluminescence, umu-assays and selected biomarkers

Cited by 100 publications

References 17 publications

Evaluation of wastewater reclamation technologies based on in vitro and in vivo bioassays

Evaluation of wastewater reclamation technologies based on in vitro and in vivo bioassays

Chemical speciation and toxicity of metals assessed by three bioluminescence‐based assays using marine organisms

Preliminary Toxicological Evaluation of the River Danube Using in Vitro Bioassays

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